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Update on Strontium Malonate

BoneLady
0 Recommendations

Osteologix, Inc. has received a key U.S. Patent Allowance for its osteoporosis drug, NB S101 (strontium malonate). This brings the company closer to its goal of manufacturing and marketing a prescription strontium drug in the U.S.

The Notice of Allowance from the U.S. Patent and Trademark Office is for U.S. Patent Application Number 11/269,289 titled "Water-Soluble Strontium Salts for Use in Treatment of Cartilage and/or Bone Conditions." It allows claims covering the treatment of osteoporosis and related bone conditions using NB S101 (strontium malonate). The patent will most likely issue in the second half of 2009 and expire in 2024.

Explore topics in this discussion:

Boniva Nexium GERD Fractures Fosamax Reclast Pain Heartburn Osteoporosis Stress fractures Stress

12 replies

zeta

Thanks BoneLady for updating us on this important topic. I also visit your website to see what's new, and it's always a real treat, chalk full of great information.

zeta

zeta

Hi BoneLady,

Do you know how I can find out what the ingredients are in Strontium Malonate? For example, do you happen to know if it contains aspartame as does Strontium Ranelate.

I realize it's not ready for marketing yet, but I wonder what is being used ingredient wise in their trials. Perhaps this information has already beeen posted to this group, and my apologies if I missed it. There's so much information to keep up with!

Also, it crosses my mind that they likely would not divulge all the ingredients?

Thanks--zeta

drizzit

Well it you look at the study they are saying this strontium salt, Malaonate, is more effective than the strontium salt in use in europe. It appears that the salt may make a difference and Citrate may or may not be as effective. I think the jury is still out.

Bonelady I see from your blog you were due for a dexa scan. How did that go?

raindancer

I will be having my annual checkup next month..no Dexa as I had one last August and it was BAD news! My Dr is quite insistant on Reclast and I am equally resistant to it..I have had 2 bad autoimmune disorders and spent over 10 years of my life in total misery and pain, every day was just something to struggle through. I am somewhat improved now and and hope to stay that way.

I plan to talk to Dr about strontium as a possible help altho' I am not sure she is willing to look into it, most of her patients just take the Reclast or Boniva or Fosamax and shut up.

Thanks for the good links and info on this page..I am doing a lot of research on the strontium option [well my option, I don't know about Dr...lol...]
Part of the problem will be that no one there will know how to recalibrate the dexa machine to get a correct reading with the strontium.

Right now, it is about the only thing lacking in a long list of helpful additions..I am mighty sick of all those extra pills because I have had GERD so long that I have problems swallowing pills, have gone to Liquid Calcium with Magnesium and Vit D in addition to more Vit D, Vit K, horsetail [silicon], boron, plus mutivit and tumeric [that for inflammation.]

I need to be more diligent with my strength training and balance exercises and my prune intake..I thought I really liked them..this last bag [a different brand ] is pretty yucky.

The only thing I worry about with the strontium is upset stomach which I have almost all of the time anyway. I took myself off most of my Nexium and so far have done pretty well for the last month..may have to go back on it part time but I know that stomachs need stomach acid which they don't have if one is on Nexium..I am using vinegar to boost stomach acid and sleeping only on my left side which seems to help..my stomach hurts less now than it did on Nexium. Does anyone have a favorite over the counter strontium?

BoneLady

drizzit,

I posted my recent DEXA scores on my blog yesterday. They were significantly improved and I plan to continue with strontium citrate. My family doctor is not going to object as long as the scores keep going up.

BoneLady

BoneLady

Osteoporosis_D,

Thank you for the link, which provides an excellent summary of strontium, including how to take it. Yes, I believe that strontium supplements can be as beneficial as strontium drugs, provided that the supplements contain strontium in the optimal dose. The problem with supplements is that they are not as well regulated as drugs and sometimes contain less (or more) of the supplement than is shown on the labels. Also, patients in the U.S., where there is currently no approved strontium drugs for osteoporosis, do not get their DEXA scans corrected by radiologists, as they do in countries where strontium ranelate is available.

I just posted the results of my latest DEXA scan after treatment with strontium citrate. This is on my blog. I am not allowed to post the URL on this site, but if you visit my NOF profile, you can follow the link to my blog at the bottom right of the page.

