Ingesting Glycerin

Hi Everyone, I'm very new to this forum. I posted once before asking about drinking ionized (alkaline) water but had few replies so I assume that might be a dead topic. However I did stumble across a thread about drinking apple cider vinegar for balancing ph levels so maybe there is something to it? I'm really thinking about buying a machine (not Kangen brand) and would love to here your thoughts...anyway back to the topic. I remember reading in one of the threads but cannot find it now, where we are to not only apply the glycerin topically but are drinking it as well? Can somebody give me a brief routine of quantity and frequency to do this? I'm heading to Whole Foods today to pick some up! Oh yeah, and what kind should I get? I really enjoy reading all of your posts and am so greatful to all of you and this wonderful forum!

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There appears to be a lot of confusion regarding the oral dosing of glycerin.
It should only be taken orally when under the care of a doctor.
Self medicating by orally dosing oneself with glycerin can be dangerous.
It is not about whether it is USP 99.5% pure or 100% pure glycerin it is about how glycerin interacts with our bodily functions.

Following info from>>>

Glycerin (Oral Route)
Drug Information provided by: Micromedex

US Brand Names

Canadian Brand Names


Glycerin , when taken by mouth, is used to treat certain conditions in which there is increased eye pressure, such as glaucoma. It may also be used before eye surgery to reduce pressure in the eye.

Glycerin may also be used for other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, glycerin is used in certain patients with the following medical conditions:
Cerebral edema (swelling of the brain)

This product is available in the following dosage forms:
At the very least, anyone thinking about drinking glycerin would do well to give their doctor a call and get their professional opinion. Good Luck

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Thank-you for the Mayo Clinic website info on glycerin! Very informative and helpful!

I always think that no matter what medicine, supplement or treatment that a person / patient with psoriasis takes, it is always best to make sure that your doctor knows what you're doing.

It's always a good idea to make your doctor aware of any major diet changes as well - if you're consuming any products out there that might have chemicals or other ingredients that might effect your current course of treatment.

There are some herbal and homeopathy substances which can have significant reactions with some drugs prescribed for psoriasis and psoriatic arthritis. St. John's Wart and others can impact a number of other Immunosupressant medications. Even something as simple as grapefruit juice can be dangerous with certain psoriasis medications.

It's also very important to include ALL of your medications and therapies that you take for other conditions besides psoriasis or psoriatic arthritis. If you take medications for arthritis, asthma, diabetes, depression, fibromyalgia, etc. etc, your SKIN doctor - whether general practice, primary care, or dermatology - needs to know ALL the pills, supplements, injections, etc that are going into your body.

Unfortunately, in this 'worldwide' environment of Inspire, many people don't have access to dermatologists, much less medications. For those persons who don't have medical access - whether from lack of insurance, physical location, etc, - just by virtue of being online, you'll hopefully have access to a wealth of information online -- both good and bad! The difficult part is sifting through the huge volumes of material available and trying to determine the very best treatments based on your personal access, financial capacity, and physical location.

There was a recent posting on another thread that mentioned how dangerous it can be to self-diagnose based solely on information found online. A study that got a lot of press in recent weeks highlighted the problems associated with that same concept. Getting a medical opinion (or two or three in serious cases) is always a good idea.

If you have access, and can afford to see a doctor or specialist, be sure to tell them before you start any new treatment - or if you're making any changes to your current routine or diet that might affect your treatment.

If a doctor's out of the question for you, then try to do as much research as you possibly can to learn all about any form of treatment that you are considering. There's a lot of great information available online (like the MayoClinic site mentioned above!) and also a lot of misinformation out there as well.

consumer beware -- always, especially when you're a patient-consumer!

peace and healing,

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Ingesting small amounts of glycerin appears to be harmless but I agree researching the matter can only be prudent, especially if it is something you are looking to do for an indefinite period. This should be true of any sort of supplement.


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With all due respect to the concerns of others, I will continue ingesting glycerin because it eases my psoriatic arthritis pain.

