starting methotrexate today

I took my first dose of methotrexate tonight. I took a 25mg benadryl along with it in the hopes that would help stave off nausea should it occur. I am praying that I will have no ill effects from the medicine & that it will help me get better. I am sick of hurting all the time & sick of having so much trouble doing mundane things like blow drying my hair, pushing a shopping cart, typing or worst of all picking up & playing w/my children. I had a pretty bad flare up that started a couple wks ago. The rhuem put me on steroids. I will start tapering down off it tomorrow. I dread coming off the prednisone b/c I know once I do, the pain/swelling will come back.

Praying something will start helping soon.

Off to bed to try to get some sleep.

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Good luck with the methotrexate. I have taken it for a year and it has been extremely helpful for me. I have had little side affects, I have always taken it with a little food. Usually have a poor appetite for a couple of days, ok for me as I can stand to loose weight. The methotrexate takes a few weeks to begin to make a difference. Good luck with it.

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I started methotreate this year too and so far no side affects. they started me on a small dose at first then increased after 3months of being on it cause I wasnt improving. I'll will be seeing the rheumatologist next month hopefully my labs will show more improvement.

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I fought and fought my doctor about the methotrexate!! I was hung up about it being a chemo drug!! I probaly fought if for a couple of years but once I went on it (I had no problems) I could have smacked myself for not getting on it sooner. For me it worked great and was on it for years!! My doc said I would not only notice the pain decreeasing but my skin would soften and that it did. Every once in a while I would get a tiny mouth sore....like an irritated taste bud...but I also took folic acid. Good Luck with the methotrexate!!! Keep us posted! ;-)

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my husband takes methotrexate as well and it's hard to tell whether some of his remaining symptoms (fatigue mostly) are mtx treatment side effects or unresolved disease symptoms, but it certainly seems to do it's job.

his doc put him on a folic acid + b12 supplement to counter methotrexate side effects (theralogix MTX support if you want to google it)

hope it's all good for you :)

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I too was on Methotrexate didn't see much difference as my numbers continued to climb until I eventually tested positive for SD.

When I starting see Dr. S (Rheume Spec) in Albany NY, he immediately took me off of it. He said the type of SD I have when taking Methotrexate can sometimes cause Lung Involvement.

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Well, the first dose went better than I thought it would. Had some nausea, loss of appetite & felt hot/flushed most of Sat but other than that was ok. Hope the rest goes as smoothly & hope to start seeing some relief soon. How long before you started noticing results? Does the metho help w/the fatigue at all? I'm currently on prednisone for my most recent flare until the metho kicks in. Sure hope it kicks in soon. This is for the birds! I'm sick and tired of feeling sick and tired. Thanks everyone for the info and the encouraging words!

Jen

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I am into the Methotrexate and Prednisone for almost two months. Also taking Folic acid to help deter any side effects. Got the prednisone "hump" in the first 30 days, so now we also added Boniva for several months. No side effects from the methotrexate that I can pinpoint - but the past week or two having horrible stabbing pains in my shoulder area - but that's where my TA is blocking circulation. Right now trying to figure out what that is.....

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Jen -
I've heard of these "flares" - how does that affect you? I'm having some sharp joint pains...rhmy says is not the drugs / Vasc. md says its not the disease....I'm thinking that is "my" flare-up??

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For me it's swelling in my rt arm coupled with extreme joint/muscle/ligament/tendon pain, & overwhelming fatigue. I feel like I've been run over by a train. My body hurts. My rt arm particularly will swell-the muscles themselves, joints (esp in my elbow, wrist & fingers) & the tendons/muscles/ligaments get extremely tight. My hand will curl into a fixed C position. My arm will hurt so bad that even a sheet brushing on it will evoke tears. Which is my night tonight. Something simple may set if off such as picking up my son (age 4), pushing a heavy grocery cart, working out (which I stupidly did today-rode the bike for a half hour), blow drying my hair, reading (because it involves bending my arm & holding up the book for an extended period of time. Stupid things like that. Sometimes I don't know what the heck set it off. There are times when the pain can mainly be in my arms or tiems when the flare is really bad & every joint/lig./tendon in my body is swollen & painful. It's the most frustrating thing. As of yet I am still largely undiagnosed. My rheum says he's "calling" me "seronegative RA w/unspecified connect. tissue disease. b/c he has "nothing better that fits." Translation: "I don't know what the hell is wrong with you but we'll call it this & try treating it somehow. " Yay me! Feeling frustrated & bitter tonight. I just want to know what is wrong w/me and how to treat it so I can get back to living a normal life. I want to play w/my boys (4 & 6) and not worry that I may hurt terribly for days afterwards. I don't want my boys to be scared to touch me b/c they "might hurt mommy". I want to blow dry my hair without having to stop & rest every 2mins & then hurt for a day or 2 after. I bet people think I'm just lazy & don't wash my hair much b/c I don't care. Not true-I'd love to wash my hair on a daily basis but I can't handle blowdrying it & going to the salon for a blowout every couple of days is not very cost effective. I'm not quite to the stage of the blue haired ladies who put so much spray net in their hair that they only have to get it fixed once a week! Not quite-but @ this rate I feel like I may get there long before I'd like!

Alright, pain meds & the hot epson soak/heating pad are finally kicking in & the pain is becoming more tollerable so I am heading to bed. I hate this whole cotton picking mess & everything it robs us of. It really, really sucks.

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your case sure sounds a lot like mine....look up "Takayasu Arteritis" - that is my diagnosis. Started iwth numbness in my hands - with pains shooting up my arms. I too cut my hair off as it was too painful to get it washed and rinsed thoroughly. By the time I got out of the shower it would be throbbing / stabbing pains all the way to my shoulders......

