LipoDox

Is anyone familiar with the chemo called LipoDox?
It looks like this is my next chemo?

Edited April 3, 2012 at 5:13 am

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I am on carbo/lipodox. Had 1 treatment already with minimal side effects. Won't lose my hair. No neuropathy or bone pain for me so far. Make sure you get a MUGA Scan before you start. This drug has a low risk of heart failure and the MUGA Scan will give them a baseline of the blood flow into your heart. My first line of chemo was brutual on me. I still had residual low level fatigue from the first line of chemo even after 2 years. One dose of Lipodox and that wiped all that away. I haven't had this much energy in about 4 years. I think you'll do fine on this chemo.

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Lipodox is the new name for Doxil. Just back on the scene again after halted production of Doxil. Not sure if side effects will be the same as Doxil but they say the active ingrediant is the same. I was on Doxil. There is the hand foot syndrome to be careful of, can leave heart damage, etc. My hair did thin a lot. Maybe someone will chime in if side effects are same.

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I have had one treatment of Lipodox. I had premeds of Kitral, and small dose of decadron. The infusion was very very slow since I had a burning sensation in my mouth, but did not get any hand foot syndrome. I was told to put lotion like eucerin on hands and feet daily which I do every day since infusion. I had no nausea, but was tired, weak for several days. I had the feeling as if I took Neulasta shot which I didn't. It hasn't effected my blood counts much. I go for second treatment next week. My ca125 did not go down, but I am told by my doctors that it takes two cycles.

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Yes, I did have to have a heart scan before I began treatment.

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How and from whom are you getting the Lipodox? Our Ongologists say that a multi millionaire can't get any and the Big hospital can't get any and it is not legal to bring it into USA. What is going on here?

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Lipodox is very much legal. The FDA approved Lipodox for a replacement of Doxil because Doxil production was halted for various reasons. You need to check with your Oncologist again. I am still receiving what is remaining of the Doxil because I was on the physician list to receive Doxil. The following was found on a web site: Patients cheer as FDA eases shortages of 2 crucial cancer drugsBy JoNel Aleccia
Ovarian cancer patients whose treatment was interrupted or even stopped entirely because they couldn’t get supplies of the critical chemotherapy drug Doxil applauded news early Tuesday that federal health officials have found a solution to the shortage.
Following story found on web site:

Food and Drug Administration officials said they have arranged to import temporarily a replacement drug called Lipodox from an Indian manufacturer, Sun Pharma Global.

"That's great. I'm very glad," said Diane Nathanson, 62, of Richmond, Va., who was diagnosed with ovarian cancer in 2006.

“It’s been such a struggle," she said. "Even when I got it, it’s like, ‘Yeah, I got it, but there’s thousands more who didn’t.’”

Advertise | AdChoicesNathanson, a retired chef and librarian, had her Doxil infusions postponed twice during recent treatments. On Monday, the drug was available for her, but she learned it was no longer working; a marker for her tumor progression had risen.

“Who knows if it would have worked if I’d had the drug all along?” Nathanson said.

Availability of the new drug is expected to end the Doxil crisis, FDA Commissioner Margaret Hamburg said in a statement released Tuesday.

"Through the collaborative work of FDA, industry and other stakeholders, patients and families waiting for these products or anxious about their availability should now be able to get the medications they need," Hamburg said.

This is the second significant drug shortage resolution that the FDA has announced in a week. Last week, officials said they had eased a dire shortage of methotrexate, a chemotherapy drug used to treat childhood leukemia. Ohio-based Bedford Laboratories agreed to release limited supplies of the drug produced before affiliated Ben Venue Laboratories shut down because of manufacturing problems last fall.

On Tuesday, the FDA also confirmed the agency has granted approval to APP Pharmaceuticals to produce a preservative-free version of the generic drug, the kind most needed to treat acute lymphoblastic leukemia, or A.L.L.

In addition, the agency said it has helped manufacturer Hospira to expedite release of an additional 31,000 vials of preservative-free methotrexate, enough for more than one month's worth of demand. FDA officials are also working with other manufacturers to increase production.

That should help ease the worries of Sara Stuckey of Lincoln, Ill., who was told there was only a week's worth of methotrexate left to treat her 6-year-old son, Nate, who was diagnosed in 2009 with A.L.L.

