Candida cause of psoriasis???

Hi, I am David aged 38 and have had plaque psoriasis for about 12 years on the palms of my hands, in ears, and lower back, and have tried many things, but think that possibly Candida Albicans could play a role in the cause of psoriasis???

Anyone whoever you are please feel welcome to join in and share your thoughts about this.

Below are my ideas so far on possibly how Candida Albicans could link to psoriasis. My ideas are researched from Leon Chaitow's book "Candida Albicans - Could yeast be your problem?", internet sources, Allergy UK, doctors and a reflexologist.

1. Candida Albicans is in everybody in a yeast form and it is kept under control by our friendly bacteria. Candida Albicans helps fight against harmful bacteria.
2. Antibiotics are taken which kill off the friendly bacteria in our gut, but the Candida Albicans are not affected as they are resistant to antibiotics.
3. As the friendly bacteria are now wiped out, the Candida Albicans is no longer regulated and so starts to grow out of control creating lots of colonies. This is called Candida overgrowth.
4. The Candida changes from a yeast form into a mycelial fungi form producing Rhizoids. (If Biotin is present in the body, this transformation is harder for the Candida to do).
5. The Rhizoids are roots which hook deep into the stomach lining and damage it by causing tiny holes. This is known as Leaky Gut Syndrome (LGS).
6. Candida toxins such as Zymosan, undigested oversized proteins and fats get into the bloodstream through the damaged porus leaky gut.
7. Because of these foreign objects in the blood stream the immune system sees them as antigens and attacks them. The Thymus gland then sends T Lymphocytes (T cells) to attack the antigens which it does with its receptor.
8. Normally the T cells that attack the body's own proteins are eliminated in the thymus, but because these antigens are now in the blood stream the immune system does not recognise them as the body’s and therefore allows the T cells to attack them.
9. One of these T cells called helper T cells become activated when presented with a peptide antigen.
10. Once activated, the t Helper cells divide rapidly and secrete small proteins called cytokines which are Th1, Th2, Th3 and Th17.
11. The helper 17 (Th17) then further secrete cytokines to facilitate a different type of immune response called interleukin 17 (IL-17).
12. IL-17 acts synergistically with tumor necrosis factor TNF and IL-1 which are cytokines.
13. One tumor necrosis factor called TNF Alpha can stimulate cell proliferation.
14. It possibly does this by interacting with kerytinoxyte skin cells in the basal layer of the epidermis accelerating the skin cells which is diagnosed as psoriasis.
15. Furthermore the Thymus gland becomes tired and less effective because of all these extra antigens in blood stream it has to fight, and then regulatory T cells don’t clear up unwanted T cells in bloodstream, which then also interact with bodily tissues.
16. Also Candida in the bloodstream overpowers liver and stops it working properly.
17. The body lacks proper nutrients because of (LGS) also weakening immune system.

INTERESTING FACTS
1. Candida in the gut give off toxins such as zymosan. Research conducted at the University of Tennessee in Memphis found that zymosan is found to cause much of the inflammation associated with psoriasis. http://forum.jackkruse.com/showthread.php?2243-candida-and-psoriasis

2. "The fungus Candida albicans is a potent inducer of the Th17 response. Prostaglandin E2 (PGE2) is a strong pro-inflammatory mediator, which has proven to be essential for the Th17 response." - http://intimm.oxfordjournals.org/content/22/11/889.full

3. Intravenous injection of Candida albicans into mice produced elevated serum tumor necrosis factor alpha (TNF-alpha) levels. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC174413/

4. Etanercept (trade name Enbrel) is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor (TNF; a soluble inflammatory cytokine) by acting as a TNF inhibitor http://en.wikipedia.org/wiki/Etanercept

5. ‘Interleukin 17 block’ clinical trial helps clear psoriasis http://www.inspire.com/groups/talk-psoriasis/discussion/week-36-and-cure-is -still-working/?ref=as&asat=52266399

TRY THIS AND SEE IF YOUR PSORIASIS CLEARS
1. Go on a Candida diet (No yeast, sugar or gluten).
2. Take a 50 Billion probiotic
3. Take an anti-fungal such as SPOREgone http://www.amazon.co.uk/SPOREgone-Combination-All---One-Supplement/dp/B001U F2TDK/ref=sr_1_1?ie=UTF8&qid=1351266995&sr=8-1

Have a nice day :)

Edited October 26, 2012 at 11:58 am

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Interestingly, my old PCP told me that P might be a yeast, and had me putting athletes foot cream on my scalp. Of course that didn't work. So I believe your theory.

What are you doing about it? I just read another interesting post about candida and think I need to attack it!

