After TT in 2/2009, my pathology showed my thyroid had a 3.5 cm Papillary/Follicular tumor.
Not a single doctor has addressed the 'follicular' aspect of my pathology. But each doctor (2 endos and the surgeon) strongly recommended RAI ablation for me 'some day'.
It was not until here, that I had even heard of follicular variant. So, I started researching and found that there seems to be new and invigorated research studying different aspects of FVPTC.
I found this study interesting and an encouraging sign that the medical community continues to explore thyroid cancer.
This is just one study in the mix of many. It is not meant to alarm, only to inform. I know I will be inquiring to my physician about my particular aspects of follicular characteristics.
"Context: The clinicopathological characteristics and the molecular features of the follicular variant of papillary thyroid carcinoma (FVPTC) remain controversial.
Objective/Design/Patients: In an attempt to clarify such controversies and to find whether or not FVPTC cases share the molecular features of follicular tumors,...
We think there is enough evidence to rule out the idea that FVPTC, as a whole, should be considered as a subgroup of conventional PTC (Fig. 4A⇓), and we would favor, taking into consideration the metastatic pattern (4, 5, 6, 7, 8, 9) and the molecular features described in the present study, the concept represented schematically in Fig. 4B⇓.
The study of a larger series of FVPTC with long follow-up and detailed data on lymph node and lung metastases is necessary to find out the clinical significance of the occurrence of the three genetic alterations (PAX8-PPARγ rearrangement, RAS mutation, and BRAFK601E) per se, or in association, in FVPTC. It will be interesting to find out whether the tendency for blood-born metastases of some FVPTC may be ascribed to a particular molecular profile of the tumors, namely to the presence of PAX8-PPARγ rearrangement (see above). In the affirmative case, we would suggest that such encapsulated FVPTCs with PAX8-PPARγ rearrangement should be classified, for practical purposes, in the group of FTC rather than as a variant of PTC (Fig. 4C⇑). "