I am researching Biosil for osteo. I came upon this study.
November 13, 2010
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Silicon for Bones and Joints
BioSil is the Ultimate Silicon
Hair, Skin & Nail Strength
Bone & Joint Structure
New Evidence for the Important Role of Orthosilicic Acid in Bone Metabolism
Silicon Enhances Calcium's Bone Benefits
Silicon Uptake is a Major Dietary Determinant of Bone Mineral Density (BMD)
Studies at UCLA and other research institutions have proven that silicon as an essential element required for the normal growth, development, and integrity of bones, joints and connective tissue; as well as for hair, skin, nails, arteries and cartilage. Literally every part of the body that requires strength and elasticity requires silicon.
Specifically, silicon is associated with collagen formation, the fibrous protein matrix which provides support for body structures such as cartilage and bones. This is why optimal bone health depends upon silicon as well as calcium. Inadequate silicon intake has been associated with weak, brittle nails and weakened capillaries and arteries; because the essential protein matrix is deficient.
Our bodies process silicon inefficiently, and our ability to do even that diminishes as we age. Scientists currently estimate our daily requirement for silicon to be between 5 to 20 mg. per day. This is clearly why BioSil supplementation is necessary to ensure healthy bones, joints, hair, nails and connective tissue.
BioSil Contains the Only Bioavailable Form of Silicon
The only bioavailable form of silicon is orthosilicic acid [Si(OH)4], not silica [Si02]. Silica is silicon dioxide, which is not bioavailable. Silicon is found in food (and horsetail) as silicates, which are likewise not bloavailable. All dietary silicon must be dissolved in the stomach into orthosilicic acid, the monomeric (single unit) correct form of silicic acid, which is absorbed and used by the body. Silicic acid, however, is unstable. In concentrations over 1 ppm (the amount typically found in mineral water, orthosilicic acid readily polymerizes into long chains, converting in the process back into a non-bioavailable silicate. BioSil is a revolutionary breakthrough product, stabilized and concentrated at 20,000 parts per million and providing 1 mg of highly biologically active and absorbable silicon in just one drop! One bottle of BioSil equals the orthosilicic acid in 600 liters(!) of mineral water!
"The orthosilicic acid in one bottle of BioSil equals 600 liters of mineral water!"
BioSil and the Bones
Silicon plays a very important role in bone calcification, especially in the growth of new bone. The cells that make bone (osteoblasts) begin constructing a connective tissue matrix. When this is done, the osteoblasts switch their function, and begin to fill in this matrix with minerals. This process requires silicon.
In a clinical study of 53 women who had osteoporosis, silicon supplementation produced an increase in bone mineral density, or an increase in bone mass. Indeed, silicon seemed to be the only thing that could alone help relieve the destructive process that results in osteoporosis. Eisinger and Clairet (1993).
"Bone health depends on Silicon"
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BioSil and the Joints
Connective tissue is composed of cells which produce the fibrous protein matrixes of collagen and elastin, as well as the hydrated network of amino-sugars called glycosaminoglycans (GAGs) or mucopolysaccarides (MPSs). Silicon is known to act as a cross-linking agent which stabilizes the glycosaminoglycan networks. A major function of GAGs is to attract and hold water in the joints. Why is this important? Because articular cartilage in the joints has no blood supply of its own. Healthy cartilage therefore derives all its nutrition, as well as its cushioning effect, from the supply of water in the joints.
Glucosamine,an amino sugar needed for the production of GAGs, is quite well known as an effective alternative support for joints. Given silicon's physiological association with GAGs, combining silicon with glucosamine will increase the effectiveness of the latter for promoting joint and connective tissue health.
Another important aspect of silicon is its essentialiry for the formation and maintenance of healthy joint cartilage. Chondroitin sulfate requires silicon to construct the chondrocytes, the sponge-like material in the joints that nourishes articular cartilage. In fact, silicon, in the form of silanolates, actually reconnect together the chondroitin sulfate molecules in joints. Increased hydration promotes connective tissue elasticity and cushioning. So vital is silicon to healthy joint function that in `Maximizing the Arthritis Cure'; the follow-up book to "The Arthritis Cure"; mention is made to the addition of silicon to everyone's diet, because of the important role silicon has been found to have in bone and cartilage formation.
BioSil and the Heart
A substantial amount of the body's connective tissue in our bodies is the linings of our veins and arteries. Clinical studies show that silicon progressively drops in the artery wall. In seniority and heart disease, silicon in the aorta is only 15% of that of a child. Silicon makes the inner lining of arterial tissue (tunica intima) less permeable. Since arterial damage is usually the first step in plaque formation that can eventually clog an artery and lead to surgical consequences, researchers are beginning to think that silicon deficiency may predispose someone for certain types of heart disease.
