Hyperthermia prostate cancer treatment

I was diagnosed in July13 with Gleason 3+3 and 5 of 12 cores positive. Problem area is that both left and right Apex showing 50%. I went to UTMB to have 3tMRI and see if Focal Laser Ablation (FLA) would be an option. Dr. Walser did not seem to think I would be a good candidate. He did however agree to take a second look in 5 months, he wants me off testosterone, and to take antibiotics before 2nd MRI, to see if the images clear up. When I got home a friend had sent me an email about 3 male members within her family that had traveled to Germany for Hyperthermia treatment. And all 3 had very good results. Has anyone heard of this treatment? I know the Germans are well ahead of us here in the USA in the treatment of our beast, but would really like to hear from some more guys that have experienced it.

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I never heard of Hyperthermia but I will certainly investigate. I face rising PSA after radiation at Stanford three years ago. Thanks for sharing.

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HIFU, LFA, RFA and IRE are all forms of hyperthermia - they use different energy sources to increase the temperature of the tissue and ablate the gland. Cyro is a form of hypothermia, using argon or liquid nitrogen to freeze the tissue.

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is hyperthermia is new later stage of psostate cancer??

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HIFU should be available in the US after the first of the year - it is applicable to focal and radical therapy. I recently attended a lecture given by a HIFU practitioner and came away thinking it is something worthy of consideration because of alleged fewer side effects. I briefly write about this and other forms of focal and radical therapy in my small book; Prostate Cancer: Asking the Right Questions. It is very important that you become your own advocate, and this requires that you get informed. Asking the right questions greatly increases your chances of having a good outcome. This is why I wrote the book. It takes a look at prostate cancer from the patients perspective, and provides you with the basic knowledge needed to begin your own investigation - which is a must. You see prostate cancer treatment is big business and every practitioner is trying to sell you their form of treatment. This is because the medical community has not endorsed a specific approach. You can learn more about me and my little book at www.prostatecancerquestionstoask.com .

Best of luck,
Tom

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Tom, I was involved early on in a company introducing HIFU into the U.S.A. That was 15 years ago and still no approval. The criteria for treatment rules out most men because if you have a prostate larger than about 25 grams you are excluded. This limited treatment to young men and few young men have prostate cancer. My old company hyped this technology for years, but I don't foresee it being a treatment approved in the U.S. for a long time and then to only a small group of people.

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I was told that HIFU is likely to get FDA approval after the first of the year - maybe this is not correct. We have a Dr. Chopp (yes that is his name) in Austin, Texas who has been offering HIFU in Cancun, Mexico for about six or seven years. I have a friend who went that route. Chopp has treated about 200 patients and (I think) claims never to have had a reoccurrence. He also quotes side effects statistics that are extremely attractive. At a lecture by Chopp a recent patient of his took questions. This man had his prostate destroyed in the morning and went out to dinner that night. He also claimed to have an unmeasureable PSA and no side effects. Of course this is all anecdotal and doesn't mean anything. I didn't know about the 25 gram limit, but what seemed attractive to me about the procedure was its use in focal therapy. HIFU seems to be a low risk procedure for locally destroying a tumor. I think focal therapy will become quite common in low Gleason score cases in the future. Time will tell.

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My husband was diagnosed in July 2013 with advanced PC, Gleason 9, 12out of 12 positive, 10=5+4, 1,4+5,1-4+4, his MRI showed extracapsular extension, involves seminal vesicles, posterior bladder wall, w/ "extensive pelvic lymphadenopathy" he was diagnosed at MD Anderson, Texas. His PSA was 49. Needless to say he had been doing ALOT of reading and research. He was told they wanted to start him on the HMT. He was hesitant and we went home to think about it. He read some books and articles about Cancer treatments around the world and concluded Germany was leaps and bounds the US in there treatment protocols. He inquired into, clinics in Germany, Switzerland, Mexico. He started having difficulties with urinating and called the Dr. At MDA, they suggested he start the Degerolax to give him some relief until he decided what he was going to do. It helped. He decided on a Clinic in Germany and we went the end of August. He did Moderate hyperthermia, local hyperthermia every other day, magnetic field Therapy, IV infusions of high dose Vitamin C, stuff for his Lymph system and some other therapies. We met cancer patients from all over the world and heard some very encouraging stories. Dr. Alexander Herzog has an excellent reputation. He has done some of the most Hyperthermia and speaks/teaches Internationaly and has written several studies regarding hyperthermia. When we returned beginning of October,we went back to MDA for follow up and another Degeralax(recommended also by Dr. herzog) my husbands PSA, was "7"! Oncologist was thrilled. Went back mid Nov. for another MRI and showed " slight decrease in size on Tumors ( positive results), we are still early on this journey. But at least we are heading in the right direction. We will head back to Germany next week to start treatment again. Andrew Scholberg has some excellent books about German Caner Clinics. He has visited several at different times and gives an unbiased review of them. There other resources out there too. I know everyone's choice of treatment is a personal choice. The good thing, I guess is. He was not given the options here .

