Hi everyone,
To recap, my mother was diagnosed with stage IIIc ovarian cancer in February 2009. She went through 6 cycles of chemo (5 with IP/IV cisplatin / taxol, 1 with IV carbo/taxol). Her scan in July showed NED and her CA-125 went from 20 (at it's highest) to 4 (clearly it's not that great of a marker for her).
Now we are looking at trials to help her stay in remission. We initially considered the Xyotax study, but she was not a candidate because of her neuropathy. There is a study opening up at several centers around the country involving pazopanib (once a month for 12 months as maintenance). It's similar drug to avastin. It was recently approved for renal cancer I think.
Has anyone had any experience with pazopanib? I don't think many people in the US will because the trial is just opening, but if there is anyone in the UK / Europe or Australia who has had experience with this drug, please share.
Many thanks and God Bless,
Anne
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pazopanib trial
- By agg22
- Posted August 29, 2009 at 9:44 pm · 5 replies
- In Clinical trials
- Shared with the public
Explore topics in this discussion:
Cancer Taxol Surgery Chemotherapy Renal cancer Confusion Avastin Ovarian cancer
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- By Shamrock2009
- Posted August 30, 2009 at 1:21 pm
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Is this the study?
http://clinicaltrials.gov/ct2/show/study/NCT00866697?term=pazopanib&cond=%2 2Ovarian+Cancer%22&rank=2&show_locs=Y#locn
I don't see that this study is opened at any US sites. Eligibility requires start enrollment/randomization with in 12 weeks of completing chemotherapy so the US site would have to open soon.
Treatment is Pazopanib 800 mg daily or Placebo for 52 weeks (12 months) not once a month.
- By agg22
- Posted August 30, 2009 at 4:02 pm
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Hi,
yes this is the study. Sorry for the confusion. It's set to open at UCSF sometime within the next month. They said that if it opens by the second week of September my mom would be eligible. It is once a day oral treatment - the checkups were once a month - I misspoke.
Has anyone else heard of this? It's going to open at several sites around the country, but UCSF is planned to be the first one. We met with the researchers and they said that my mom is eligible, but they are just waiting for the final paperwork.
Thanks,
Anne
- By Shamrock2009
- Posted August 30, 2009 at 4:47 pm
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Good luck.
It sounds like an interesting drug.
- By walkabout
- Posted September 11, 2009 at 4:34 am
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I'm in Australia and started on this pazopanib study, just three days ago. Of course I don't know whether I'm taking pazopanib or the placebo.
So far I have no ill-effects, except for a slight nausea mid-afternoon each day (I'm taking the tablets at about 6am each morning), which could indicate that I'm taking pazopanib itself, or perhaps indicates that I'm pretty suggestible!
My monitoring appointments are every 3 weeks for the first few months, dropping to every six weeks later in the year for which I'll take the tablets. I'll be having blood tests (CA125 of course, but also liver function etc.) and an ECG on the same schedule. I've also got a daily "diary" in which I have to record the taking of the trial tablets, plus any other drugs I take, as well as whether I experience any of a number of possible side-effects.
Apart from the regular appointments, the only thing that interferes with my normal routine so far is that the two tablets have to be taken at least two hours after food and at least one hour before food, and at approximately the same time each day. I've chosen to take them as soon as I wake up, then doze for an hour or so before getting up and having breakfast.
I was diagnosed and had surgery in late March this year, followed by 6 cycles of carbo/taxol, so the timing of recruitment in Australia was just right for me. I'm told I'm the fourth person in Australia, and the first in the state of Queensland to go into the study.
This is my first-ever post to a discussion like this, so I hope I've not broken any rules, and that the information is useful.
Best wishes to you all.
- By agg22
- Posted September 11, 2009 at 5:11 pm
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Thank you this is so helpful! i'll forward it to my mom. We have decided to go on the study, but now it's taking a few days for all the paperwork to come together. I'm hoping that everything will be finalized within my mom's 12 week window.
Best wishes to you as well!
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