"It's hard enough to hear your child has cancer, but to hear that the treatment that is successfully working is no longer available is devastating," said Stuckey, who addressed an FDA briefing Tuesday. "My husband I pray that the recommended drug to fight his cancer will be available."

The Doxil move resolves a shortage that has made the drug virtually unavailable since June because of manufacturing problems. The drug is also used to treat multiple myeloma and AIDS-related Kaposi sarcoma.

FDA's Lipodox deal is a temporary, limited arrangement with Sun Pharma Global FZE and its distributor, Caraco Pharmaceutical Laboratories Ltd. The agency has authority to import foreign drugs on a limited basis in rare cases of a shortage of critical drugs.

FDA officials said that they had previously inspected the Indian firm, which already exports the drug to other companies.


Patients who need Doxil have been placed on waiting lists, had treatments deferred or have been forced to turn to other, perhaps less effective, regimens as a result of the short supply. Restoring access could be life-saving, said Maggie Heim, 58, of Hermosa Beach, Calif., who posted word of the deal on her Facebook page late Monday.

“Oh, that’s so excellent,” said Heim, a lawyer who has collected more than 800 signatures demanding that the drug’s supplier, Janssen Products LP, restore the scarce medication. “So I can throw my petition away, I hope?”

Advertise | AdChoicesSun Pharmaceuticals Industries Ltd. is based in Mumbai, India, and has a rapidly growing share of the global drug market, according to the firm’s website. Lipodox is a version of doxorubicin hydrochloride liposome injection, which can be used alone or in combination with other drugs to treat cancer.

Doxil and methotrexate were among 287 drugs in shortage in the United States, according to the University of Utah’s Drug Information Service, which has been tracking the problem.

Shortages have been mounting in recent years, up from about 74 in 2005, according to the Utah program.

The escalating problem has caught the attention of Congress, but bills requiring prompt notification of shortages are languishing., advocates say. Last October, President Barack Obama issued an executive order led to a rule that now requires drug makers to report promptly shortages of critical drugs. On Tuesday, the FDA also issued draft guidance to drugmakers on detailed requirements for both voluntary and mandatory notification of issues that could disrupt the drug supply.

Since fall, the FDA has used new information to intervene early with manufacturers to avert shortages of drugs. In 2011, the agency’s efforts avoided 195 shortages, said Erin Fox, who runs the University of Utah drug tracking program. Before the methotrexate and Doxil successes, the FDA already had avoided 18 shortages by the end of January this year.

For patients like Heim, who was diagnosed with stage 3 ovarian cancer in December 2009, the FDA’s effort to replace Doxil is reassuring after months of inaction.

“I’m not sure they do have the tools they need, but someone’s being proactive,” she said. “Having Doxil in the arsenal again is good.”

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I am treated at UCLA! Lipodox is legal to bring in the US per the FDA.

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I have had one dose of Lipodox with minimal side effects. The worst s/e has been mouth sores which were extremely painful. My blood counts have held up much better than they did with Gemzar. Let's hope my CA125 starts going down. will get another dose 4/17. I did keep ice on my hands & feet during the infusion and sipped ice chips. Next time I will continue the ice chips for about a week hoping to prevent the mouth sores. I am from a small town in Eastern NC and my onc. Is in private practice.

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Wow! Congratulations to those of you who are able to restart dioxil. I'm hoping to get on eventually; I was told there were lots of people on the waiting list. Mysterious how these things work. I'm on avastin and topotecan now with declining ca125...at least last month. Good luck to all of you.

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Thanks for all the input on availability of Lipodox. I will forward to our oncologists.

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Here's my post on Lipodox. I understand from another sister here that her insurance is paying. http://helpkeepasisteralive.blogspot.com/2012/04/sorry-ive-been-gone-for-wh ile-still.html

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I have read up on the issues concerning Doxil and Lipodox and concluded that transparency, truth and honesty are missing. I signed the petition and am sorry that so much confusion exists and that patients are not getting the medicines to save and/or extend their lives.

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My goofy brain thought Lipodox was short for some kind of liposuction.

In the back of what is left of my head I wonder if liposuction would help prevent recurrences, minimize the fat....ya know.

Anyway, I am very relieved that those of you who have needed Doxil are now able to get a similar drug soon. Blessings to all.

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