I started carboplatin for 1st recurrence (local)yesterday and severe allergy reaction appeared soon after infusion.
The infusion was supposed last 30min and nurse said because I do only carboplatin so don’t need premedication(benadryl and steroid) The allergies was started with tingling throat, pressure in bladder, face got red and sworn with ear drums banging, constant coughing, squeezing pain of heart, shortness of breath, blood pressure got lowered (before treatment was 141/72 to 102/47) the nurse stopped the infusion immediately and benadryl shot was given and I was stabilized after that.
In 2010 September, I started 6 round carboplatin/taxol with premedication and well tolerated. Last August had second debulking surgery, with Hipec treatment which used high dose of heated carboplatin and had no severe allergic reactions. Why this time severe allegic reaction?
I wondered that if premedication was used it could had been prevented.what will be the next choice of chemo drug, my doctor will try again platin drug with caution?
According to CARIS my cell molecule test cisplatine, carboplatin is best potential benefit drugs for me along with docetaxel, pacitaxel and tamoxifen. Some of lack of benefit drugs are topoteacan and gemzer. That is why my doctor wanted to use single drug carboplatin instead of carbo/gemzer combination. However my surgeon said studies showed the combination has good synergy effect.
I am worried and confused. Anybody have same experience or any knowledge about this?
Thank you very much, Yun
Edited November 1, 2012 at 10:22 am