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How did you get a dx? What doc did you see? Rheum, vascular?

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sorry - what's dx?
I started with a Blood disease specialist - as my white blood cell count and platelets have been up for 18 months or so - then to Neurologist - ruled out carpal tunel/ then to Neuro-surgeon - he scheduled me to disk replacement surgery / to second neuro surgeon - he said symptoms weren't matching x-rays & mri for disk surgery - realized I didn't have a pulse or blood pressure in that arm - send me to vascular specialist / had angiogram 2 days later - to rheumotologist next day - to confirm TA diagnosis. In both arms - arteries are shut off at top of my arms due to inflamation. Scheduled for first artery by-pass july 19th on left side. I'm at the Medical Center in Houston - they get about 2 cases per year - very rare.

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Wow! So did you get swelling & pain in your arm along w/the numbness? Did the muscles/tendons/ligaments feel stretched tight & rock hard? Sorry for the 21 questions-desperately trying to figure out what's wrong w/me! My rt arm esp will get really sore/inflamed after minimal use. I bit the bullet today & took my kids bowling & I am hurting so bad tonight it isn't even funny! My arm will freq. be warm to the touch in the forearm & above my elbow but cold to the touch in the hand & fingers & will have a dusky red/purple color as if someone tightened a bp cuff around it. My hand will swell areound the knuckes, wrist & in my forearm. It's crazy!

I will be praying your surgery goes well. So once they do the angioplasty, will that take care of the problem for you? Hope so!

Jen

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Hey Jen - if your's is anything similar - Don't overdo! My arteries are totally closed off at the to of my shoulders (sub-clavicals) so I get very poor circulation. the pain comes from the fact that you are doing something, and the blood supply cannot re-stock the blood in those areas fast enough. Also from the angiogram, this has caused an enlarged heart situation - so I can't really do much of anything at all until this is resolved. I kept telling people it felt like I had no blood circulation at all in my arms - and that is what it was. Hopefully after the next angiogram, when they do the first artery by-pass - it will go back to normal - but my disease is in-cureable, so I will be on meds for maintenance for a long time - originally he told me at least 2 years.

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I started methotrexate 2 weeks ago and thankfully didn't get ill. I'm weaning off prednisone now and I'm noticing that pain returns more quickly but I hate the drug so I'm willing to suffer.. any thoughts?

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Cheer- I'm still weaning off the pred. I'm down to 10mg daily. What dose were you on w/the pred? I do notice as I taper down the pain is more intense. I'll take my 2nd dose of metho. on Friday. Praying all goes well like last wk & there are no major side effects. I'm hoping there will be enough of a bridge between the pred & the metho that I won't have a big increase in pain once off the prednisone like I did on the plaquinil. Guess we'll have to wait and see. I'm just ready to have some more normal days where I can do boring, mundane, stupid stuff like dry my hair w/o pain or have my kiddos hold my hand w/o me wincing.

Jan-Dx is nursing shorthand for diagnosis. I used to be a nurse & old habits of shorthand die hard. Yes, overdoing it seems to throw me for days worth of a loop! The hard thing is knowing just what is going to be overdoing it. Was it when I did my hair, was it when I picked up my son, was it spending a 1/2 hour reading & having my elbow bent while holding the book, was it just stirring dinner last night. Seriously so many normal, everyday activities seem to set it off. The hard thing is I was born w/cerebral palsy and my lt side is fairly weak so I use my rt side for everything. Now w/the rt side going out, I'm at a loss for what to do now! My lt arm/hand is getting somewhat tight like my rt but is not nearly as painful & inflammed as the rt one. It makes sense though that the rt would be more inflamed b/c it's the side I use the most.

Has anyone tried & had success with accupuncture? I'm getting the the point I'm willing to try just about anything!

Jen

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Hi all, sorry but i have not been on this site much,been in and out of hospital a lot. i am not one really to let people now about my problems ,anyway, i have been taking Methotrexate for about 4 years, which i always take on sunday ,monday for some reason i feel really low,not even wanting to get out of bed. but you do in the end.i have also suffered with twitches and body movements which i have no control over .i also have rheumatoid arthritis, and isaac syndrome. i had to give up plumbing and heating which i loved doing for over 20 years . what i am trying to say is that when it seems really bad, just try to think of something good and if it does not happen to you it might happen to some one else ,sorry if that does not mean anything. but i am not very good at this sort of thing.

thanks Theplumber

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you know....i've been having more severe pains since I went down to 20 mg of Pred. also....didn;t think that may be the cause....thanks! I started at 40 mg - then 30 after 2 weeks, and now down to 20 after a month. I already have my instr. to go to 1.5 in another 2 weeks - but I'm planning for surgery - first artery by-pass on 7/19 - so i think he's weaning me for that. Have not had any issues with the Methotrexate.....pharm said to take it with high protein breakfast.

Plumber: there is NO right or wrong way to do this - its a means to reach out and visit - or just talk to someone who may be going through a lot of the same things.....

I met another lady through a TA site on facebook and talked to her for an hour last night. She said a lot of the flare ups or pains happen when inactive, as body needs to move for circulation - i.e. sitting for long periods, travel, - mine right now is sleeping....get up really early in a lot of pain!!

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I am wondering if anyone can recommend a good rheum in the Atlanta GA area who is familiar with the AP therapy? My doc at UAB is not a fan of it, but I am willing to try it, w/ or w/o her. Are these drugs related to the AP therapy taken orally?

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I have not rec's. You might check on the roadback.org I think that is the site. There should be someone there that might know.

Good luck!

Jen

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