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Blr,

Very interesting!

tleih

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Folks, I had week-long hyperthermia treatment in Germany on January 2013, approx 10K USD with airline tickets. On Dec 2012, diagnosed with a Gleason of 4+3 with 4/12 cores positive, PSA 10.1 all in the right prostate lobe with no leakages - CT scan/bone scan normal. Uro surgeon and radiologist told me Intermediate prostate cancer and the usual options given - surgery or radiation. Not too keen on either one, I researched alternative options including hyperthermia in Germany. Went to Brannenburg, Germany (south of Munich) late Jan 2013 and received local hyperthermia treatment plus other treatments to increase my immune system for a week, similar to what Blr mentioned in her posting. Also given a 1-month dose of hormones before I left with no side effects. Apr 2013 PSA test showed 2.6. In June 2013, took a 3-D Parametric MRI which showed 'large decreased in tumor size" and PSA of 1. Fast forward to December 2013 and my PSA is now 7.96 with Gleason 8 tumors in 2 cores and Gleason 7 in 4 cores per biopsy and Endo-rectal MRI - in both lobes but supposedly confined to the prostate. Bone and CT scans normal. So what to make of this...my take is that hyperthermia worked but obviously it did not kill remnant PC cells floating around my prostate. Recently spoke with my German doctor, very nice and compassionate gentleman, and he believes another hyperthermia round with radiation and/or hormone treatment can take care of this. No decision yet and at this time, researching standard US treatments to improve on my life expectancy chances given the Gleason 8 - top priority. Also looking at USA alternative PC treatments as well - lots out there.

Bottom line: not a doctor, but hyperthermia seemed to have worked for me but I failed to closely monitor MRI and PSA results - I probably should have also returned for additional treatment as well. BTW none of my USA doctors knew of hyperthermia treatment or seems to me, cared to learn about it. If you can spare the approx $10K or more, worth considering - not covered by US insurance companies. Suggest to Google www.germancancerclinics.com or local hyperthermia cancer treatment in general for more information.

I would agree with Blr posting - hyperthermia is an encouraging PC treatment though is FDA approved in the USA only if accompanied by radiation. Per internet research, believe Dr Bicher Clinic in LA, California or Cancer Treatments of America practice this FDA approved method of non-local hyperthermia - pls confirm. Very happy to hear that Blr's husband is doing well - only wish them the best. Pls share how your recent treatment in Germany went. Keep the faith and keep the hope !!! Cheers...

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In April 2013 I had hyperthermia at Arcadia Clinic in Kassel, Germany. Consisted of whole body hyperthermia weekly and localized hyperthermia to the prostate daily over a one month period. It was coupled with IV of Artesunate and Amygdalin (laetrile). Very good experience, which I credit with keeping my Gleason 9 (4+5) stable...still no bone or lymph mets after diagnosis in Aug 2012. Will do another round of hyperthermia here in Vancouver, B.C. soon. This time I will choose my IV solutions based on results of the 'Greece Test' which will show how my cancer will respond to various natural substances before they are injected.

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Novatimo - thank you for sharing your experiences. Would you mind providing the name of the hospital in Vancouver? Any other info you have would also be appreciated. Did you have surgery or any other procedure prior to the hyperthermia?

I have only recently started researching this treatment - I find it very interesting, but there isn't much data available that I have found.