Because the pain is diminished, today I will push mow a lawn that is slanted, making it more challenging. The lot size is 7/8 of an acre, so a lot to mow, even when the area is reduced by the footprint of the house, driveway, and a small wooded portion. I probably won't trim today, but that will be because I have an appointment, not because my joints couldn't take it.

That level of physical exertion was impossible for the last five years. (I am 62 years old)

At the root of this post is how my view of medicine differs from some other Posters.

While not medically trained, I have exponentially MORE experience with my body than any other person on the planet.

I view doctors as highly respected professionals who have a variety of strong influences on how they provide service.

Pharmaceutical companies have a life-and-death (financially) motivation to influence which drugs are prescribed by doctors.
Plus their desire to have doctors prescribe drugs with high profit margins. How CAN someone charge $1,600 for four 50 mg sureclick autoinjectors filled with Enbrel? Note that I am having more pain relief from drinking glycerin that was provided by injecting for three and a half years.
I am suggesting patients be cognizant of the forces of our free market model.

Lawyers, in combination with health insurance providers (include medicare / medicaid) force doctors to prescribe remedies that are legally supportable, in case a poor outcome leads to a lawsuit. Should glycerin cause me a health problem, I cannot sue anyone. However, if Enbrel had resulted in tuberculosis, and I sued, counter arguments in court would probably include that I was informed the condition occurred in a "small number of patients". Plus, while using Enbrel, I was regularly tested for TB so that it would hopefully be caught in time for successful treatment. Hmmm, THERE is part of the reason four little plastic tubes cost $1,600!
I.E., my Enbrel treatment was expensive for legal reasons more so than medical reasons.

Should a doctor choose recommending non-traditional treatment despite those forces, in most cases a hospital administrator will "encourage" him/her to fall back in line.

All of that pressure applied to someone who primarily wants to heal.

It is amazing so many persevere to join the medical profession.

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I just ordered some vitamins and supplements and found it interesting that they use Glycerin as a filler! And yes I did buy veggie grade Glycerin. Have not tried it yet, but on antibiotics and want to wait till I am felling better so I will know exactly how it is working.

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Good advice quest4cure, when it comes to self medicating it is always user beware.
Even under a doctors care medicines, herbs, supplements can have dire effects.
From what I understand, glycerin is a rather potent diuretic thus the cause for concern regarding liver, and kidney functions, and also serious implications regarding eyes and even brain function. I can only extrapolate and assume that glycerin will also effectively remove moisture from our joints and other organs. Basically when taken orally it will dry us out, by drawing fluids out of our system through our digestive tract.
It also doesn't seem matter the source, all glycerol is alike be it sourced from animal, mineral or vegetable.
It might make us feel better to think that we are not using a petroleum by-product, but it is all the same stuff in the end.
Interesting that despite the warnings, and health risks when used as an oral dose drug, the warnings are virtually non-existent when I read about E422 food additive (glycerol). I also couldn't pin down any limitations on how much is allowed in food as an additive. Some interesting tidbits are that glycerol is an effective anti-freeze for internal combustion engines, and can be used as an industrial equipment lubricant. I suppose some form of logic would dictate that if it is good for automobiles and other heavy equipment, it must also be good for the human machine :-O
I am considering a turtle wax cure. Everyone likes turtles!

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SORRY that your question wasn't answered prior to getting into considerable reading!

There are very few people ingesting glycerin and a number recommending not to.

I weigh 235 pounds. Twice a day I drink an ounce of glycerin mixed with warm water, two teaspoons of honey and two teaspoons of apple cider vinegar. For the purpose of arthritis pain relief, the honey and apple cider vinegar are optional. They are both purported to help a number of conditions, but I drank them without the glycerin for a long time before adding glycerin and did not experience pain relief.

Advised of my weight because the amount of glycerin needed should vary with weight.
My first diagnosis of arthritis was for ankles about eleven years ago. Knees were never diagnosed, but began feeling like ankles about a year ago. The amount of glycerin was varied to find the minimum amount that keeps knees at 100 percent and ankles much better, and possibly continuing improvement.

This is a non-traditional approach to the problem and you do so at your own risk.

