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Hi Ladies,
Well, I've read about Doxil side effects...and I am having Doxil side effects. What I want to know is this:
If you were on Doxil, are you in remission now? How long have you been in remission? I had my first recurrence in February. I had carbo/gemzar and now I've just had my third round of Doxil maintenance. Anyone out there have good news to tell me about Doxil?
Cancer Taxol Surgery Arthritis Radiation therapy Avastin Blisters Ovarian cancer Cytoxan Testicular cancer Pain Rheumatoid arthritis Carboplatin Lung cancer
Dear Pshan,
I will get my third infusion of Doxil this month (following three infusions of taxol/carboplatinum). As for Doxil side effects - mine have been very minimal. I will get a CT (and possibly a PET) scan after the third treatment to see if I am in remission. Will let you. Good luck to you.
thanks Paula,
you are being treated for a recurrence as well?
peggy
I was on Doxi for a recurrence for 8 months earlier this year. It worked for the first 6 months and then we came to a standstill and my number went up a little and we couldn't get it down.
Side effects with Doxil are dicey. Some don't show up until after a few months. I did pretty good in the beginning and then after about 4 months I had terrible red/burned heels, despite me using cream all day every day. My doctor had to give me a 2-week chemo break to let it calm down. There were some mouth issues too, but we coped with that. If it kept working, I would have stayed on it, but no luck.
I then tried Topotecan for 2 months (nothing) and am now on Avastin & Cytoxan (pill) and still trying to get back into remission since last Nov.! I wish you the best of luck. Everyone is different and you could be the success story.
My wife's Doc will keep her on Doxil indefinitely, 2-3 years or more. Diane is being treated for platinum resistant cancer and will need to be controlled forever. She is 7 cycles in with bad skin for 4 cycles, mouth sores and the lot. Now, not too bad. He said he will change to Avastin if something changes.
Hi,
I am platinum resistant and have had two treatments. Too early to say anything other than my CA came down but not much.
Would love to hear about sucesses too.
GEPI
I am 14 months in remission from my 2nd recurrence.\
I did Doxil only and I am stage IIIC
September was my 5 year cancerversary!
I was on carboplatin and taxol for 8 cycles and had to stop. I was switched to Doxill. It didn't help my particular case, and I found the side effects to be very uncomfortable. I had blisters on my hands and feet and they felt sunburned most of the time. I am on Avastin and Cytoxan not and am having better results.
I just found out about a not-perfect PET scan. The carbo still worked for me, but it came back 5 month later. The carbo almost gave me an ulcer...don't think that I can do this at this time.
So my doctor, when she called mentioned Doxil. I just don't know if I can take my skin blistering, etc...is it bad? Is there a chance that you can quit the Doxil and have a nice remission period, or does it just come back as soon as you quit?
Sorry for the hard questions...I am just having a hard time here the past couple of days...
I just found out about a not-perfect PET scan. The carbo still worked for me, but it came back 5 month later. The carbo almost gave me an ulcer...don't think that I can do this at this time.
So my doctor, when she called mentioned Doxil. I just don't know if I can take my skin blistering, etc...is it bad? Is there a chance that you can quit the Doxil and have a nice remission period, or does it just come back as soon as you quit?
Sorry for the hard questions...I am just having a hard time here the past couple of days...
I was on carbo and doxil for a first recurrence and completed treatment in June this year. My numbers went down fromn nearly 200 to ten. I am now maintained on a mild treatment of treosulphan and my ca125 is 9.
Zoe
To TvlBeach: How long did you do the Doxil? Can you elaborate? Thanks!
