I am the primary caregiver for a dear friend, and her 12 year old daugther will be joining my family if her mom dies. She has been on radiation for brain mets, carbo/alitma, alitma alone, taxotere and now is starting a trial at MGH in Boston for Tarceva with MM121. She does not have the gene mutation. Is anyone else part of this trial? And also - if this combination does not work for her, are there other options, or is a clinical trial usually the "last resort"?