My mother, who is 55, has a recurrence in her para aortic lymph nodes from high grade epithelial ovarian cancer, first diagnosed 2009. She had her lymph nodes removed a week ago and just came back home from hospital.
She also has the BRCA1 mutation, however, in my country docs seem to know nothing about any specific treatment for people with BRCA1 + OC. They say that BRCA1 is just one of the hundreds genetic mutations and at this point it just has to concern us, her children, regarding a future surveillance.
I searched for clinical trials in my country for BRCA1 related ovarian cancer, but had no luck. What local oncologists are offering mom is the same regime as before-Taxol and Carbo, every 3 weeks. So I tried to do a little research on my own and I read some promising results on a 2011 Japanese survey, saying weekly Taxol and Carbo proved better PFS than when administered every 3 weeks.
On the other hand, there are some articles about Taxol resistance in BRCA+ patients, since a normal BRCA function was required for Taxol to work-http://cancerres.aacrjournals.org/content/64/12/4148.full and others.
At the same time, recent studies imply that a second mutation may occur in BRCA+ recurrent ovarian cancer cells, thus making them resistant to carboplatin.
As you can see, I am completely at a lost, and my questions are to all of you BRCA+ ladies facing a recurrence- what kind of treatment were you offered and did your oncologists have in mind your BRCA1 status when choosing the optimal treatment for you?
Did you participate in any clinical trials on PARP inhibitors and do you know about any trials, that are currently recruiting BRCA+ patients?
I read very promising results about Doxil and Carbo combination, were any of you ladies offered that kind of treatment as one more suitable for your BRCA+ status?
Thank you in a advance for your responses!
Edited May 22, 2012 at 10:19 am