I started Doxil Mar 08 and Finished Aug. 08. I had a bad reaction and had the blisters, but my Dr's lowered the dose and I was fine after that. Side effects were swelling in the legs and the blisters, but once they figured it out I was fine. Email me if you want TvlBeach@Yahoo.com
I just had my 4th Doxil treatment on Friday. Here is how things have gone for me. After no results from the terrible Taxotere/Avastin, I started on Doxil. The first chemo was awful, but it was because the chemo nurse gave it to me to fast. I had face swelling, flushing, chest pains, headache, nausea and bathroom issues, all at one time. But, remember the nurse did it in 60 min. not the 90 min it was suppose to be done in. I am using ice gloves on my hands and feet, each and every time. I do have nausea, flushing and just sick for 3 days afterwards. I usually get right on time, two weeks after chemo, terrible mouth sores which prevent me from eating. Along with a very hard time swallowing food. I just found out on Friday from my doctor she has another patient that is having this same problem with swallowing. Hummmm. Anyway, I still have skin peeling of my heels in sheets. Painful to walk on the heels, walk like a chicken at times, funny looking too. I have gotten skin rash under my arms pretty bad too, along with discoloration, which is not important to me. I have it everywhere that is a hot spot, so to speak. I think that will go away. I do have low white counts as well as the red ones. However, I don't eat and have lost 30 lbs so far. My CA125 has gone up, but the drug company said it would some.
Now good news for me, the CT Scan came back and said, there is a decrease in number and size of tumors. But I still have stranding going on. I don't like that part but I'll take anything after 36 months on 9 different chemo chemicals and 5 times losing my hair. I am scheduled for 2 more Doxil treatments, then CT Scan again. Who knows: I have a rare form of OVC and they don't know what to do for me. But, I'm still here fighting.
Yes, I am being treated for a recurrence.
I got 6 cycles of Doxyl & got ALL the side effects , which I wouldn't have minded BUT I GREW CANCER IN A PORTION OF MY BOWEL called the cecum . I was on this site daily and I noticed very few people had success with Doxil. I have no faith in Doxil, same with Topitecan (sp) JUST MY OPINION
Thanks for your honest discription of your experience. How are you doing now? what drugs have helped you?
Well what happened was I finished the doxil on 6-19-09 I think it was , had a ct on 7-2-09 which showed the small mass in my cecum. Then on 7-28-09 got real sick, pain and vomiting , got hospitalized had another ct which showed the mass was growing and I had a partial bowel obstruction.My surgen called and made an"urgent appointment"with my oncologist. I assumed she was on the same page with my surgen , she suggested I start on TOPETECAN (sp) , so I said sure what ever you say. I got 1 dose that day and then I went home and read about it and I went on this site. I got the feeling it is just like doxil. One week later I went back to a covering oncologist , told him my fears & he AGREED WITH ME .I switched dr's, I am now on gemzar and cisplatin .I had responded to platinum based very well the first time in 03-08 to 07-08,which is something to keep in mind . So now I have had 6 doses feel pretty good can work full time . All my pelvic bowel obst like pain is gone . Not sure how many more doses I will get , but so far so good. I was diagnosed in 02-08 with 3c. Hope this helps , I hate to see anyone go through all the side effects if it doesn't work.
I am now on chemo for the 4th time. I had Doxil the second time. Doxil kept me off chemo for 8 months, longer than anything else has. I'm not sure that qualifies as "successful," but it's the best I've seen yet.
Joan
Hi Moey,
Glad you're on cisplatin. I know several women...long term survivors .... who have cisplatin in common.
I was on Doxil for 11 months and had the usual side effects, but did not experience the blistering. It brought my CA125 down from 262 to 96, but could not maintain it. Had exploratory surgery with the removal of infected lymph nodes, followed by six weeks of radiation therapy, and then onto Topotecan chemo treatments for three months, which did nothing for me.
However, after my three months, I was having a hard time breathing and a very rapid heart rate. Had a eco-cardiogram and there was a lot of fluid build up around my heart, resulting in me being hospitalized and having a pericardial window. Upon research, we found this side effect listed for Doxil, so this is something you need to be aware of.
Now my oncologist wants to put me on a combination of Ifex & VP16 (Isofamide & Etoposide) and have to discuss why because in checking these have been used for lung cancer and testicular cancer and the side affects are horrible. I have already gone through four combinations of chemo and would rather try the Avastin. Now I'm being scoped tomorrow for a blocked common bile duct and they said they see a spot on my liver and some swollen lymph nodes in my chest.
Has anyone had or heard of Ifex & VP16?
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