Uterine cancer has spread to my liver

I am starting Chemo tommorrow with Doxil. My doctor has given me 2 choices Taxol weekly or Doxil monthly.
After 6 treatments of Taxol with Carboplatin my tumor marker @ the end of my initial chemo was 11.
Not what I expected when the tumor marker elevated to 62 within 2 mos + now the cancer has moved to my liver. Thats my storey, after reading other postings, my situation is similar to most of the other posters on this board.
I was wondering if anyone out there has had any success with a combination of chemo drugs to treat liver cancer. After reading a bit about Doxil + Taxol , one would think that there would be some newer drugs to treat cancers than these 2 that were invented in the 1950s.

By TeamInspire
Today at 11:55 am
Hello,

I think you meant to post this to the group. To do that, log in and go here:
https://www.inspire.com/groups/ovarian-cancer-national-alliance/start-discu ssion/

Hope this helps!
Heather, TeamInspire

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By JanM



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Your story is much the same as mine. My surgery for removal of ovarian cancer was March 25, 2008. I was on taxol carbo for 6 mo. then had an allergic reaction to carbo so I was left on taxol every week until Dec 2008 when I was given a chemo vacation. In May my cat scan showed that the cancer was now in the liver so I had my first doxil treatment May 8. I have my next treatment June 8. I am optimistic that the doxil will work. I am sorry I do not know about any other treatments. Ellen

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Thanks for the reply Ellen, were you diagnoised with Papillary serous carcinoma? Did your Ca125 count go down after 1 treatment of Doxil? Any side effects? How old are you? I'm 55 + having a hard time coming to terms with this, as I'm sure you are. Did you have a C.T.assisted Biopsy? We live in Massachusetts + although the cancer centers around here are supposed to be cutting edge, it doesn't seem like we have many options.
JanM

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Hi Jan
I was diagnosed with ovarian cancer stage 4. I believe it is adeno carcinoma. I am a senior citizen. I only had one treatment of doxil. Before my next treatment June 8 they will run blood tests. While I was on my chemo vacation my CA125 went from 77 to 107. The lowest it has been was 44. At one time it was over a 1000. I will keep you posted on what happens with me. The only side effects i have had from doxil so far is a small rash on my left foot and a rash on my buttocks. I am treating the rash with creams and trying to expose the areas to the air. I am going to try some baby rash cream

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Ellen, how would you rate your general heath today? + how was your general health before cancer?
I am new to message boards + these are my 1st posts, I am going to check in daily but try not to get obsessed with this. Jan

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Hi Jan.
I am Stage IV OVCA with mets to the liver, not seen at the time of surgery (diagnosed as Stage III at surgery), but discovered on a CT Scan before I began treatment. I signed up for a trial of Carboplatin, Paclitaxel and Bevicizumab. I recieved the standard treatment of Carbo and Taxol every 3 weeks for 6 weeks (last treatment was Dec. 26th) plus either the Bevicizumab (Avastin) or a placebo. My physician, the research nurse and myself believe I received the Bevicizumab rather than the placebo based on my side effects. I continue to receive either the Bevicizumab or a placebo until I have completed 22 treatments, again, I am believed to be getting the actual medication. I have had excellent results. I had 3 tumors on my liver, the largest being 8 cm. and 2 that were 3-4 cm. By the end of my 6th treatment, the 8 cm tumor had shrunk to 2.5 cm and the others to 1.5 cm. My last CT scan the beginning of April the largest tumor was under 1.5cm and the smaller tumors were under 1cm. My Dr. says the Bevicizumab works by cutting off the tumor from the inside, he described it as starving the tumor. I have CT scans every 12 weeks on the study and am hopeful that the next scan continues to show improvement. I have a friend with Breast cancer that has mets to the liver also. She is receiving Avastin along with another medication too.

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Thanks for the reply. I am going to print this + show it to my Doctor. It sounds like you have great hope with this drug. It may be that our cancers are different types but it is exciting on this end to hear that others are on their way to managing cancer.
Thank you
JanM.

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Hi Jan
I feel my health now is better than after surgery and during my taxol carbo treatment because my hemoglobin would go down to 7 before my oncologist would give my any blood. I felt terrible during that time but the taxol carbo did kill tumors that were in my abdomen. Before my surgery I considered myself in good health did 1 hr on the elliptical machine every morning. However ovarian cancer moves so fast that I believe I was in poor health right before the surgery
Ellen

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JanM,
Hope your first Doxil treatment went well today.

I'm on Doxil now and have had 7 treatments for my second recurrence. I had a few tumors, the largest of which was just outside the liver. That caused enough pain for me to need Percoset for a week in order to sleep but after my treatment began, the pain went away and my numbers dropped from 116 to 39 after 2 chemos. My last test showed it at 13. I'm due for another test soon.

