borage seed oil verses fish oil

** Originally posted by light **

Confused once again... I have read that salmon or fish oil were great for omega 3s, but after reading "Inflammation Nation," I find that the author prefers borage seed oil, if taken along
with EPA (eicosapentaenoic acid). Possibly this is for people that have a problem w/ inflammation. While on the subject of oils, I have also always thought that extra olive oil had the highest nutrients, now I see that some have switched to light olive oil, and are using it sparingly why is this?

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** Originally posted by lazza **

Hi. The author doesn't prefer borage oil over fish oil. He says they have a synergistic relationship. So carry on with fish oil (EPA) and optionally take borage oil. But don't take borage oil w/o fish oil as it will make your P worse. I haven't bothered with borage oil but I might consider it down the road.

As for olive oils, I'm clueless. I buy whatever is on sale! And of late I have been using coconut oil instead.


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** Originally posted by DottieD **

Here's what Dr. Chilton says in Win the War Within:

As part of the inflammatory response, certain white cells (T-lymphocytes) are stimulated to produce chemicals that cause our skin cells to multiply too fast. (the familiar arachidonic acid story). These chemicals fall into two general categories: prostaglandins and leukotrienes. It isn't important to remember these names, just that there are two different chemical pathways that lead to two different types of chemicals. So to keep our bodies from over-reacting to an inflammatory stimulus, it is important to try to shut down BOTH of these chemical pathways.

The prostaglandin pathway can be inhibited by taking fish oil or flaxseed oil, which are high in omega-3's. Fish oil is a better source, but some people have trouble taking this, so flaxseed oil is the next best thing. When you take one of these oils, your T-cells have trouble producing the offending prostaglandins.

The leukotriene pathway can be inhibited by taking borage oil, which is high in a particular fatty acid that behaves like an omega-3. (It's called alpha linolenic acid.) So by taking flaxseed or fish oil, AND borage oil, you can slow down both of these parts of your body's overreaction to an inflammatory stimulus. Better coverage. It's perfectly okay to take both borage and fish oil. That's what the book recommends.

Now, what has olive oil got to do with all this? Well, it turns out that our bodies are able to convert some of the fatty acids in cooking oils to arachidonic acid. Sunflower, safflower, soybean, corn, and cottonseed oils are all ones that the body can use this way. So a person with an inflammatory disorder should be helped by staying away from these oils. They are found in margarines, many packaged foods, and fried restaurant foods. Instead, use either canola oil or olive oil. Canola oil is fairly neutral with respect to inflammation. But olive oil contains an omega-9 (oleic acid), which helps to reduce inflammation in the body. So if you use olive oil for cooking you should get further improvement. I don't particularly like the taste of olive oil, so I buy the light tasting olive oil.

Of course, this whole subject is about how we can keep our bodies from overreacting to an inflammatory stimulus. But the ideal solution is to find the source of the inflammation and get rid of that, instead of just tamping down the ability of our bodies to react to it. (That's my current interest.)

Hope this helps,

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** Originally posted by rmh81 **

Has anyone tried evening primose oil as well? I was doing some research on borage oil and came accross this articel which suggests evenning primose Oil in addition to a few others. Interestingly it does not list fish oil which seems to be hands down the most commonly recommended supplement based on the research I have done.

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** Originally posted by lazza **

Has anyone tried evening primose oil as well? I was doing some research on borage oil and came accross this articel which suggests evenning primose Oil in addition to a few others. Interestingly it does not list fish oil which seems to be hands down the most commonly recommended supplement based on the research I have done.

Evening primrose oil provides the same effect as borage oil, as per DottieD's explanation. I seem to recall Pagano recommending evening primrose oil. However Chilton says borage oil has a bit more of the good stuff (GLA) in it. But no, I haven't tried it.


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** Originally posted by light **

Thanks for your words of wisdom and support

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** Originally posted by arabic **

both GLA and omega 3 fatty acids competes with arachidonic acid on lipoxygenase enzyme .GLA and omega 3 produce anti inflamatory products . taking ibubrofen frees more substrate to lipoxygenase so the results will depend on the propotion of omega 3 to omega 6 ,a double edged situation when using brufen

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** Originally posted by OtherThoughts **

I have tried Evening Primrose Oil, Borage Oil and Hemp Seed Oil-(Hemp Seed Oil purportedly contains an ideal balance of fatty acids, including GLA). <a href="http://""">
As Lazza and DottieD have already denoted, it is the GLA content of the Evening Primrose and Borage Oils that lay at the crux of their beneficial potential.

Borage Oil contains more GLA than Evening Primrose Oil does. However, there was, and may still be, some contention that Borage Oil contains deleterious components that Evening Primrose Oil does not.

Your body can make GLA from LA with the help of the Delta-6-Desaturase enzyme. But ingesting preformed GLA, in essence leapfrogs over the Delta-6-Desaturase enzyme hurdle in the Omega-6 pathway.

Ingesting preformed EPA and DHA in fish oils, does essentially the same thing in the Omega-3 pathway, leapfrogging over the Delta-6-Desaturase enzyme, as well as the Delta-5-Desaturase enzyme hurdles. The ALA in Flax oil must pass through these enzymes in order to become anti-inflammatory.

GLA gets elongated via the Elongase enzyme to create DGLA which can then be made into the anti-inflammatory Series 1 Prostaglandins, OR Alternatively, this DGLA might be further desaturated by the Delta-5-Desaturase enzyme to form the highly inflammatory AA. In other words, supplementing with GLA can be anti-inflammatory or pro-inflammatory, or perhaps both. It gets complex.

All fatty acids can compete for the attention of the Desaturase and Elongase enzymes. In addition, nutritional deficiencies can impair the overall functioning of these enzymes.

As an aside - The movie "<a href="http://""">Lorenzo's Oil</a>" was about how Lorenzo's Father, figured out, basically all on his own, that the competitive inhibition of these enzymes, could help his son's disease, while fighting the mainstream medical dogma of the period all along the way.

Information About Lorenzo's Oil-slide show<a href="http://"""></a>

EFA Pathways chart
<a href="http://""">
EFA Pathways article
<a href="http://"""></a>

Sorry for carrying on so long.


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** Originally posted by TaraFIU **

I've been taking primrose oil for over a year. No change in my p. I'm on year 10 of my guttate flare.

I have not tried fish oil or borrage oil.

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** Originally posted by Stouppi **

On the subject of oils,

Apparently (for me), Emu oil, used as a topical, hydrates, and I have finally been rid of the vinyl gloves! . As per inflammation, I have no info.

Does anyone have info on the emu?


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