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Confused by doctors

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My husband is 43 years old he was diagnosed with NSCLC and adenocarcinoma in March 2009. We discovered he had cancer when he complained of pains in his right leg. We underwent a hip replacement. Then mets progressed to his brain (had gamma knife), adrenlain glands and a few lymph nodes. We underwent two different treatments but nothing had worked.

His lungs have NO tumor, NO fluid and as the doctors say No point of origin. What does this mean. Why is his prognosis so bad (they told me no more than six months) if he has nothing in his lungs. They told this is one of the most rare forms.

Can anyone shed some light so that I can understand.

God bless.

Barbara

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11 replies

Barbara, I see you are in Greece. Do they have any cancer treatment centers there? I will give you a link to read more on his type of cancer. Not knowing anything about Greece healthcare, I wouldn't know what to tell you. Good luck and take care, JC
http://www.cancercenter.com/adenocarcinoma.htm

Offhand I can suggest his lung tumors are small enough or in a bad enough place to be not detected. I had a brain tumor for quite some time before it showed up on a cat scan or MRI.

Did he have PET scan? That wouldn't have shown anything in the brain of course.

My other thought is that the biopsy is off, that the primary is either bone or brain --

My main thought is -- I dunno but I sure as you know what hope you find something out. I know nothing of the care in Greece, better or worse or just different, but something needs to be looked at more closely.

Tumor cells from unknown origin (Cancer of Unknown Primary Site or CUPS) are poorly differentiated or undifferentiated, making them difficult to interpret. The cancer is found in multiple locations, or is indicating metastatic disease without a clear primary. One doesn't know what kind of cancer it is to begin with, so it's hard to determine what treatment might be effective. There may not be enough experience to have much a priori idea of which drugs might be most effective.

Patients who have been through several chemotherapy regimens and are running out of options might want to consider chemosensitivity testing. Cell-based assay testing of cancers of unknown primary origin is particularly appropriate with cancers of this type. In this instance, it has produced some spectacular results with regimens the oncologist would not otherwise have considered. When the path is not clear or not treatment is known, it's worth considering.

It means they do not know where this primary originated, sometimes it goes undetected forever? I am not sure if eventually it is ever found in some cases. I think it is esential that the sensitivity testing be done so they know what if anything to treat it with. I wuld imagine your doctor has already told you this, if not then I would get another opinion. Because it would make me wonder what they could possibly go by to treat it with.
Good luck, please let us know what they determine.
God bless you both, it is bad enough when you know where the site of origin is let alone being in the dark as you are.
Sandy

Thank you all for your information. We did have a Pet scan prior to surgery in March o make sure how far the mets were in the bone. The pet scan showed a few lymph nodes and that was it. Once we had the hip replacement everything went crazy!

He was tested for mutations. Is chemosensitivity the same as genetic testing?

Thanks to all of you for your help.

God bless you all

Barbara

Barbara

Good question to be asking.

Genetic profiling tests, important in order to identify new therapeutic targets and thereby to develop useful drugs, cannot work successfully in predicting treatment response (clinical responders) for individual patients. Perhaps this is because they are performed on formalin-fixed, paraffin-embedded tissues or fresh-frozen tissue samples or unfrozen samples stored in RNA-preserving solution that were never actually exposed to the drugs whose activity they are trying to assess.

Cell-based functional profiling (chemosensitivity testing), is not hampered by the problems associated with gene or protein expression tests. That is because the functional methodology measures the net effect of all processes within the cancer, acting with and against each other in real-time, and it tests living (fresh) cells actually exposed to drugs and drug combinations of interest.

Cell-based functional profiling analyzes the (whole cell) systems' response to drug treatments, not just one or a few genetic targets or pathways (does the cell express a particular target that the drug is supposed to be attacking). Even if a genetic test can fine one type of gene or protein expressed, they will not be able to know if a targeted drug against those targets will actually benefit an individual cancer patient. Molecular assays are never tested in the presence of cancer cells.

Cell-based functional profiling of human tumor cells measures the actual response of tumor cells to drug exposure. Following this exposure, they measure both metabolic (cell metabolism) and cell morphology (structure). The integrated effect of the drugs on the whole cell, resulting in a cellular response to the drug, measuring the interaction of the entire genome.

