I meant to post this specifically under Stage IV, so I am re-posting:
Is there anyone out there with my mom's diagnosis who can share their experience with Tarceva/Avastin (or Tarceva alone)? My mom's diagnosis is Stage IV Adenocarcinoma with Bronchioalveolar features (she has a mix of Adeno and BAC). She did 5 rounds of Carboplatin/Taxol (adding Avastin as of round 3) and had good results (shrinkage in the multiple nodules throughout both lungs) as of the first follow-up CT. But since there was some growth in one of the lung nodules in the 2nd follow-up CT, the oncologist cut short the Carbo/Taxol (did only 5 rounds instead of the initially planned 6 rounds) and has put her on Tarceva/Avastin. The good news is that she tested positive for the EGFR 21 genetic mutation -- which means she should respond well to Tarceva. We hope, we hope!
I'm seeking some help in understanding how the Tarceva/Avastin helps with her particular diagnosis where there is a "mix" of 2 types of cancer. It's my understanding that the Adenocarcinoma is the "faster growing" cancer (which the Carbo/Taxol was supposed to attack). The Tarceva (again, from my limited understanding) is more targeted towards the Bronchioalveolar cancer (the slower growing cancer). So my main questions are these: 1. Does the Tarceva target the "Adeno" element, or is it only effective with the Bronchioalveolar element? 2. The oncologist seemed to waiver on whether to do Tarceva alone or Tarceva/Avastin together (he said the studies for Tarceva + Avastin for people who have the EGFR 21 mutation are not yet complete/conclusive) So is there anyone out there who's had experience with any particular regimen (Tarceva on its own or Tarceva + Avastin)? 3. Is there anyone who's got my mom's diagnosis who's had good results with Tarceva or Tarceva/Avastin?
My mom's diagnosis with this Adeno-BAC mix seems to be particularly troubling. So I'm seeking any and all insight I can gain from anyone out there who's having a parallel experience. Any feedback would be greatly appreciated. Thank you so, so very much!