Well I know I've been eating way too much as Enbrel increases my appetite, I don't know weather it changes my metabolism or not, but also going through menopause right now doesn't help. Anyway, the Dr. gave me metafomin to try, though I'm not diabetic. I have been afraid to take it so far. If I don't take it I might try the weight loss drug Ali. I know it depleats some vitamins, but I'm getting on some great multivitamin/multi-minerals from youngevity soon. I haven't been taking my Enbrel shot but every two weeks and still no pain and skin clearing.