DIM question

I have read on here about the DIM supplement. Can anyone tell me where to purchase it?

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It's a well-known fact that a healthy diet should include lots of fruits and vegetables. However, most Americans do not consume the recommended amounts of these foods. A national campaign called "5 a Day for Better Health" was initiated by the National Cancer Institute, the National Institutes of Health, and Produce for Better Health Foundation. The goal of this partnership is to encourage Americans to increase the daily consumption of fruits and vegetables to at least five servings a day. Recently, however, a substantial amount of evidence indicates that not all vegetables are the same in nutritional value and health benefits. Cruciferous vegetables (such as broccoli, cabbage, and cauliflower) have more nutrients per serving than many other vegetables.

Nutrients called phytochemicals found in cruciferous vegetables provide health protection by decreasing the effects of cancer-causing chemicals. The most active and important of these phytochemicals, diindolylmethane (DIM), has shown great promise as an anticancer agent.

Q. What is DIM?

A. DIM is an indole phytonutrient (plant nutrient) found only in cruciferous vegetables. When broccoli or any other cruciferous vegetables are chewed, plant enzymes are released. Once these enzymes are exposed to stomach acid, a compound called indole-3 carbinol (I3C) is formed which, in turn, yields DIM.

Q. How does DIM work?

A. DIM has a direct effect on the hormone estrogen and how it is metabolized.

Estrogen has many beneficial activities in the human body: regulating the growth and development of reproductive organs, controlling the growth of the uterine lining, assisting in promotion of fertilization and pregnancy, maintaining the normal structure of skin and blood vessels, maintaining bone structure, and regulating various metabolic processes. However, excessive prolonged exposure to estrogen is also associated with serious health problems. Women with higher levels of estrogen circulating in their bloodstreams have a higher incidence of breast cancer. And, certain estrogen metabolites are directly linked to the development of several types of cancer.

Scientists have discovered that 2-methoxyestrogens, one of several types of estrogen, can actually inhibit the growth of malignant tumors. Researchers have speculated that increasing production of this "good" estrogen would be very beneficial. This is where DIM enters the picture-DIM can successfully increase the ratio of "good" to "bad" estrogen. DIM supplementation specifically promotes beneficial estrogen metabolism and helps restore a healthy hormonal balance.

Q. Is there any research that shows DIM improves health?

A. Many impressive studies have led to understanding DIM's effect on cancer. Scientists have determined DIM actually inhibits cancer cell growth. DIM has also been shown to enhance the activity of enzymes found in certain pathways in the liver. These enzymes are important for healthy estrogen metabolism that reduces the risk of cancer development.

Q. Is DIM for women only, since it decreases the harmful effect of estrogen?

A. While estrogen is generally thought of as a female hormone, men need and produce small amounts of estrogen, too. In fact, it's believed that in men, estrogen is converted from testosterone, the most abundant male sex hormone. This estrogen conversion from testosterone, with further metabolism of estrogen into estradiol, estrone, and the hydroxylation of "good" and "bad" estrogens, occurs in the liver, the same place estrogen metabolism occurs in women. In men, estrogen assists in the production of healthy and viable sperm. Research has determined that harmful alterations in the "good estrogen" to "bad estrogen" ratio are responsible for the development of certain cancers in men and women.

Q. What is the best way to increase DIM & "good" estrogen?

A. DIM is extremely insoluble and poorly absorbed without a biodelivery vehicle. DIM supplements need to provide an effective delivery system, preferably one that has undergone testing in animal and clinical settings.

(DIM provides many advantages over indole-3-carbinol, another cruciferous phytochemical available as a dietary supplement (13C) I3C is an unstable precursor that requires activation in the stomach to be converted into DIM. This means I3C must be taken at a much higher amount and can undergo unpredictable and undesirable chemical reactions in your stomach or colon. DIM is by far the preferable supplement.)

Q. Are DIM supplements safe?

A. DIM has been taken as a dietary supplement for many years without any reports of adverse effects, and DIM's safety has been evaluated. The use of DIM in an animal study at hundreds of times the amount provided in dietary supplements produced no adverse effects. Some individuals may notice some minor stomach upset with DIM supplements. Taking DIM supplements with food often eliminates this problem. Harmless changes in urine color may occur with the use of DIM supplements. This color reflects the presence of DIM metabolites that have an amber color. Individuals who eat large amounts of DIM-containing cruciferous vegetables would notice similarly colored urine. Drinking 6-8 glasses of water per day will often eliminate this problem. However, if individuals notice a change in urine odor or haziness in their urine, they need to consult their licensed health care practitioner. These changes are not a result of DIM supplementation and could instead be the signs of a urinary tract infection.

