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Seems similar to Forteo but with perhaps a better safety profile and less frequent dosing
http://www.drugs.com/clinical_trials/radius-investigational-bone-anabolic-a gent-ba058-increased-bone-mineral-density-bmd-key-fracture-7852.html
A quote from that article
. In the 12-month treatment period, patients receiving the highest dose of BA058 increased lumbar spine BMD by 12.9 percent at 12 months compared with 8.6 percent in the Forteo(R) group and boosted femoral neck BMD by 4.1 percent compared with 2.2 percent for the Forteo(R) group.
Impressive
Hi drizzit: I saw this too and was interested in the fact that it's a PTHrP (parathyroid hormone related protein) form of parathyroid hormone. This type doesn't have the hypercalcemia problems seen in a small group on Forteo (PTH 1-34). I had a slight problem with increased calcium levels on Forteo which went away when I finished it. For this reason no one would give me high dose D because it would further raise my ionized calcium, and cause many other terrible problems, and my 25 OH D was 7 yikes, when first tested, but now is higher but not high enough to be considered non deficient.
For anyone with hypercalcemia be careful with therapeutic doses of D, since it will raise your calcium level, into the danger zone, so we can't tell everyone to just take extra D unless they know their total and ionized levels of CA first. Most don't have to worry about this; I'm from another planet, so my labs are all over the place ;0) he he.
thanks for the info...it sounds exciting. when do you think the drug will be available?
That's interesting. Are they doing this by IV or injection? Do you know?
Does anyone know if there is a black box warning with this new drug as with Forteo?
Take care.
Cyn
Windblown,
You mentioned ionized calcium. Once a naturapath checked my ionized calcium and it was a couple of points high. 132 in a range of 110 to 1.30. Regular dr said it didn't mean anything. Tell me more about this. Are you going to an md?
Time to market?
Well another year for phase 3 trials. ... 6 months to gather the data and submit it to FDA...... 8 - 12 months for FDA to consider the data.
hmm at least 2.5 - 3 years is my bet.
Cyn
any black box warning would come out with FDA approval so there is no way to know if there will be one or not. I have not seen the animal tests to see if it was like Forteo and caused cancer problems in mice.
Hi Osteochick, how are you??? There's a lot of debate over the validity of ionized calcium tests since most docs believe a total calcium is best. I just happen to have a mineral metabolism doc that likes that test for some reason--don't know why. I have had total CA done that were normal and ionized that were not normal, and that's really hard to explain since they should be the same reading unless you have hypercalcemia which some believe--not all that's for sure--that an ionized will give you more info. Frankly I don't understand that logic, because a total CA tests both bound and unbound CA, so you would think that test would be the same as ionized which tests unbound (free circulating) CA.
I see a doc at an osteoporosis research clinic at a Univ Hosp Med Center, where most of their time is spent on research but they do see patients once a week, not sure if this could explain her like of ionized CA tests.
Take Care.
Hi Osteochick, one thing I forgot, when you have a score that is .2 above normal that's considered slightly elevated CA and they don't start to worry until it goes say 1-3 whole points above the normal range, or you consistently have elevated scores like yours over time.
Drizzit:
You have an incredible knowledge about the
ZP-PTH patch for treatment of osteoporosis. Do you work for the company? Do you know if there will be
any Phase 3 trials at any hospitals or clinics in
Florida in the near future? Are there any other
patches similar to the patch being tested by the
Zosano Pharma company currently being tested?
discover
I only posted an article I found on a new drug. I did not see it was a patch? Is the ZP-PTH patch the same drug I posted the link on?
No I am a science teacher at a High School in Montana I do have Chemistry and Geology degrees but that is about it :)
I can't answer your questions
sorry
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