I had a once a year Reclast IV treatment in March 2011 and started having severe bone and joint pain in left leg (from knee down). Pain started slow but has gotten increasingly worse. Its been 10 months since the IV. I have decided I will never get another IV treatment but would like to hear from others who have pain like this, how long did it last after stopping the treatment. Does it get better after a year or does this stay in your system longer? I also have severe muscle atrophy in this leg. The doctors have run every test under the sun and since they can't find anything wrong I'm thinking the atrophy is from lack of use because of the severe pain--every step I take hurts. I use to be a very active 54 year old. I use to exercise 4-5 times a week. Now I can barely walk. Can anyone tell me when I might feel better? How long does this drug stay in you? Thanks for any insight you can give me. The doctors don't know much.