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Advice needed on Spherocytosis

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Hi,

I was wondering whether anyone could recommend someone or somewhere I can get some decent advice about hereditary spherocytosis in relation to malaria risk.

My boyfriend has the condition and had his spleen removed as a child. He does not take antibiotics and has never had any further problems since (he is now 44!).

We are really hoping to go to Africa on holiday however he has been told that he will be at increased risk of Malaria. Another Doctor has suggested that he might be at a decreased risk of malaria in the same way that people with sickle cell anemia are due to the different shape of the blood. Obvioulsy we don't want to put him under any increased risk but we would like to know exactly what the risks are and we don't seem to get any decent information or consensus from Doctors.

If no one can answer perhaps someone might be able to point me in the direction of someone who can? It would be great to speak to an expert. My partner is also copes much better at high altitudes unlike me and I don't understand why this should be as he is supposed to have less blood and the blood he does have is less efficient at carrying oxygen around the body so I also find this baffling (though less important!).

Many thanks!

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Sickle cell anemia Spherocytosis Malaria Anemia

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The following information from The Centers for Disease Control and Prevention may be helpful:

http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-8/immunocompromised-tra veler.aspx

http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-2/malaria.aspx

Hi, I have always been told by my Dr that malaria tablets do not work on people with spherocytosis and not to go to countries which have it.

Just as a sideline, you should also not eat sushi as the bacteria in the raw fish and the rice is not tolerated by people with out a spleen.

Hope this helps.

The following may be useful to you: "Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen" by the Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force: http://www.bmj.com/cgi/ijlink?linkType=FULL&journalCode=bmj&resid=312/7028/ 430

That is the version from 1996; it was reviewed in 2002 and although the full text of the review is not available online for free, you can see from the abstract at http://www.ncbi.nlm.nih.gov/pubmed/12448592?dopt=Abstract that most of the recommendations remained unchanged, but a few recommendations regarding vaccinations were changed.

Hope that helps.

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