Q. Wouldn't eating more broccoli and other cruciferous vegetables be more natural and healthy than taking DIM?

A. Increasing consumption of cruciferous vegetables may be beneficial for most people. However, many individuals have good intentions of eating more broccoli, cabbage, and cauliflower but find they don't or can't actually do so. While Americans eat 3.6 servings of vegetables and 1.6 servings of fruit daily—iceberg lettuce, tomatoes, French fries, bananas, and orange juice were the most commonly consumed items. Dark green and cruciferous vegetable intake was quite low.

Q. How much DIM should be taken?

A. Studies show the most effective amount of supplemental DIM is 30 mg of absorbable DIM per dose, with daily doses of 60 mg for women and 120 mg for men. (The lower the absorbability of DIM, the higher the dose required to meet these levels. Plain DIM is not very well absorbed.)


There are many risk factors associated with cancer: some that can be altered (such as smoking in lung cancer) and some that cannot (such as gender in breast cancer). Scientific evidence suggests about one-third cancer deaths are nutrition-related and could be prevented. While many individuals try hard to reduce their own personal and modifiable cancer risks, this is not always easy to do. Using supplemental DIM is a remarkable way to reduce cancer risk. Source material available upon request.

Dr. Marcus Laux received his doctorate from the National College of Naturopathic Medicine (NCNM) in Portland, where he serves on staff as a clinical professor. Dr. Laux is the co-author of "Natural Woman, Natural Menopause" (Harper Collins, 1997), a complete plan for staying naturally well through menopause and beyond.

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I got all that, I am looking for a reliable place to purchase the DIM supplements.

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Oximax PRO (exceptional blend of antioxidants) contains optimal levels of natural beta-carotene, mixed carotenes and other antioxidants, such as vitamins C, E, and selenium, along with powerful plant antioxidants found in green tea and grape seed extract, to provide cell protection and immune system support.

Take 2 capsules twice a day with food or as directed by your healthcare practitioner.
Found where?

Groups of well-known antioxidants include: catechins, which are found in black and green teas and some fruits; coumarins, which are found in citrus fruits; indoles, which are found in cruciferous vegetables, such as broccoli, bok choy, brussels sprouts and cabbage; and carotenoids, which are the largest group of naturally occurring antioxidants. Carotenoids are plant pigments that have vitamin-like properties. They give color to brightly colored vegetables, like squash, carrots, peppers and tomatoes. Beta-carotene is the most common carotenoid.

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online, do a search.

i have read though the it's inconclusive whether taking it in supplement form is a good thing. i can't find it back but i read a study that showed it did more harm than good.

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I just ordered some from bioresponse. This is the company that supplies the dim supplements for clinical trials. It hasn't arrived yet. Also, online i found a brand called Activamune. I went with the bioresponse because of the clinical trials.


you can order it from their webcite, or if you click "where to buy" it will give you other brands that use the bioresponse formula.

With respect to safety, I have read that the precurser to the dim supplement, called 13C, was not as safe as DIM.

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Thank you so much girls for the links. I start chemo and radiation on the 26th. I am going to wait until that is over before I start the DIM.

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I have been taking DIM for a few months now and I have been purchasing them here.

http://www.amazon.com/Source-Naturals-Diindolylmethane-Tablets-tablets/dp/B 000GFPCZ2/ref=pd_bbs_sr_1?ie=UTF8&s=hpc&qid=1232405106&sr=8-1

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you can purchase DIM supplements in health food stores as well as in many grocery stores, including Whole Foods.

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before i researched it i couldn't find it at whole foods. wait at least 3 months after chemo before taking it. you don't want to do anything to interfere with chemo working to the best of it's ability.

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I was wondering how long I should wait after chemo to start it. Thanks for the info on that.

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i want to say it takes 3-4 months for the chemo to work out of your system. i think?

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I have a question about the optimal dosage of absorbable DIM to diminish BRCA1 risk. I also have a guestion about Bioresponse DIM vs ActivaMune - http://www.activamune.com/science.htm. I read on a study that no more than 108 mg is needed for breast cancer prevention. However at ActivaMune they told me that I would need 750 mg (at 53% of active DIM - that equals 397.5 mg a day). BioResponse's contains 25% active DIM.

I was also advised by ActivaMune (their studies were at Berkley) that I would be better off to take their optimal dosage every other day than taking half a dosage every day. So if I can't afford two bottles of their 375 mg formula, I would purchase one bottle and take 4 supplements every other day rather than 2 supplements every day. That is really confusing to me.

I would really appreciate insights on this topic. Thank you in advance!!

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Hey Friend! I got my DIM in Shreveport. There are some Natural stores in Longview. Jack's may have it. My onc put me on a bunch of supplements during my treatment so be sure and ask if you can take it during chemo.

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I have bought my DIM from Bioresponse in the past but now I buy it from www.mothernature.com the brand I buy is DIM-Plus Nature's Way. Their prices are reasonable. I just adjust how many I take depending on the # of mg in the capsules I purchase.

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