Odanacatib

• By Sally48
• Reply 3210075
• July 14, 2012 at 9:31 am
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Thanks for the post......very interesting! As with any new drug coming on the market, caution is advised. Long term side effects???

• By Sally48
• Reply 3213174 · In reply to 3212413 by dxaguru
• July 15, 2012 at 3:45 pm
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A few years ago I read of a doctor that would not prescribe medications to his family or friends that had not been on the market for 10 years. In my mind ten years after the drug is on the market would give patients the knowledge of the benefits of the drug, and the adverse side effects of the drug. Bisphosphonates comes to mind. Here is an example:http://www.drug-injury.com/druginjurycom/2012/06/bisphosphonate-femur-fract ures-fosamax-cases-medical-diagnosis-difficult-doctors-radiologists-orthope dics-surgeons.html

• By cybertray
• Reply 3435956
• October 6, 2012 at 10:06 am
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I am currently taking part in a study for men and osteoporosis. I have less than a year left in the study. I have been taking 50mg of Odanacatib or a placebo once a week, plus 5600iu Vitamin D weekly and 1000mg Calcium daily. I have had no side affects that I can attribute to the study, been on a couple years now. Time flies. I have been waiting for someone to mention this drug. Then I found this article... http://www.huffingtonpost.com/2012/07/12/odanacatib-osteoporosis-drug-fract ure-bone_n_1666631.html

All I know is that I have felt stronger bonewise and healthier since being on this regiment. I refused bisphosphonate drugs that my original doctor prescribed. Called my friend who is a researcher at the University and she set me up. I am so glad, and I changed doctors too. The new drug will probably be expensive and many will not be able to afford, but I am thankful that I was able to be a part of this study that could eventually help someone else in their difficulties with osteo.

• By BMJ6372
• Reply 3468173
• October 18, 2012 at 8:30 am
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I've been recently diagnosed with both osteopenia and osteoporosis. I got a stress fracture in my knee which led to the diagnoses. My lumbar spine T score is really bad at -3.88. Yet I have no back pain of any kind. My femoral neck score was -2.36. I'm a 49 yr old guy. There are some thyroid issues in the family. But doctor said my blood tests show nothing wrong with my thyroid. I've been on a crash course of studying up on the meds for Osteoporosis and it has left me rather depressed. This drug sounds promising. If it comes out on the market how soon would it available?

• By ewcollins
• Reply 3468509 · In reply to 3468310 by windblown
• October 18, 2012 at 10:11 am
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Windblown - I do not subscribe to thepharmaletter, but sometimes articles are available for free for a limited time after they are published.

• By ewcollins
• Reply 3468551 · In reply to 3468173 by BMJ6372
• October 18, 2012 at 10:23 am
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BMJ6372 - One must find the root cause of their osteoporosis and correct that. Osteoporosis medications do not correct the root cause. In my case, the root causes were insufficient vitamin D and borderline low testosterone. These problems have now been corrected and I feel much better. I am 60, and although I run pretty hard, I have never had any type of fracture.

I take the following "osteoporosis related" daily supplements (NOT ALL AT THE SAME TIME):

Boron (B) - 3 mg (Boron Citrate / Aspartate / Amino Acid Chelate)
Calcium (Ca) - 1065 mg (Calcium Citrate / Malate / Carbonate)
Lactoferrin - 250 mg (Lactoferrin)
Magnesium (Mg) - 546 mg (Magnesium Oxide / Gluconate / Citrate / Glycinate / Malate)
Strontium (Sr) - 680 mg (Strontium Citrate)
Vitamin D3 - 5950 IU (D3 Cholecalciferol)
Vitamin K - 75 mcg (MenaQ7 Menaquinone)

I also have been applying AndroGel (testosterone) since 02/05/2011.

• By spunkyblondie
• Reply 3471501 · In reply to 3468173 by BMJ6372
• October 19, 2012 at 11:18 am
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In addition to diet, what about weight bearing exercise? I've recently started going to a Body Pump class (weight lifting).

I think many of us got a bit depressed by the osteo diagnosis. There is a lot of good advice here and if you spend some time here every day, you'll get up to speed.

Ewcollins gave you a good list to follow with respect to supplements. The dairy industry has done a good job of selling milk and dairy products, but treating osteoporosis is so much more than just calcium.

• By ewcollins
• Reply 3471760 · In reply to 3471663 by windblown
• October 19, 2012 at 12:35 pm
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Windblown - I have hormone loss, and that is why I have been applying AndroGel (testosterone) since 02/05/2011.

I was skeptical at first; I thought that once bone was gone, then it was gone forever. All I hoped for was that things would not get any worse. My physician, who is also trained as an endocrinologist, told me that I was mistaken, and that once my testosterone levels stabilized, then of course I would start rebuilding lost bone. They were correct. Although it took 18 months, I notice the difference and I feel MUCH better. My posture has improved and I am now running faster than I did three years ago.

One must select a treatment that they are comfortable with and then patiently stick with it.

• By ewcollins
• Reply 3472148 · In reply to 3471971 by windblown
• October 19, 2012 at 2:34 pm
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Windblown - Here I am at a 6-hour run last Sunday - http://rci.rutgers.edu/~mocker/running/photos/glirc_6_hour_run_2012.jpg .

I covered 27.77 miles! This is better than I did at this same race in 2002.

• By BMJ6372
• Reply 3545265
• November 15, 2012 at 9:56 am
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How fast does the FDA approve drugs like this?

• By cybertray
• Reply 3552089 · In reply to 3468326 by windblown
• November 17, 2012 at 3:52 pm
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Thanks windblown. For you and many more with this silent ailment, I believe these studies are important and help all of us better understand our framework and our potential frailty. Hopefully there is a cure but also knowledge is a way for us to find ourselves in faith that Divinity has all things in control and is the ultimate cure for every ailment if we only believe. My faith is not in studies, but beyond and far above studies. Living right and eating right will take us further with osteo issues than pills and shots. I like to read about what others are doing with nutrition and minerals. We are all made from different soil types and some components of minerals may be different than others so we all need to look to the One who knows us individually. Doctors practice but knowledge is divine. Not everyone will benefit from the same treatments, but we have hope that what we do in this life matters and it will ultimately help others in some way. Thanks again for your inspiration.

• By spunkyblondie
• Reply 3552289 · In reply to 3545265 by BMJ6372
• November 17, 2012 at 5:10 pm
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The FDA gives their approval when big pharma's check clears. Ha!