Today was the first day that my father had bad blood results. He has had 3 rounds of carbo, taxol, avastin and goes for #4 next week. His white blood cell count was very low today...it was 1700 last week and 400 this week. The doctor said they hate to see it below 500. He recommended a neulasta shot a day after chemo next week. Here is my dilemma: He has really had NO side effects with the exception of fatigue and joint/bone pain. The joint and bone pain comes on 2 days or so after chemo and has been lasting longer the further we go into his regimen. The doctor said the main side effect will be bone pain. My feeling is if he already has this pain and you compound it with more, it is really going to do a number on his spirits. The doctor said he can take more pain medication if the pain is too bad. They said for him to really monitor his temperature and any sign of fever or sickness to call right away and they will get him in for IV antibiotics. I almost think it may be easier to take precaucions not to get sick (washing hands, away from sick people, etc) versus inviting more pain into the equation. What do you think? How bad is the pain from this shot?