The onset of von Zumbusch pustular psoriasis can be abrupt. The condition begins with the development of reddened, painful and tender skin over much of the body, followed in a matter of hours by pustules. Over the next 24 to 48 hours, the pustules then dry and peel, leaving the skin with a glazed, smooth appearance. A fresh crop of pustules may then appear. Eruptions often come in waves that last days or weeks.
Von Zumbusch pustular psoriasis is associated with fever, chills, severe itching, dehydration, rapid pulse rate, exhaustion, anemia, weight loss and muscle weakness.
Individuals experiencing the symptoms of von Zumbusch pustular psoriasis should go see a doctor immediately. Treatment for von Zumbusch pustular psoriasis often requires hospitalization for rehydration and initiation of topical and systemic treatments, which typically include antibiotics.
Von Zumbusch pustular psoriasis can be triggered by an infection; sudden withdrawal of topical or systemic steroids; pregnancy; and drugs such as lithium, propranolol (brand name Inderal) and other high blood pressure drugs; iodides and indomethacin (brand name Indocin).