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LIVER BIOPSIES-Placed in Formalin-Does it damage sample??

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First, I want to say a VERY BIG THANK YOU! to Eva Roberts & DR. Michael Schilsky for your "Diagnosis & Treatment of Wilson's Disease" AASLD Practice Guidelines. It has answered so many questions for me. I just had my liver biopsy done. After my liver sample was removed I asked the physician to show me my sample. He held it up and the three samples he took were floating in a liquid, not sure what it was, could have been (water). After reading Dr. Roberts report I noticed there is a specific protocol for handling the samples. Since my sample was not put in a dry container will I have a false negative for my results? Thank You!

UPDATE! I just got my results from my Doctor the pathological diagnosis states that there is no sign of copper based on a copper stain. I did note that the Gross Description stated that the biopsy was suspended in Formalin. The pathological diagnosis is negative for copper, but there was no value for Hepatic copper content (no dry weight noted) I can't believe they found no copper. Something does not seem right. My physician is sending the sample for a quantitative copper study.

2 replies

I think the liquid is some sort of fixative. It keeps the sample fresh until it gets to the lab. It shouldn't affect the results. My specimen was also put in a little container with liquid.

If it was put in a dry container, the sample would dry out and they wouldn't be able to section it off to test it.

Thank You! DR. Michael Schilsky for answering my question; that formalin does not affect the specimen.

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