ONT-10

I start the clinical trial for ONT-10 on Monday. I'm so excited! I was diagnosed May 23, 2012. Late stage -- I had 3 rounds of Carbo & weekly Taxol, then surgery, followed by 3 more rounds Carbo & weekly Taxol, then two single treatments of Carbo/Taxol. I still have two small spots on my lungs, a nodule next to my liver, and a questionable lymph node, but all of this is stable. On Monday, I go for the screening, Tuesday I'll get a single dose of cyclophosphamide, and next Friday I get the first dose of the vaccine.

Has anyone been on this trial? Any experience with Cyclophosphamide?

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I am in another vaccine trial, GOG 255, just wanted to wish you luck!

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I took cyclophosphamide as one of three drugs when I had high dose chemo in 2003. Other than killing all my bone marrow, which was the intent of course, the only major side effect was nausea. I had a five year remission after the high dose chemo and stem cell transplant. I have low grade chemo which is very resistant to chemo, in my case. I have a friend who was treated with the drug over 30 years ago and she is still NED.
I looked for your trial and found one in Dallas for solid tumors that mentions only ONT-10 and not the cyclophosphamide. It's NCT01556789, Phase 1 study of ONT-10 in Patients With Solid Tumors. Is this your trial? It's the only one that came up in a search for ONT-10. I must be missing something because I doubt they would be giving you an additional chemo not listed in the protocol.
I am looking for a treatment now and am interested in the vaccine trials.
Thanks for any info and good luck with your trial!
Janet

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TealJanet,
Yes, that's the trial I'm starting. The cyclophosphamide is only given one time, three days before the start of the vaccine, so maybe that's why it's not listed?

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Love those ladies on the clinical trials! I'm also looking for something in case my stable disease decides to get moving again. I have high grade serous papillary and all the tumors are tiny so no solid tumors for me. My Dr also said no phase 1 trials for me also.

Prayers for a good response,

Marty

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Have the announce results for this trial yet?

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I contacted the trial coordinator on May 8 and she told me there was a long waiting list but she would put my name on the list.
I hope it proves effective. Keep us posted.

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Congrats on getting in the trial. Please keep us posted. Always love hearing of new drugs and treatments from the people on them:).

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I got the 4th dose of the ONT-10 yesterday. There has been no change in my CA-125 (14.9 to 16.8), but they say it's too early to expect that. I have a CT scan on Friday, May 31. I haven't had any severe side effects from the ONT-10. A little more tired than normal, but it hasn't stopped me from doing anything I really want to do. The only thing I seem to be too tired to do is clean house!

@Mourton -- when I first signed up, they told me there was a six month waiting list, but I got in after only 2 months when they were able to open several more spots. So hang in there and please let me know when you get in!

Praying it's working!!!

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Update - The CT scan didn't show any "significant" changes. There were some areas that appeared smaller or less conspicuous, and a couple of spots that appeared new or more conspicuous, but overall, nothing drastic. The good news is that I will continue on the vaccine every six weeks for the next year. My CA-125 will be tested every six weeks and I will have a CT-scan every 3 months.


PS: Ned told me there was someone new on the trial who has been reading my comments on here. Please identify yourself and share how the trial goes for you!

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