I have resumed chemo and am once again taking neupogen shots for my white blood cells. I have also used neulasta. Both types caused deep aching in my bones - sometimes in my spine and sternum. I guess this is a side effect, although I have talked to some people that did not have the problem. I am a petite- sized 47 year old and don't know if bone size has anything to do with it. Has anyone else had the problem and if so what did you do? Mostly I just take some Advil.