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Tim-B: To the best of my knowledge, hyperthermia is not offered in any local hospitals here in Vancouver, B.C. It's offered through the office of my naturopathic oncologist, Dr. Walter Lemmo. It's also offered by Dr. Parmar out in Fort Langley, B.C. Hyperthermia (plus a host of other immune enhancing treatments including mistletoe) was my chosen substitute for surgery and radiation, which did not make my famous prostate specialist (Dr. Gleave) here in Vancouver happy, whose only solution was IMRT and possible surgical removal of the bladder! We've since parted ways and I'm working with a more open medical oncologist. I'm feeling well, PSA is low, MRI and PET show stable prostate and no evidence of spread.

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Very interesting (truly) - I learned more on this topic from Dr. Lemmo's website than I had gleaned from the few articles I could find elsewhere. Alternative treatments typically are controversial with some (many) - but, that does not mean that they cannot be effective.

I am glad to hear you are responding well and would be interested in any other information in this area and your own experiences as you move forward. It takes confidence and determination to take charge of ones health as you have done - I wish you the best.

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Novatimo...we also ditched Gleave. Unbelievably narrow-minded doctor in our opinion. My primary concern over hyperthermia (which is NOT HIFU), comes after reading three separate studies that show it ablates androgen receptors and "therefore can advance the progression of aggressive prostate cancer." I have attempted on numerous occasions to get the studies authors' to advise precisely how ablating a hormone receptor can accelerate disease (I would have thought the opposite, given that some popular pharmaceutical therapies for advanced PCa focus on downregulating the androgen receptor. I assume that this is when it is used as a stand-alone therapy and not in concert with radiation or chemo. It's very frustrating as we would like to have it. We see Parmar and we respect him greatly. Dr. Sasha Smiljanic is our new oncologist from LGH and he is excellent and more open minded.

Also, I'd like to point out to the lady up there who went to Germany that hormone therapy (Degarelix) will also cause PSA to drop and tumours to retract, since they are no longer getting the testosterone that they need to grow. I don't want to be a Debbie Downer but I have spent much time investigating hyperthermia (and I'm a 35-year veteran medical journalist who does a lot of research). I do so very much want it to work for my husband but I have to know more about the consequences of this androgen ablation first. I am guessing that, since a portion of cancer remains hormone receptive (and therefore needs cell receptors to be held down) that the risk in ablation means this portion of cells will become refractive and therefore more aggressive. The answer then would be to go off bicalutamide (Casodex) but not Degarelix or Lupron, which block the production of testosterone and not its actual uptake by the cells and have hyperthermia and hope it knocks them all out.

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Moonlitnight: Have you spoken about your hyperthermia concerns to Dr. Parmar or Dr. Smiljanic?

"Sasha" is also my medical oncologist who I went to after Gleave berated me and my husband for our decision to pursue hyperthermia before doing IMRT. Anyway, the hyperthermia hasn't seem to negatively effect the aggressiveness of my cancer. If anything, ever since getting hyperthermia my condition has stabilized, though in truth, I'm doing many more things than just hyperthermia. My radiation oncologist does not seem concerned that I've done hyperthermia instead of IMRT.

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Hi Novatimo,

I have brought it up a few times with Dr. Parmar. He was not aware of these statements regarding advancement of disease, made in all three studies...I have not brought it up with Sasha. We see him Feb 4 so I will ask him if he knows anything about it and to look into it. It is of course speculative and in vitro, not in vivo. We are also "doing many more things than hyperthermia" (to put it mildly...) We were practically ridiculed by Gleave due to our desire to incorporate a healthy diet and proven supplements. I stood up and left. My husband lost 45 pounds after Dx in Feb last year, to get healthy. He is on a lot of supplements and sticking to as vegetarian a diet as possible. We also see Dr. Adam McLeod for energy treatments. He was excellent at sorting out possible conflicts among our supplements as he is also a molecular biologist.

Best to you. Maybe we'll cross paths in Sasha's office one day - and won't even know it.

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This is so funny. I too am seeing Dr. Adam McLeod for energy healings! Sounds like we're both taking the wholistic, integrated approach that people in conventional medicine have no concept of. Maybe we should do more than hope to cross paths. We live near Science World and would be happy to meet up if you'd like. Feel free to call at 604.629.9179. Tim

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Tim, this is really something. We are on the North Shore. I will chat with my guy tomorrow and yes, let's do it! We clearly have lots in common. :)

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