No matter which genes or proteins are being affected, functional profiling is measuring them through the surrogate of measuring if the cell is alive or dead. It can measure the net effect of everything which goes on in the entire genome of a cancer cell. It can look at both the anti-tumor and anti-microvasular effects of cancer drugs. Are the cells ultimately killed, or aren't they?

Identifying molecular predisposing mechanisms still does not guarantee that a drug will be effective for an individual patient. Nor can they, for any patient or even large group of patients, discriminate the potential for clinical activity among different agents of the same class.

What is needed is to measure the net effect of all processes within the cancer, acting with and against each other in real time, and test living cells actually exposed to drugs and drug combinations of interest. The key to understanding the genome is understanding how cells work.

Reference:
Functional profiling with cell culture-based assays for kinase and anti-angiogenic agents Eur J Clin Invest 37 (suppl. 1):60, 2007
Functional Profiling of Human Tumors in Primary Culture: A Platform for Drug Discovery and Therapy Selection (AACR: Apr 2008-AB-1546)

Hi,
I hope you remember me.....
It seems that the things are getting more and more bad.... :-(
I had mailed before you 2-3 months ..
I wanted to know have visited the Dr.Yeshin Dhonden? or not?
if yes then are you still continuing his treatments or not?

Have faith in your love..

God bless you....
Sunil

I am so sorry for troubling you but I wish to know your experience.. it will be very helpful when I suggest someone about Tibetian medicine...

I am not the Strong Follower "Swim against the Flow attitude" but I do believe that when conventional methods offer no hope then why not follow something that offers ray of hope...

Also I was quite worried since there was no update, no reply from you...

take care
Sunil

Hi Sunil,
We did get to India but could not get to see Dr. Donhden. I must admit your country is full of mystical ideas and people. I have not been on the site much after India. I agree our eyes were opened to the powers of the universe and we practice what we learned daily. We went to Ahmedabad were we met with a Vantu doctor and grand master, Dr. Amaresh Mehta. He is also highly regarded in the scientific world in regards to geopetic stress. He feels this is the main source of all cancers. Once we returned to Greece about 3 weeks later we brought him to Greece to correct our house. Of course this will take about 3 to 4 months and hopefully by the end of December the house will be free of geopetic stress. We are also doing Auverdya medicines, meditation and all of this has helped give us strength and hope.

We are also now devout vegetarians as recommended by all people in India. In general we feel much better.

We do not give up hope - we have a saying in Greek "hope dies last" .

Thank you for insisting on going to India. If there is anything that has made us whole and calm is the teachings of your country.

God bless

Barbara

Hi Barbie,
Oh.. it was realy miss-fortune that you could not get to see Dr.Yeshin Dhonden.. May be you should have confirmed his availibility before coming......

I would like to tell you something about all those "Mysterious Ideas and People"......

Yes, in India there are lot of mysteric things which are beyond the explaination for science atleast right now.... like
Vastu-Shastra (it is not Vantu...Science of Geopetic force as you said),
Black-magic (like Voodoo magic in Africa),
Palmistry (telling fortune by reading lines on surface of Palm),
Astrologist (telling fortune from Birthchart which shows position of various planets at the time of birth),
Gemologist- who say by waring specific type of stone like diamond, emreld, saffire etc your problems may get solved..
Rudraksha.. A lord Shivas symbol... their are lot types each with differnt purpose.. and cost varies from few dollars to thousands ..
Worshipers of Demi-Gods,
Saints or Yogis, who claim to possess some sixth-sense or spiritual powers etc...whose blessings can cure many problems..

I personally feel they all definitly have some sense and you will always find people claiming to be benifited from these things..

But now l want to show you the dark side of it.....

The proponents of each method claims that your problems are due to Something going wrong in what they profess..
For example.. A Vastu-shastra advocate will say that your problems are due to Incorrect Vastu and correcting those doshas(errors) in Vastu wil solve your problem...(like Dr. Amaresh Mehta)
An Astrologist will prepare your Birth-chart of planet positions and say your problems are due to effects of some planets and suggest remedies for that ...
A black-magician may feel that some evil powers are behind all these things..
and so on.....

