High level of ALP (Alkaline phosphatase)

My son, Gabriel has diagnosed with very high ALP level, 1200 IU/L since discharged from NICU two months ago. Today, he went for a blood test on this particular ALP level and noticed that the level is still high, never reduced. Dr commented to stop medication for a week to observe the level but somehow the level is still high after a-week observation. Dr and we both have no idea on it since the calcium and phosphorus in his blood test are all normal level. We are worrying of issue such as weak bone or liver disorder problem. Would appreciate if someone has this kind of knowledge and experience to guide us or explain on this issue. Thanks.

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No expert here but I will ask... did they also check Vitamin D? My son (who turned out to have a metabolic bone disorder from prematurity) originally was found to only have a slightly low Vit D level. When they increased his dosing THEN his Calcium levels plummeted as his bones were finally able to absorb it. His Alk/Phos level was super elevated because of his bone disease. As he is finally healing is it slowly coming down. We have an Endocrinologist managing this part of his care.

Hope this info helps a bit if it turns out to be bone related... best wishes.

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Thanks for reply. Dr has checked everything but only noticed ALP level elevated but all other remain within standard. I wonder does this high ALP level indicate anything??? liver failure??? bone disorder???

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Son had this. His all phos was over thousand which really bad. Better nutrition, sodium phosphate and vitamin d supplementation was the answer

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Also there is test that can tell what part of the alk phos is from the bone and what part from the liver. My son was followed by endocrine as well for this. Basically though vitamin d was the med that fixed it.

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From whr he can get the vitamin D supplement? We hav given him Appeton, is it. Sufficient? We have no idea on ways to overcome this.....all the while more than thousand but so far no symptom of liver disorder or bone weak problem.

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ergocalciferol (concentrated vit D) I think our endocrine doctor prescribed it. We had to give him 2000 btu every day (400 is normal I think). Elevated Alk phos causes brittle bones.My son had a alk phos number of 1400 at one point. It normalized when he was 4-5 months adjusted. They can do a test that will let you know what percent of alk phos is from the bone and what percent from liver. If it is mostly from bone its better because it is because of prematurity and poor nutrition which can be corrected. Elevated alk phos while of concern is something children grow out of eventually. My son also got sodium phosphate for it when he was in the NICU/Step down unit. (I dont think they prescribe sodium phosphate outside of the hospital.

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Dear Anieta,

Brittle bone???sound so scary!!! But physically we notice the bone development is normal. and Dr also commented his skull is in normal condition and quite tough at adjusted age 2 months. So, how is ur baby after 4-5 months adjusted? Any side-effect of high level ALP??? we have appointment with specialist now!!! Thanks for ur precious points of view.

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Dr mentioned not to worry much though the ALP level has increased to 1400. Given elfacarcidol n sodium phosphate. Hopefully will be reduced to normal level.

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Almost all Lbw preemies have elevated alk phos. My sons doing great. He is completely healthy. Eventually all premise grow out of it. http://en.m.wikipedia.org/wiki/Ergocalciferol this was the bit d prescribed for Abhay. I am sure his level will normalize in a month or two.

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Thanks.Dr is given him only Vitamin D3 (alfacarcidol) but not Ergocalciferol. Is that similar. On top of it, he is given sodium phosphate as well as the phosphate level was low as well.

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