I visited my rheumy today and he has prescribed plaquenil to help treat my scleroderma. I have limited (CREST) scleroderma. My symptoms seem to have worsened over the past couple of months, mainly, extremely fatigued & a lot of joint pain. Also, I am noticing that I become much more short of breath than I ever have before. I have always been very active, could work in my yard all day, mowing grass, running a weedeater, etc. However, this spring, I noticed that I can only work for about 15 minutes before I become so short of breath that I can't even speak. So, I rest for 15 or 20 minutes until my pulse & respirations become normal and work for a while longer. I am waiting for an appointment for my PFT's. I'm just mostly concerned about starting on plaquenil. Has anyone else had any experience with this medication for scleroderma? Good/bad? Just looking for more info. Any help/advise/input is much appreciated.