I suffer from a pretty severe form of palmoplantar pustulosis, also known as palmoplantar pustular psoriasis, since 2006.
I was on cyclosporine for more than two years and after a very good start the desease worsened pretty hard (after the second year).
I had pustules all the time and all over hands and feet (about 150 on a single hand), and my skin was broke and red as hell (felt like burnt!). Ok, you know what kind of hell I'm talking about.
Then I had to stop cyclosporine due to its toxicity, so I tried the narrow band without success. Cortisone would do almost nothing. Protopic would help a little, nothing major. My skin continued cracking and even bleeding.
Desperate as I was, after having heard of it for a long time without getting convinced, I decided to give the biotin - japanese thing a try.
Wtf, it is affordable and has no known side effects, I thought It really couldn't hurt.
Well, I am entering the 3rd month of oral daily assumption of a giga quantity of biotin and no, the desease isn't gone for good, but if three months ago on a scale of ten the desease was at 10, now it is at 4, even 3 sometimes I would say. Also consider that in the meanwhile I had to stop cyclosporine, so, in proportion, the actual positive effects could well be even bigger.
I would post two photos of my left hand before and after but I don't see here tools to do that, maybe it is not allowed on here.
By the way my hands are incredibly better now, and also my feet, after a rough start, have started to get better around a couple of weeks ago. Four months ago, when still on cyclosporine, I had like 150 pustules on my left hand, now I can see a couple at max. Sometimes I see more pustules, like around ten per hand, but never as formed and big as they used to be before biotin. And they don't turn red-brown at the end of the cycle. My skin is still a bit reddish, and not perfectly healed, but I haven't had a single crack in 30 days now, and this NEVER happened before. My quality of life seriously changed for the better.
Now, I was scheptikal as many of you are about this biotin thing, and I do perfectly understand you people, but I had to share my experience. I know what incredibly painful condition this is, and seriously I thought I would try to help, with no second intentions. I work in the cinema biz so I really have no interests whatsoever in biotin being sold. I also know what a placebo effect is, and how differently the desease works on each of us, so I am not saying this is the cure. What I am saying is that, given my personal experience, it definitely IS worth a try.
I would be very very very happy if I could help out even only one single person who's on this incredibly annoying desease. I’ve been there, I still am, and I so tragically hate it.