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Hawkeye249, 2 ounces (or 4 tablespoons) per day doesn't sound like you are chugging the stuff. And the cost, less than $1 per day, is darn good for PsA relief!!


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Many supplement stores are familiar with glycerin only as a sweetener, often for diabetics who use it instead of sugary products, as it does not impact blood sugar or insulin. It is FDA-rated as "GRAS", generally regarded as safe, and is added and used in a huge range of commercial food products. It is also used by some athletes to improve endurance and combat</b> dehydration.

Here's a quote from a doctor studying glycerin:

Atkins Nutritionals says that glycerine is another carbohydrate that has “a minimal impact on blood sugar.” Dr. Thomas Wolever, professor and acting chair of the department of nutritional sciences at the University of Toronto, confirms this in personal correspondence... . He also heads a company, Glycaemic Index Testing Inc., which has ascertained the GI value of hundreds of foods.

“We did a study on glycerine at GI Testing, but the data don’t belong to me so I cannot publish it — except it was published in abstract form — and up to 75g [~2 oz] glycerine had a negligible effect on blood glucose and insulin in normal subjects.’ He cites his article, “Oral glycerine has a negligible effect on plasma glucose and insulin in normal subjects” in Diabetes 2002;51(Supplement 2):A602.

Here is one member's correspondence from a doctor involved in glycerin rehydration issues:

Rob Robergs
I have read the postings on the glycerol issue with interest, and need to inform you of several facts.
I am one of the University of New Mexico scientists who first researched glycerol hyper hydration for improved exercise performance. Based on our and Bud Riedesel's findings (1987), the university invested in patent protection for using glycerol as a hyper hydration agent suitable for use during exercise. In 1996, the patent was purchased by InterNutria, a nutritional supplements company within the larger InterNueron Pharmaceutical Company. Thus, InterNutria has patent protection for using glycerol hyper hydration for enhancing exercise performance.

I am currently contracted by InterNutria to provide scientific advice and commentary on their glycerol product - "ProHydrator". ProHydrator was scheduled to be released to market this June, but the USOC ban on glycerol 'came out of the blue' and has delayed the product release. Such a delay was decided by the company due to the sponsorship of USA Triathlon, as well as several professional triathletes.

From my understanding, the USOC ban is based on glycerol being classified as a tissue dehydrator. Other tissue dehydrators are mannitol, sorbitol, and urea. Such substances are routinely used in clinical practice to dehydrate the brain and eye as a treatment for edemas resulting from a variety of clinical disorders. It just so happens that mannitol, sorbitol, and urea are also potent osmotic diuretics. Glycerol seems to have been included in the banned list of mannitol and sorbitol due to the potential for glycerol-induced diuresis.

I have recently written a major review of the clinical and applied uses of glycerol ingestion. It is currently in review. Within this manuscript is a section that pertains to glycerol-induced diuresis. It is important to remember that glycerol ingestion is not the same as glycerol hyper hydration. The latter involves the additional ingestion of 1-2 L of water. Simply ingesting a concentrated solution of glycerol will not hyper hydrate the body, but dramatically increase glycerol concentrations in the blood, interstitial fluid, and kidney filtrate. Increased urinary glycerol has the potential to increase urine flow due to retarding water reabsorption in the kidney. This is the mechanism of the diuresis from mannitol and sorbitol.

Glycerol does not cause a marked diuresis, however, because glycerol is still rapidly reabsorbed in the proximal and distal tubules. Mannitol and sorbitol are not. There is no evidence in the medical literature for a glycerol-induced diuresis. Nevertheless, anecdotal expressions of glycerol-induced diuresis occur in many manuscripts.

I have written a scientific reply to InterNutria for use in the company petitioning the USOC to remove the ban on glycerol.