BioSil and the Skin
Skin comprises the largest organ containing connective tissue. It's 15-20% of our body weight. Silicon from BioSil was shown to increase the collagen concentration in the dermis of the skin of calves up to 12.5% (Calomme and Vanden Berghe 1997). Silicon is crucial for activating the hydroxylation enzymes for crosslinking collagen, which improves the strength and elasticity of this fibrous protein. Better collagen means better skin; more elasticity, fewer wrinkles.
BioSil & Hair and Nails
Hair - The outer shaft of hair is intended to be very strong, essentially as strong as any fiber. This outer shaft of hair, that also provides elasticity and strength, is rich in silicon. BioSil can help hair grow thicker and stronger. Hair with higher silicon content tends to fall out less and has more shine and luster.
Nails - The predominant minerals in nails are calcium, silicon and sulfur. A sign that silicon may be systemically deficient is nails that are brittle or soft.
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The Essential Nature of Silicon
In her years of research, Edith Carlisle demonstrated that silicon is essential, and in nature, silicon is virtually everywhere. Next to oxygen, it is the second most abundant element, comprising 28% of the earth's crust.
Our bodies contain about seven grams of silicon. In blood, silicon is in the form known as orthosilicic acid, which is the only form that can be absorbed, whether by a plant, an animal or humans.
BioSil is orthosilicic acid, stabilized in this singular form, so it is immediately available for absorption. This bioavailabiliry of BioSil is precisely what makes it so much more valuable than any other silicon form.
In a clinical study at the University of Antwerp, several leading silicon supplements were tested on volunteers for a week. There was a one week washout period between each dosing period, during which the ( subjects ate a regular diet. BioSil was compared with a commercially available horsetail extract and a silica gel. Mineral water was used as a control. Dr. Leigh Broadhurst, perhaps the foremost proponent on dietary silicon today, cites this study in her lectures around the country (see graph).
"The silicon from BioSil showed an increase in the urine and in the bloodstream. We measure the urine output of trace elements, not because it's being wasted, but because that shows you that it's been metabolized, and the body takes what it needs and excretes what it doesn't. But the most important thing is that we saw an increase in the bloodstream only with BioSil."
The BioSil Advantages
High Potency - As BioSil is 20,000 times more concentrated than mineral water, one drop of BioSil (1 mg) is equal to an entire bottle of mineral water!
Maximum Absorption - BioSil contains stabilized orthosilicic acid, the only form of silicon absorbed directly through the stomach wall and the gastrointestinal tract into the bloodstream.
Cost-effective - BioSil is the most cost efficient solution for healthier bones, joints, and connective tissue, starting at only 24 cents a day!
Maintenance 6 drops/ 100 days $0.24
High Use 10 drops/60 days $0.40
Total: 600 drops per bottle. Each drop contains 1 mg of silicon.
Broadhurst C.L. (1999) "Silicon's essential benefits"
Calomme M.R. and Vanden Berghe D.A. (1997) Supplementation of calves with stabilized Orthosilicic Acid: effect on the Si, Ca, Mg and P concentration in serum and on the collagen concentration in skill and cartilage. Biological Trace Element Research, 56, in press.
Calomme M.R. et. al. (1998) Supplementation of calves with stabilized Orthosilicic Acid: effect on the Si, Ca, Mg and P concentration in serum and on the collagen concentration in skill and cartilage. Biological Trace Element Research, 56, in press.
Carlisle E.M. (1970) Silicon: A possible growth factor in bone calcification. Science, 167, 279-280.
Carlisle E.M. (1970) In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick. Journal of Nutrition, 106, 478-484.
Carlisle E.M. (1986) Silicon as an essential trace element in animal nutrition. Silicon Biochemistry, CIBA Foundation Symposium 121, John Wiley and Sons, New York, 123-139.
Eisinger J. and Clairet D. (1993) Effects of silicon, flouride, etidronate and magnesium on bone mineral density: a retrospective study. Magnesium Research, 6, 247-249.
Frey K.S., Pottery G.D. et. al. Plasma silicon and radiographic bone density in weaning quarter horses fed sodium zeolite A. Equine Vet Science, 12, 292-296.
Loeper J., Goy-Loeper J. et. al. The antiatheromatous action of silicon. Atherosclerosis, 33, 397-408.
Reprinted with exclusive permission by Jarrow Formulas.
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