Thyroglobulin Levels

Hello There!

I got my first blood test report and here goes:

Thyroglobulin Ab = <20 intl-unit(s)/mL
Thyroglobulin Level = 5.5 ng/mL

Seems minimal and pretty good! Can anyone tell me what the ranges are for these?

My new endo is quite nice and seems pretty good so far although she is not a cancer specialist. We discussed RAI and she does recommend it because my tumor was larger than 1.0 (it was 2.2cm), but mentioned I could also wait a few years until after having children. Even though it was completely encapsulated, she still suggests I go for RAI... :(

I'm on Synthroid 100mcg and feel pretty darn good. Can't complain.

Happy New Year. Let's make 2012 the best year ever!

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cute pic! you look gorgeous! :))

i think i have read <10 ng/ml is good for Tg reading....but info on Tg levels is hard to come by, i find.

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oh & ablation is no biggie, if you can get thyrogen....don't sweat it :) it's great you have time to wait. i had time too....it was really helpful.

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My lab report said that normal Tg for someone without a thyroid was less than 2. It might be different for a different lab though. I'm also not sure if that was stimulated or not. Glad you're feeling well, and hope that the rest of your treatment is smooth sailing too!
Kim

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what is the difference between stimulated and unstimulated? What does that mean and what would that indicate?

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Ideally, your thyroglobulin should be <0.2 ng/mL (both stimulated and unstimulated), but that usually happens only after TT and RAI. I'm sure your doctors want you to have RAI in order to give you a reliable tumor marker, but I've heard of people forgoing RAI and having their post-TT Tg be their tumor marker. I wouldn't rush into making a decision, and I'd go for a second opinion to see what another doctor suggests.

thyromom: A stimulated thyroglobulin means you are hypothyroid (TSH > 30 by withdrawal or Thyrogen shots) and an unstimulated thyroglobulin means you are still on your hormone and have a suppressed TSH. The stimulated Tg is more sensitive and accurate compared to the unstimulated Tg since any thyroglobulin "wakes up" when your TSH is high. Thyroglobulin can be "hibernating" when you are on hormone, but it's still beneficial to get that test done as well.

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My endo wants my stimulated Tg level to be <2 (it's now 0.9, so we're happy). My unstimulated Tg level is undetectable.

My understanding, from long talks with my experienced endo, is that the Tg level can simply indicate thyroid tissue remaining in the thyroid bed post-TT, rather than persistence or return of cancer. Most surgeons err on the side of leaving MORE thyroid tissue behind, rather than risking damaging your laryngeal nerve or parathyroids. This isn't an area of your body where they want to take more out than is absolutely necessary! So, according to my endo, only 1 out of 100 TT's actually result in a complete removal of all thyroid tissue. Thus, most of us still have detectable Tg readings post-TT, unless we have the ablation procedure done to destroy any remaining thyroid tissue.

That said, I have to question whether it is worth it to go through ablation just to bring the Tg level down, if there is no indication of disease. With a stimulated Tg level of 0.9, and with no evidence of disease, I have made the decision to forgo RAI absent new problems.

AND -- apparently, the Mayo Clinic has developed a new "ultra-sensitive" Tg test that provides really good Tg readings without stimulation. I am having that test done in February, to add one more piece of data to the puzzle. My blood draw will be at my local hospital in SF, but the blood will be sent to Mayo for testing under their new protocol. Something else to think about!

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"AND -- apparently, the Mayo Clinic has developed a new "ultra-sensitive" Tg test that provides really good Tg readings without stimulation. I am having that test done in February, to add one more piece of data to the puzzle. My blood draw will be at my local hospital in SF, but the blood will be sent to Mayo for testing under their new protocol. Something else to think about!"

Very interesting! You'll have to keep us posted on your results (if you want to) :))

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Thank you Jani72! That pic was taken on my wedding day!

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