Mom finished 3 rounds chemo carbo/Alimta/Avastin. 3 weeks later she had a PET. Onc visit shows cancer activity on side where she had surgery. It shows outside the lung and before the rib cage. Onc feels cancer is active. He said radiation did a good job on the tumor, but activity is outside the radiation area. He tells mom to take a chemo vacation. Get her tooth fixed (implant) and go travel for a few months.
Onc wants to get her into a trail GSK1120212. He needs a base line to start, so he orders a CT scan. He needs a measurable tumor to get her into the trial. He said they are seeing good results with breast cancer on this trial, and mom's cancer acts the same way. It would be Phase II.
1 week later, Tue 5/22/12 she got her CT scan and results. She has planned the dentist visit and vacation with her sisters. Onc comes in and shows CT image and results. He can't find anything on the CT. He tells us that without the PET scan, he would have thought that there was no activity going on. He recommends 3 more rounds of carbo/alimta/avastin. Start immediately. After chemo, he said he will put her on Alimta for maintenance. Mom was shocked. No break, no long vacation, and more of the triplet cocktail that knocks her down.
Ok, did she just get good news? Is it worth doing assay testing if a new tumor developes? Would it even matter now that she is this far along with KRAS? Should she get a second opinion from Dr. Alice Shaw like a few others on team inspire have done?
I asked mom's Onc if he would work with other Oncs' and he said "Sure, get a second opinion. We encourage that. You can go anywhere you would like too." I asked about HSP90, and he said they are not FDA approved, and mom would only get FDA at Mayo unless it is one of the trials they are in. His trial that he originally talked about is like docetaxol. That did not work. Her tumor grew when she was on the cisplatin/docetaxol. I told him that I read where platin drugs do not work with KRAS, and he said there is nothing else out there for KRAS. It is standard treatment in oncology.
I also learned that her first rounds of cisplatin/docetaxol were standard treatments after LC surgery. I thought it was her first line. He said no, the carbo/alimta/avastin were first line. He also said that to get her into a trial, she needs to stay on that triplet. If he tried Gemzar or anything else, it would be second line and she would not qualify for a trial.