For the past couple of years I'd been supplementing with 100 mcg of Vitamin K2 MK-7.
The other day I encountered this statement
"Today, I found another difference between MK-4 and MK-7. I was reading a paper about SXR-independent effects of vitamin K2 on gene expression. The investigators found that MK-4 strongly activates transcription of two specific genes in osteoblast cells. Osteoblasts are cells that create bone tissue. The genes are GDF15 and STC2 and they're involved in bone and cartilage formation. They tested K1 and MK-7, and in contrast to MK-4, they did not activate transcription of the genes in the slightest. This shows that MK-4 has effects on gene expression in bone tissue that MK-7 doesn't have."
As a consequence I'm looking into supplementing with both the MK-4 and MK-7 forms. I haven't decided on the dosages...anyone have any thoughts?
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