As I have said in previous posts, I have not yet been diagnosed because no one wants to put me under because my lungs are so bad, but after reading so many posts, we, me and my docs, are pretty sure it's sarc. Anyway, this will be the second time I will be on longer term Prednisone. I was on it for about 6 weeks the first time I quit smoking and I could breath like a normal person. Like an idiot, i started smoking again. I quit again a couple of months later, and have been smoke free for a year. Anyway, I have severe COPD and am always short of breath, even with my 24/7 oxygen. I am taking 40 mg of pred for 5 days then 30 then 20 then 10 for a total of 2 weeks. Has anyone noticed any change at 1 week on this dose? Is a longer term dose going to help the shortness of breath any better than a shorter dose? I am only getting worse and Pulm said I would definetely feel better. I see no hope.