I am having trouble with depression.
Dealing with eight compression fractures and permanently abused, painful muscles due to my spine being shaped like a question mark does not help. My complementary medicine MD suggested that I try swallowing tryptophan and/or 5-HTP to increase serotonin in my brain. Fine, I had the same idea.
So, I did do this for several months. Then I stumbled upon research by Gerard Karsenty of Columbia University which proves that nearly all of the tryptophan that is swallowed is converted to serotonin in the GUT. And serotonin production in the gut causes osteoporosis.
Serotonin in the gut cannot reach the brain through being absorbed into the blood because serotonin does not cross the blood-brain barrier. It is only the small amount of tryptophan that is not converted to serotonin in the gut that gets into the blood and does cross the blood-brain barrier which helps depression. It is converted to serotonin in the brain.
So, I have stopped swallowing tryptophan and 5-HTP. I now hold about 200 mg of tryptophan pure powder in my mouth for about 10 minutes and then spit it out. Don't swallow! I do think that enough of it is absorbed into my blood to help with my depression. Dosage varies, usually 2-4 times a day.
This could be the reason that the SSRI drugs cause osetoporosis.
My MD was dumbfounded by this and very glad to get the information. Like most doctors, he has way too many patients and not enough time to learn things about the therapies he uses.