Doxil is definitely easier to tolerate than Taxol. You probably will not lose your hair and will have much less trouble with nausea (just a funny taste in the mouth) and fatigue (some, but not bad). The hand/foot syndrome is the biggest problem - and it can be mild or a big problem. It can also not show up for a couple of months so don't assume if you don't get it the first couple of weeks that it won't happen. Mine showed up after 3 months with the worst being after 5 months. Meantime, keep you hands and feet well lubricated with a good cream (the Doxil mfgr. provides Udderly Smooth and that's what I use). I also got Balmex (baby diaper rash cream) on the recommendation of one of the ladies on the site. It's very good if you get any of the red blisters. It's thicker than the Udderly Smooth, so I'd save it for the real trouble spots.

Be sure to avoid any tight clothing, including underwear, socks and shoes. You will get red marks and your skin may show discoloration on any pressure spots. Watch out for red rash spots - they can turn to little blisters and really burn before they dry up. Use the cream as soon as you see them. Stay away from hot showers and hot dish water too.

If you get any mouth sores, you doctor can give an RX for Magic Mouthwash, which numbs them. If they are really bad, ask for an RX for Gelclair Gel packets. I got this about a month ago because of sores on my tongue and it actually helps heal vs. just numbing. It worked right away. I had to take a 2-week chemo break between #6 and #7 to let the side effects calm down. My last treatment was given at a 75% dose, and my next one will also be a lower dose.

All in all, if Doxil works for you, life will be generally easier than with Taxol. Good luck with everything - I hope it works.

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Thanks, favorite aunt, for the feedback. My first treatment went well, no reactions so far. Glad to hear that the doxil seems to be working for you.
Its nice to be connected to a website like this and get to talk to people who are in the same boat.
I am new to this and was wondering if it is possible to read all new postings or just to ones sent to me?
Thanks again.
JanM

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You're most welcome and I'm happy you got through the first treatment with no problem. Chances are you'll be okay with the future infusions too. Just keep a watch for side effects. I forgot to mention I've had very little trouble with low white cell counts while on Doxil, so no Neulasta shots needed. Most importantly - let's hope it works!!

I get an e-mail every morning from Team Inspire telling me of the "new discussions" and "all activity." Do you get that? I assume it is automatic since I never requested it. I can then click on that and catch up with everyone. You should definitely be able to read all postings. There is a link at the top of the page that gives some options - All, Active, Recommended, etc. That should get you what you want.

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Hi Jan
I had my second doxil treatment on Monday June 8. I do not know what my CA125 is but all my other blood work was normal. I still feel strong but am very tired. I have had some rash from the doxil but it has been minimal. However i feel tired all the time. Hope you are doing fine.
Ellen

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My mother was diagnosed with endometrial cancer, uterine papillary serous carcinoma, stage 1C in may 2008. She had a hysterectomy immediately and started chemo in June 2008, by Novemeber 2008 her pathological test looked clean and we thought we had fought it. A few weeks ago, mid june 2009, she had a pain on her side and after a pt scan they found the cancer came back and is in the liver. She started chemo yesterday and it was her first round 2 treatment. Her doctor is top at Mt Sinai (he performed the hysterectomy and the chemo). I am looking for help finding a top specialist who has specifically dealt with uterine papillary serous carcinoma and/or a liver specialist. We live in New york City, so I was hoping to find someone at sloan kettering? thank you in advance for any advise. my warmest regards,

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Hi Jan, we are in New York City, my moms UPSC also spread to the liver. My mother was diagnosed with uterine papillary serous carcinoma, stage 1C in may 2008. She had a hysterectomy immediately and started chemo in June 2008, by Novemeber 2008 her pathological test looked clean and we thought we had fought it. A few weeks ago, mid june 2009, she had a pain on her side and after a pt scan they found the cancer came back and is in the liver. She started chemo yesterday and it was her first round 2 treatment. Her doctor is top at Mt Sinai (he performed the hysterectomy and the chemo). I am looking for help finding a top specialist who has specifically dealt with uterine papillary serous carcinoma and/or a liver specialist. We live in New york City, so I was hoping to find someone at sloan kettering? thank you in advance for any advise. my warmest regards,

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Hi Denise, I am Jans husband Bob responding to your reply.
Can't help you on a top specialist in your area, we are stuck here in western Massacusetts.
Jans [phase 2] chemo recipie was changed from Doxil once a month to Taxol weekly + I feel the Taxol is doing a better job.
Did you see the piece on the PARP . I would like to know if Jan has BRAC1 or BRAC2 ,+ if so this PARP looks promising however a couple of years away [till approval].
I would like to be @ the head of the line instead of the end of the line.
The only way to find out is thru Genetic testing, + they claim before the testing happens you should go thru genetic counciling.
What chemo are they treating your Mom with this round ?
Jan became run down + recieved 2 units of blood last week, she is still so tired she doesn't even leave the couch . except to eat + go to the bathroom.
Let us know if by you hear of anything new, this form of cancer is different from most.
How old is your mother?
Best of luck. Bob + JanM

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