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Mmm, candida albicans could have been -- in your specific case -- a "trigger". It is most certainly NOT the cause. Otherwise, there would be a cure on the market. The immune system reacts in very different ways - as all humans are different - to things which trigger immune system dysfunctions. The immune system uses T4 cells to attack infections and T8 cells to control the attack. In my case, something affected my T8 cells causing uncontrolled immune responses to the slightest perceived infection. <<As an illustration, a lack of or dysfunctional T4 cells are the cause of AIDS.>> Also in my case, I had chronic strep throat as a young child and was pumped full of streptomycin -- issues found present in the medical history of many Ps, PsA and AS patients. In short, the cause of our mutual medical difficulties has not yet been found, but there is medical history noting many possible
"triggers" for the immune dysfunction causing our problems. Good luck with your research. Keep looking and asking questions. (My problems started in late 1976.)

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I am on the Candida diet.

Read book: http://www.amazon.co.uk/Candida-albicans-Could-Yeast-Problem/dp/0722533438/ ref=sr_1_5?ie=UTF8&qid=1349627915&sr=8-5

Cheers :)

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Yes perhaps it is different for different cases. How can you be certain it is not the cause either? Just because Candida is not a known cure on the NHS, it doesn't necessarily mean it is not the cure or a cure in certain cases. Perhaps doctors and NHS are behind in their methods on psoriasis.
I have got a lot of respect for doctors, but I can say from all the creams the doctors have given me so far, nothing has worked as well as what I have found out myself which was to go on the Candida diet. Also you took Streptomycin which is an antibiotic, perhaps that killed off your friendly bacteria. Anyway I'm not saying Candida is the cause or I know what it is and P could be caused by others triggers, but thanks for feedback and good luck. :)

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i agree with others that candida overgrowth could be one of many triggers for psoriasis.
if someone had a poor diet for many years it may have caused lgs (damage to the lining of the small intestine making it porous)
just because someone fixes their diet and any possible candida overgrowth- they still may have leaky gut syndrome.
and if someone manages to cure this leaky gut i think they will still have psoriasis (just not as bad though)
if you suspect this l.g.s. - in addition to your improved diet you can try taking slippery elm powder 30 minutes before your 1st
meal of the day. it is suppose to protect and soothe the small intestine. i tried slippery elm many yrs. ago-i think it was a little helpful. anyways anything you find that helps you and others that is not considered harmful to the body is a big win win.

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The only problem I have with all the "leaky gut is cause" is, I only recently developed LG. After 33 years of suffering plaque psoriasis. I never had an ulcer of any kind, nothing. Until my h.pylori, a direct cause of an antibiotic I was on. But, your information intrigues me, and it certainly will not hurt me to look into it.

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Trigger maybe...cause no.

It's a fairly simple concept.

Gene's.

You either have it or you don't. Nothing you can do to cause it..without the gene..period.

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Even though we may be more susceptible to yeast or fungal infections because of the impaired barrier in places where Psoriasis of the skin affects us most, the condition itself is not 'caused' by a yeast (or fungus for that matter). Long story cut short, unfortunetly for me there have been multiple misdiagnoses by specialists along the way in my journey to a proper diagnosis (I do not have the most common plaque psoriasis type). At one stage I was treated improperlly with anti-fungal/antiyeast topicals (shampoo, creams) and oral treatment for at least three months while tests were being done and then re-checks ordered. Treatment was of absolute no help at all.

Also I tried the low-sugar / low-yeast products / anti-inflammatory food type diet for eight months and that did nothing to help my Psoriasis either unfortunetly.

Shantelle

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I'm about 15 years in, and David's mostly right.

Doctors that tell you it's just 'genes' or your 'immune system' do that to calm your nerves...and feed you their biologics and MTX.

It's much more profitable to just block chemicals like TNF, instead of looking for the cure..

Plenty of discussions in the past over all this.

For people that say staying on a strict diet hasn't helped them...then try a diet full of red meat and/or sugar. Your P will flare tremendously.

The thing is you have to completely go on a diet that is anti-inflammatory and anti-candida. Will it put you in remission ? probably not. But it does help.

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ehhh sorry but dont agree, like most said I believe maybe a trigger but not the cause...people have been suffering from this for many years and there has been so much research done by the best doctors and even they cant fully pinpiont it...I mean absolutely no offense but Its just doubtful to me personally that you yourself could figure out the cause with no real scientific testing or research. I agree with willymon, I believe its most definately linked to genes. Maybe I am just not fully understanding, but if everything your saying were the case wouldnt so many more people suffer from psoriasis? ....just my opinion

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genes...plain and simple...ok not so simple.

Diet can help mitigate triggers and other inflammatory processes but the disease is what it is. Auto-immune diseases have been a tough research arena because of their complexity. when we (royal) distill one's experience to a single cause we lose sight of the bigger picture.

I have had psoriasis in a very big way for my entire adult life (35 years) and I am clear for the FIRST time after starting a biologic 6 weeks ago. LIve well and eat well too!!!

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"Maybe I am just not fully understanding, but if everything your saying were the case wouldnt so many more people suffer from psoriasis? ...." excellent point, llujan

David, there are some seven million psoriasis sufferers in the US, and how many millions of obese, unhealthy, poorly fed folks?

Your argument does not hold water.

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You're clear, that's awesome! Which biologic are you using? Are you on anything else concurrently?