It is ironic that glycerol has been used by the world's elite athletes for many years. Although it is easy to assay for urinary glycerol, and interpret data, I do not think the testing lab has or is currently performing the assay. It would be easy to detect exaggerated use of glycerol as the kidney can reabsorb almost all glycerol up to blood glycerol concentrations approximating 1.2 mmol/L. As resting blood glycerol approximates 0.05 mmol/L and may increase to 0.5 mmol/L during extreme prolonged exercise and carbohydrate depletion, the only way to cause glycerol to appear in the urine is to ingest large quantities. Thus, if the USOC wanted to, they could easily determine a urinary concentration indicating large amounts of glycerol ingestion. For your information, urinary glycerol can increase to above 20 mmol/L within 30 min after ingesting 1.2 g glycerol/kg body wt.

The USOC is not justified in the ban on glycerol for hyper hydration or proposed metabolic advantages to athletes. Hyper hydration is no worse than ingesting liquid carbohydrate or water during exercise. In addition, glycerol turnover data indicate that 60% of glycerol is converted to glucose in the liver and kidney, 30% is incorporated into glycolysis for oxidation, and the remainder is presumably involved in triacylglycerol metabolism.

It appears that the ban on glycerol is a mistake and should be reversed in the near future. Failure to reverse the ban will not only expose to elite athletes to continued high risks of heat injury, but potentially result in a series of law suits from athletes and nutritional companies against the USOC.

I hope these facts help you understand the glycerol saga !

Rob Robergs, Ph.D.
Director: The Center For Exercise and Applied Human Physiology
The University of New Mexico

There is little or no incentive to research the product for the medical and pharmaceutical profession; as a doctor suffering with erythrodermic psoriasis, and years of research experience at Harvard, commented sardonically to me in a private communication, "No 'Vitamin M'".

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You're right, Nesielheum. A person doesn't have to read very long through these threads to realize that even under a doctor's care, things can go terribly wrong with medicines, herbs or supplements. Regardless of the prescription or remedy, it's up to the individual to take charge and try and learn as much as possible about every option that they're considering.

There's such a vast wealth of treatments and remedies out there that can have significant to marginal effects on psoriasis, psoriatic arthritis, and auto-immune disease in general - and trying to glean the ones that are the most effective and safe is a difficult task.

I'm one who will keep walking up and down every path until I find something that will work again.....

peace and healing,

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Clever comment! Not.

Glycerin works as an anti-freeze because it is totally miscible with water, but has a much lower freezing point.

And it is used as a lubricant because it is safe to do so in food processing machinery, as it is non-toxic, unlike machine oils.

With over 1500 uses (and rapidly growing), glycerin may well be the most used and useful chemical known to man.

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Thanks for all the feedback. It's alot to process but I'm feeling it might be worth a shot! Any thoughts at all about ionized water?

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Rob Robergs Ph. D. was a hired spokesman for InterNutria for the sole purpose to push their product as a hyper hydrator aka "ProHydrator". It seems that he likes the stuff, too bad his scientific report was never published. :-(
Those darn peer reviews ruin everything.
I haven't been able to find much current information on InterNutria? Just a little.
It seems they are now pushing 2 primary products, a powdered drink to relieve symptoms associated with PMS (a very good thing if it works) and a product that enhances marathon runners performance and keeps body builders PUMPED UP. Hmmm sound familiar? From what I can tell the message from the company is that glycerol is out and choline is in.
What I did find out is that as a performance enhancer Glycerol fell out of favor by elite distance athletes in the mid-90's.
There is still some favor in the body building community for drawing down fluids and giving the "cut" ripped look.
In the 90's it is true that some marathoners swore by it but even more made claims of nausea, extreme fatigue, and excessive urination.
Maybe choline will be the next PS cure.
Perhaps a fellow psoriatic will pick up the torch and pitch the stuff.

There is so much interesting stuff on oral dosing glycerin but most of the amazing stories are extremely dated.
Personally I still think it might be useful if used topically, but from what I can tell it has about "0" merit when taken internally, and chances are it will do more harm than good. And thats not good for anyone especially the person that is harmed.

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This post was initiated by ranchobernardo2 asking

"I remember reading in one of the threads but cannot find it now, where we are to not only apply the glycerin topically but are drinking it as well? Can somebody give me a brief routine of quantity and frequency to do this? I'm heading to Whole Foods today to pick some up! Oh yeah, and what kind should I get?"

