My husband, 55, was diagnosed with GBM in March 2012. It presented with a seizure (the only one he's ever had) and is located in the right temporal lobe. He did 6 weeks of radiation and Temodar, and we got terrific news on the follow up MRI. Not only was there no new growth, but the tumor shrunk! We are thrilled! He then began Avastin and takes Temodar the first 5 days of each cycle for the next year. He's taken Avastin twice now and will begin the second round of Temodar the end of the month. So far, he has tolerated this combo very well except for fatigue. He is on long term disability from a job and company he's been with for 23 years. He's unable to drive due to having had the seizure and still being on Keppra for that. Prior to GBM he was extremely active, still playing tournament softball, which he also can no longer due. Keeping his spirits up has been a challenge, but I'm trying! The reason for this, my first post, is to reach out to anyone else in our same boat. I am a two time breast cancer survivor myself, but this is my first experience with brain cancer. While I realize that everyone diagnosed with GBM can respond differently to the treatments, just wondering mainly if the fatigue is cumulative as the treatments continue. Or, really, just what to expect going forward. Any feedback will be most welcomed.