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Hey Fogbee...

It is our old friend Enbrel! The joints are improving but the first big bonus has been the disappearing act the psoriasis has been doing over the last few weeks. Each week a new area goes to 'normal'. Very cool!

I was taking sufazine and mobic but I have dropped the sulfazine because my system wanted to respond unfavorably to it. still do the mobic for evening to help with any overnight pain. That, I suspect is going to be needed less and less the longer I am on Enbrel.

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I remember about 10 years ago I went to see a Chinese man in Kingston about my psoriasis and he said it was fungi on my hands and he gave me a load of herbs to boil up and take but it did not work. But it was interesting what he said I think. I was not getting anywhere using any of the doctors creams and had heard psoriasis needed to be treated internally not externally. My mum is a reflexologist and she recommended me to her friend who works for Allergy UK. Her friend Sue said because psoriasis was on the palms of my hands and in ears and down crack of buttocks, she diagnosed it was yeast in my body. As you know Candida is a yeast. I can honestly say when I go on a strick anti Candida diet to starve the Candida my psoriasis gets better and as soon as I start eating anything that contains yeast, wheat or sugar such as bread, chocolate or milk the psoriasis gets worse. It is known sugar feeds Candida. But yeah perhaps Candida is just one of many triggers of psoriasis, I don't know. At present though going on the Candida diet is the only thing that works for me. Demovate helps but the psoriasis always comes back after 2 weeks, it is like it does not get to the cause.
Since I have veered of the Candida diet last week after over 5 weeks on it my psoriasis has got very bad again. Before is was nearly gone. But the diet is very hard to do for a long time as it is very restrictive and I love sweets lol.
I think what I am going to do next is try a higher strength probiotic such 20 billion, also go on Candida diet again, and look into taking an anti fungal as well. I am presently looking into taking Diflucan. Also Spore Gone is good anti Candida and Biotin is meant to help in the prevention of the Candida overgrowth. I was hoping it was just lack of vitamin D, but taking vit D 4000 iu did not work. Thanks for all your feedback and If anyone has any ideas connected to this it would be great to hear.

Cheers :D

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I agree, starting from the inside out, always had psoriasis spots but not severe, then two years ago, my bowels started doing strange things, I went through tests and came back as Celiac positive, then after a surgery, inflammatory bowel disease was noted, however it hasnt flared for over a year ( touch wood ) yet this year my outside Psoriasis has flared, Im starting to see that Diet does play a big part and slowely adopting the new diet, ( its not easy with a family of 5 ) and low and behold I started on antibiotics for yet another infection on friday and within hours a full blown candida infection started, strange thing was same afternoon my throat and sinus's played up, never experienced something that dramatic, so yesterday stopped antibiotics, on oral candida tablets. Doctors are to quick to hand you antibiotics these days instead of actually investigating things or guiding you in the right direction, most of the advice is off this forum or through my own research into Psoriasis and medical background, I feel alot more confident when I can understand whats happening without stressing.... Wish me luck, if my guttae settles with the diet and after this course of Diflucan then maybe there is a link along the line, especially if it lies dormant in your system ..

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I agree, starting from the inside out, always had psoriasis spots but not severe, then two years ago, my bowels started doing strange things, I went through tests and came back as Celiac positive, then after a surgery, inflammatory bowel disease was noted, however it hasnt flared for over a year ( touch wood ) yet this year my outside Psoriasis has flared, Im starting to see that Diet does play a big part and slowely adopting the new diet, ( its not easy with a family of 5 ) and low and behold I started on antibiotics for yet another infection on friday and within hours a full blown candida infection started, strange thing was same afternoon my throat and sinus's played up, never experienced something that dramatic, so yesterday stopped antibiotics, on oral candida tablets. Doctors are to quick to hand you antibiotics these days instead of actually investigating things or guiding you in the right direction, most of the advice is off this forum or through my own research into Psoriasis and medical background, I feel alot more confident when I can understand whats happening without stressing.... Wish me luck, if my guttae settles with the diet and after this course of Diflucan then maybe there is a link along the line, especially if it lies dormant in your system ..

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Be careful, are you sure you want to take Diflucan, it seems like it has nasty side effects like damaging liver, see http://www.netdoctor.co.uk/skin-and-hair/medicines/diflucan.html

You also have Nysterin, but I don't know if it can be taken internally? Does anyone know?
Also Griseofulvin but that also has side effects and my doctor did not recommend it.
Also Colloidal Silver is an anti fungal, but I did not want to use that.
I would say you need to take high strength probiotic at least 20 billion as well.

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Hi, this is very interesting that you say genes are the cause of psoriasis, you seem pretty sure of this, but what evidence led you to this conclusion?

You say you have taken sufazine and mobic and your psoriasis is going. This is very interesting, do these drugs only temporarily stop the psoriasis or do they permanently get rid of it?

I have a friend who takes an anti cancer drug which has got rid of most of his psoriasis but he has to keep taking it for the rest of his life otherwise the psoriasis comes back.

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