@nesielheum and Quest4Cure - please keep in mind the Community Guidelines:

Be nice, be supportive

Inspire works because we support and care for one another. Be nice, and be supportive. Do your best to respect differing points of view.

Inspire is a support site, not a medical advice site.

I told the Original Poster of a non-traditional treatment that IS helping me. If there is additional risk to my health, it is almost certainly not tuberculosis. While on the traditional Enbrel, I was tested for TB prior to beginning and every year thereafter. Per doctor's orders.

Wishes for Relief to All,

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Tim is being nice, and he's very supportive. He's taken the time to find the Mayo Clinic information. He didn't have to do that.

This reminds me of that Vitamin D thread that eventually was pulled.

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@Hawkeye249, thanks for reminding us about community guidelines. So many people here enjoy injecting little barbs in their wording, perhaps because they think it is cute or they are being clever. We can all learn to disagree w/o being disagreeable.


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No, Tim wasn't being supportive. The Mayo Clinic information is for prescription glycerin specifically for the treatment of glaucoma.
That is out of context to this thread.

If anyone wants ONLY medical profession information, why come here? Better to stick to mayoclinic or webmd.

BTW, webmd encourages glycerin as the primary skin lotion ingredient. d&query=glycerin&navState=32

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Sure he is. He's merely citing information as a caveat. I have no problem with glycerin. The moisturizers that I use are glycerin rich products. Drinking glycerin, is a whole different matter. Tim's just sayin' it could harm the kidneys. Seems to me that if one chooses to try this, they should get a baseline lab test, and followup lab tests to be sure they aren't causing kidney damage.
He didn't say never, ever do this.

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Intended to clarify, not debate:

Per the mayo clinic site regarding prescribed glycerin for glaucoma, possible side effects that warrant checking with the doctor include confusion, which occurs "less common", and irregular heartbeat, which occurs "rare".

Side effects that usually do not warrant checking with the doctor include headache or nausea, occurring "more common", and diarrhea, dizziness, dryness of mouth or increased thirst, occurring "less common".

The mention of kidney disease stated that use of prescribed glycerin could make an existing condition worse.
Having a baseline test for any steroid or biologic treatment makes sense. People reading this post who have used those treatments most likely have been tested already.

Because anyone considering alternative treatment should be aware, the prescription calls for a one time dose of 1 - 2 grams of prescription glycerin per kilogram of body weight. That is to be followed by 500 milligrams of prescription glycerin per kilogram of body weight EVERY SIX HOURS.

For my 235 pounds, that calculates to a one time dose of 3.8 to 7.6 ounces followed by 1.88 ounces every six hours.

If someone chooses to ingest, they should do the math.
My dosage of one ounce twice a day is WELL below the amount to be used for glaucoma.

And it IS helping me.

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"Inspire is a support site, not a medical advice site.
I told the Original Poster of a non-traditional treatment that IS helping me. If there is additional risk to my health, it is almost certainly not tuberculosis. While on the traditional Enbrel, I was tested for TB prior to beginning and every year thereafter. Per doctor's orders.
Wishes for Relief to All,

If anyone were to tell someone here that it is safe to take Enbrel, would it be unsupportive of the community to suggest that prior to doing so they may want to have a long discussion with their doctor?
Inspire is a support site, but that doesn't mean that everyone needs to support bad, or even questionable medical advice when it is provided. The message that everyone should take away from my oral ingestion of glycerin is twofold;
1. It is not the safe non-toxic oral medication that many are claiming it to be.
2. Talk to your doctor before venturing down the glycerin oral dose path.

I agree this site should be about support and encouraging people to seek professional medical advice when appropriate.
It should not be about supporting those very few people that wish to give medical advice.

Will ingesting glycerin harm you, or me?
I don't know, but data indicates it can, and that you will probably want to talk to your doctor before heading down that path.
Heck he/she might actually tell you how much is a safe dose.
Truth is I don't know what your doctor will say, because I am not your doctor.

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