Nephrotic syndrome is a condition marked by these symptoms: 1. very high levels of protein in the urine (proteinuria), 2. low levels of protein in the blood, 3. swelling, especially around the eyes, feet, and hands, and 4. high cholesterol.
The nephrotic syndrome is a set of symptoms, not a disease in itself. It can occur with many diseases, so prevention relies on controlling the diseases that cause it, such as FSGS. Treatment of the nephrotic syndrome focuses on identifying and treating the underlying cause, if possible, and reducing high cholesterol, blood pressure, and protein in the urine through diet, medication, or both.
The nephrotic syndrome may go away once the underlying cause, if known, is treated. If the cause is not known, the condition is referred to as idiopathic Nephrotic Syndrome. When these cases do not respond to treatment, the kidneys may gradually lose their ability to filter wastes and excess water from the blood. The final outcome may be End-Stage Renal Disease (ESRD).
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http://www.nephcure.org/Info_aboutneph.html
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