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Is gene transplant the cure?

Jill_Nic
0 Recommendations

Im just wondering what everyone thinks about this. Would a gene transplant cure NF? It has been done.

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Cancer Pregnancy Stress

18 replies

sweetiecat

I don't know. My brain can't think that hard. lol

pops

I doubt it very much nf is genetic and to have it removed you would have to go all the way back and I believe it would be very difficult if not at all possible...

tresham

NF is not genetic!!?

Raulargentina

NF is purely genetic, it`s a problem in number 17 one, there aren`t any news about any cure, I met genetist Dr Susan Huson of Manchester on may in Buenos Aires and we asked questions about the issue, no news. I´m sorry about my answer, I´m looking for the same good answer as you, I´m very worry about my son.

DonnaB78

Not genetic for all!! my dad was first our family to get it!! he passed it on to me but no one passsed it on to him!!!!!!!!!

kiddo822

NF is genetic since its on the genes. It can be a spontaneous mutation in a gene during fetal development, me and Donna's dad for example. But now that I have NF, i have a 50% chance of passing it on to a child since my husband isn't a carrier. In terms of the original question. I think the future is unknown. With all the stem-cell research going on, I think it may be possible, but its still a long ways off. I think you can test a baby for it during pregnancy, but still no cure.

Robtygart

This is what I understand NF as

NF has to do with a gene, this gene in people with out NF will turn on and off, which grows a protection around nerves. With us the NF gene is always on.

I don't know what is possible. All I know is there has been some shows on PBS about gene mapping, and from what I have seen they are making some breakthroughs, as for NF I don't know.

Jill_Nic

NF is genetic, but as kiddo822 said it can be a spontaneous mutation. I am the only one in my family with it. My parents do not have it or my brother either. I really do think that they can find a cure.I pray every day that it will be in atleast my childrens lifetime. I have 2 kids who i have passed it to. Well one for sure. My youngest 8 months only has a couple of very light CALS.

DigitalBuddha

I am the only one in my family with it.

Raulargentina

Genetic don´t mean transfer of genes, in our case it means changes in a gene. In this case is a problem in gene nº17, could be tranfered of by gene spontaneous mutation

Raulargentina

sorry transfer OR by gene spontaneous mutation

Robtygart

Ok I think some of us are or I am talking about a differant thing.

We all have this signal in our head that I have been calling a gene that is telling our bodys to grow the NF tumor,

As I said in my last post

NF has to do with a gene, this gene in people with out NF will turn on and off, which grows a protection around nerves. With us the NF gene is always on.

CindyLouWho

The NF gene on chromosome 17 codes for a certain protein called neurofibromin. Neurofibromin regulates certain pathways including RAS and cAMP. These pathways cause cancer and tumors. Neurofibromin is the "molecular brake" that keeps RAS in check thereby preventing tumors. When there is a mutation on the NF gene then neurofibromin is lost. When neurofibromin is lost then the pathways become deregulated and the ability to suppress tumors is also lost. If a moleculor switch can be found to turn off or inhibit the RAS pathway, something that can approximate the role of neurofibromin, then theoretically tumors can be kept in check. This is why most of the current drug trials and research are directed at those certain pathways.

Hope that makes sense.
Cindy

NF238801

There is no cure for me. How do you cure a bowed leg that is longer than your other leg. I just hope that if I have children, it won't be passed on to them.

NF238801

O yeah I am the only person with NF in my family. No siblings or parents have had it on either side of the family.

tresham

Pops has never come back to say why he thinks NF is not genetic.
I have NF because of a mutated gene. It's genetic!

kisses4you1969

Because of the chances of passing on NF1, I chose not to have children. It has caused a great deal of stress. I didnt want that for any child I have. I believe I have missed out the great experience of being a mother, but because of the way the world is today, everything is based on what you look like.

lynnea

To CindyLouWho please... Where did you find this type of information? I need my info in laymens terms as well. I have a nerve sheath tumor with a mix of cd3 positive t-cells and cd20 positive B cells. I like the way you presented your facts here and I need to find something to read about my undiagnosed diagnosis's biopsy that I can understand. I google but it's all in medical terms. I'd appreciate any input.
Thank you. Lynnet20022002@yahoo.com

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