BoneLady

BoneLady

Hi! raindancer,

It sounds like you have found a good combination of vitamins and minerals, including liquid calcium with magnesium and vitamin D.

One problem with strontium citrate is that it is a supplement. Therefore, the radiologists in the U.S. will not correct the DEXA scan results for patients taking it. The machine does not need to be recalibrated; a mathematical formula can be applied to the results of a patient on strontium to adjust those results.

The brand of strontium citrate I use is Doctor's Best Strontium Bone Maker. I have just posted the results of my latest DEXA scan on my blog. I am not allowed to give the URL on this site, but you can follow the link at the bottom right of my profile. It will take you there.

BoneLady

BoneLady

Hi! zeta,

The strontium malonate that Osteologix is researching is a once-daily tablet. They refer to it as NB S101. It must contain some inert ingredients, but I have not seen them listed on their website at www.osteologix.com.

I doubt that NB S101 contains aspartame. The reason aspartame is in Servier's strontium ranelate is that the product is a powder which must be dissolved in water prior to ingesting. The aspartame makes it taste sweet.

I doubt that Osteologix will divulge all their ingredients at this time, but you can email them at info@osteologix.com. Other ways to contact them: Tel: 804/747-6027, Fax: 804/747-6029, Mail: Osteologix, Inc, 4415 Cox Road, Glen Allen, VA 23060.

BoneLady

livnwel

Bonelady-I just started taking Dr.'s Best Strontium and I'm hoping for the best. I have read many postings about making adjustments with the DEXA machine when someone takes strontium, but I don't understand the reason why adjustments are necessary. Could you explain?

BoneLady

livnwel,

DEXA scans are normally read based on calcium as the main bone component. If you have been taking strontium, it will be present in your bones. Since strontium is heavier than calcium, it will amplify bone mineral density (BMD) results by DEXA scan.

The scan results will look better than they actually are if no correction is made. The correction is simply a mathematical formula; the DEXA machine itself is not adjusted. One formula subtracts 10% off the BMD in gm/cm2.

The 10% correction is controversial. Servier, the manufacturer of strontium ranelate (Protelos 2 g/day), says the combined effects of strontium distribution in bone and increased X-ray absorption of strontium compared to calcium account for 50% of the measured change in BMD over three years with their product.

I could not get the radiologist to correct my scores, and, believe me, I tried! I provided written material about correcting for strontium use, included my dates of use and dosage, and spoke with the radiology technologist, who wrote a personal message to the radiologist. All to no avail! I have heard from several other people who have had similar experiences.

But do not fret too much about the correction, or lack of correction. Servier has also written that it is not necessary to correct a patient's scores each time because they have found a 0.74 correlation between improved uncorrected scores and decreased fractures. What is most important for all of us is to decrease the risk of stress fractures.

If your uncorrected T-scores are better after taking strontium for a year or two, then you can feel good about your choice of therapy. That is how I choose to view my results, which are posted on my blog.

BoneLady

Gatekeeper

I agree with BoneLady. I'll inform the tech that I've been taking strontium, but been off it 2 weeks before the dexa at my Dr.'s suggestion.

Sure hope this goes to prescription form soon. I don't think my mom can find anything of quality in her town, and she won't order things off the internet. <s>

April995

From what others have wrote . I thought if your having a DEXA, you where suppose to stop taking Strontium Citrate about 4 weeks before taking a DEXA, so you do not get a false reading!!

When I was taking Strontium I asked the Tec about ajusting the machine for Strontium Citrate. He never heard of such a thing, and also Strontium!! That was at the beginning of the year.
My Osteo Dr. never heard of Strontium either. I have never gone back to that office, although he was very Knowledgeable about me taking Osteo Drugs. I don't take any.

My regular Dr. never heard of Strontium also. I send him Emails about it, which he is now looking into it.(he is a personal friend).

I think I have been the only one here that Strontium has caused me to have a swollen left Ankle and awful heart burn down the middle of my chest! I'm not over weight, and since I stopped taking strontium, I do not have any heartburn from any food I eat, but very strange that I still get a swollen ankle, but not as bad. The Dr. cannot figure out why!
If those side effects didn't happen, I would still be taking it.
When I did call Drs. Best, and asked if that was a side effect to taking it, or was there salt in it, she said NO!!
Makes me wonder!

I feel you really have to be Pro-Active about your Health.

Take Care,
April

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