Stage IIIC Low grade serous adencarcinoma

Anyone have this? What did you take and for how long?

Thanks!

Report post

26 replies. Join the discussion

The standard first line of treatment for just about any type of ovarian, I think, is six chemo treatments three weeks apart, of carboplatin and taxol. But I'm not sure about the low grade serous....you'll hear from others on that. I had undifferentiated (probably fallopian)

Report post

I'm just curious because I read your story. Is this a recurrence for you or was this your initial diagnosis. I'm high grade serous so I don't know anything about your diagnosis. I know others here do and will chime in.

Report post

I was diagnosed with stage IV low grade in 2002. I had 8 rounds of carbo taxol, switching from taxol to taxetere after five treatments due to neuropathy. The original plan was to follow that with IP chemo, but I had too much scar tissue, so I did high dose chemo and stem cell rescue instead. I remained NED until 2008. It returned in left inguinal node so I had surgery followed by topotecan and avastin. I declined maintenance avastin. It returned in 2010, one spot on my liver, inoperable due to location. I am taking oral topotecan and pazopanib (phase I clinical trial) and the tumor is stable. Not sure if it's due to the chemo or if the tumor is just that slow growing. As one researcher said, " some of these low grade tumors grow so slowly, you could take broccoli and have stable disease". A patient is considered stable if there is less than 20% growth.

Very best luck to you!

Report post

I have some adenocarcoma and was treated with the standard protocol of taxol/carbo, 3 treatments before surgery and 3 treatments following surgery. Very successful with me. Possibility that my OVC could have been fallopian tube cancer. There are always discussions about this from surgeons.

Report post

I have low grade serous carcinoma , I have been on estrogen blocker for over 2 years. It's called Arimidex . It is keeping my ca 125 between 45 -22. I think the plan is to stay on it as long as my ca125 doesn't go up .
Best to all of you wonderful ladies!

Report post

Malmos' post reminded me that I have been on Femara since 2003. I started on Arimidex but switched to Femera due to arthritic symptoms. My tumor tested 80% estrogen positive.

Report post

To answer the question... no, I am not having a recurrance. My CA-125 is the lowest it's ever been. I am just reading more about people saying low grade is resistant to chemo and it has kind of freaked me out. I see a lot of people talk about having low grade carcinoma but not "adencarcinoma" so I'm not sure what the difference is. I'm just looking for some reassurance I guess. I have felt from the start that I would beat this and I'm sure I will. I just want to know what might creep up on me so I am ready for it. :-)

Report post

The older chemos attack cancer cells while they're dividing. Low grade tumors grow slowly, so their cells divide less often. So the response to chemo may not be the dramatic disappearance of tumors that people with high-grade tumors see. But that doesn't mean that chemo is hopeless.

Dr. David Gershenson at MD Anderson in Texas is a specialist in low-grade ovarian tumors, and several people here have gone to him for second opinions. It sounds to me like he's coming up with some good approaches. I would ask my doctor about the adenocarcinoma question -- it's a technical term which means the tumor cells have organized themselves like glandular tissue, but I don't know what that means in terms of treatment or how the tumor behaves.

Report post

A phase III clinical trial is about to begin, I believe, that is trying MEK inhibitors as therapy for Low grade ovarian tumors. Google Dr. John Farley and Ovarian Cancer. I'm hoping to get in this trial if my CA125 continues to rise.

Report post

My daughter has it. So far she has not been successful with chemo. Waiting to go into a clinical trial at Memorial Sloan Kettering. Even thinking about making a trip to MD Anderson in Texas who specialize with this type of rare ovarian cancer. It seems to be very difficult to treat.

Report post

Just an update, my daughter was accepted into a clinical trial at Memorial Sloan Kettering and she starts November 4th. It's not a chemo, they call it targeted therapy. I think it's a MEK inhibitor. It's a phase IB trial and it's at the maximum dosage.

Report post

Yes, my daughter also has low grade serous adenacarcinoma.

Report post

I would love to hear more about it, what she is taking, etc, thanks

Report post

Just an update. My daughter started the MEK inhibitor trial and was on week two when she developed a horrible rash all over her body and a raging fever of 105. She is still in Sloan Kettering recovering and they said all the tests they have done have come back negative so they are thinking it's a reaction to the MEK inhibitor. I was so happy that she got accepted into this trial then this happens. Hopefully, God willing, I will be able to take her home maybe tomorrow. The rash is still all over her body but they think it will be starting to go away since she is no longer taking the medication from the trial. I am wondering what they will recommend now for treatment to treat this "low grade" monster.

Report post

I have low grade serous adenocarcinoma, stage 4. I was DXed in 2006. I am currently on avastin and taxol every two weeks. Initially I had carbo/taxol for six rounds, then one year NED, Then doxil for two infusions, then a clinical trial with selumetinib for 15 months, then avastin with cytoxin, then avastin alone, then avastin with taxol. I've now been on avastin more than 3 years and may have to stop it due to side effects.
As someone said, I think chemo is just not as effective on low grade, not that it's not effective at all. It has certainly benefitted me. Every time I switched drugs, it was because the cancer was growing and new treatment stopped it.

Report post

I was diagnosed with Stage IIIc low grade papillary serous ovarian cancer, not quite the same thing, but still low grade. I was treated with the same 6 cycles of taxol/cisplatin, and am nearing my 1 year cancerversary and still dancing with NED! May you also continue your dance with NED.

Report post

where did you get your care? I have been trying, unsuccessfully, to find a selumetinib clinical trial
Do you recommend your doctor? Is he/she approachable? thanks, Kate

Report post

I am in southern ca and go to USC Norris for care. My dr is Lynda Roman and I think she is great. The trial I was in with selumetinib is over. I was in it for 15 months, part of 2008 and 2009. It was called AZD6244. I think Dr Gershenson from MD Andrson was the lead investigator, but it was done all over the country. It was a phase 2 trial and I participated at USC. The trial was specifically for low grade tumors. Good question about how to get the drug now. I don't know.

Report post

I just checked the study. John Farley was the principal investigator, not Gershenson.

Report post

Phase III should be up and running soon, but I haven't seen it yet. I don't think the drug will be selumetinib, but rather a different MEK inhibitor. Dr. Farley has moved to Cancer Treatment Centers of America. I wonder how that will affect the initiation of Phase III. I saw Dr. Gershenson's name on the information about Phase II, so unsurprisingly, he was involved. I am going to need this trial soon. CA125 has risen to 70...doggone it.

Report post

This discussion is closed to replies. We close all discussions after 90 days.

If there's something you'd like to discuss, click below to start a new discussion.

Things you can do

Support OCNA

Help the Ovarian Cancer National Alliance reach its goals and support people like yourself by making a donation today.

Donate to the Ovarian Cancer National Alliance

Discussion topics

Support OCNA

Donate to OCNA

Community leaders