But you need to understand that at a time not one but many such mystic forces can be at work and you need to do something for each to get really benifited....
but again you can never know which once are.....

Also each of the above has some limitation.... for example an incorrect Vastu-dosha may cause such problems like Failure in life, business, diseases etc but again simply correcting the Vastu may not revert back the serious disease...

But in general I would say looking at Vastu-shastra and Astrology would bea goo start..
(in addition whatever efforts you are doing for medical treatments..like ayurveda, alopathy, dieting etc)
You can also take help from Saint... not necessarily a Hindu, Indian but any pure Saint from any religion like Christine, Muslims etc...
How to identify one? You feel a strong Aura, a sense of confidence, mental peace when you meet one who is truly devoted and connected to God..


But now the problem is, not all those who claim to be the Masters are real masters.....
Infact I will say 99.99% are fake and do all these things to make MONEY...
It does not take much efforts to read some books and give impressing speech to some one like say You who might not have ever heard of these things..
(infact I also do know something about Vastu-shastra, know some experts )
Here you will find thousand of people claiming to be experts of Vastu or expert of palmistry or expert of Astrology or having mysterious powers etc fooling millions (yah.....we have that much popoluation to get fooled)
So you should be very very very careful otherwise you may end up wasting lot of money and may cause some harm too...if choose to rely on them completly....
Here poeple have lost their life, money, fortune running behind these magical cures....
So I felt I must warn you...

General rule is, those who are real experts of these mystical things, they have invested their life in learning it or acquiring knowledge or supernatural powers..
for them money is the least important thing in life....
So those who ask for "Extra-ordinary" amount of money or are ready to help only in exchange of money are most likely fakes....

Dalai Lama and those Buddhist monks, they can actualy control rain with their power of Mantras...
and they never care for money..
You see Dr.Dhonden, he gives medicines for very very nominal fees..

So those who are realy good at these things, usualy they do it for social cause and belive in using their knowledge , power for benifit of society and not to make money...
yah they may make living out of it but it is simple living and aim is not be Rich using these skills or powers
(infact such powers gets lost if the practioner mis-uses them)

Somethings that I can do for you if you wish (ofcource just as inspire.com buddy and surely not for even a single penny):
1. Please tell me what corrections Dr. Amaresh Mehta suggsted in your house?
I have a friends who can check out that ...
You will have send the diagram, photos of your house with directions marked to get in-depth analysis

2. I also happen to know an Astrologist
(not a friend, I know him through my frinds mother, I will be visitng him may on this week end for my personal work
he is 75 year old guy practising Astrology since last so many years and not a Money freak),
let see what he suggests..
For that I will need your husbands Date of Birth, Time of Birth and place of birth including name of town, city, state, country, day-light correction if any etc...
Or a Birth-chart if you have prepared it ..

God bless you both...
take care
Sunil

This post is directed Sunil (fight Cancer) and Barbara (bariegabriel). First I would like to thank you both for shedding some light on these alternative practices. Sunil, I totally agree with you that these type of things should be used in caution and that anyone seeking to make large amounts of profit off of peoples hardships, is only seeking to line his own pockets.

I am very concerned about this Dr. Amaresh Mehta who both of you discuss, because i understand that he will be giving a semenar in Greece again and people i know are considering having him to their homes to correct their homes as Barbara mentions.

Barbara, can you please tell us how much he charged you to preform this correction on your home and why did he say that it would take four months to feel the affects. Also, can you tell us how your husbands health is now and overall status of your family life has improved since the Doctors visit to your home.

I am very cautious and concerned about calling on these type of Spiruatual healers, because they invoke false idols or false Gods and call on the supernatural side of things such as numerology and forutnue telling and reincarnation. Orthodox Christians believe that we only have one God and we are waiting for the life afterlife. Our religion does not have reincaration. My worry with all this is that by seeking out these type of sources for healing that we may bring upon other evils.

This brings me to Sunils response and warning to you when he speaks about false or fake Masters from India who claim that they can form mircles (which by the way, I believe that only strong faith in God can produce mircles). When sunil says you should be very very careful because not only can you waste your time and lots of money but also bring on personal harm to yourself, your family and your home.

I thank you Sunil for these words of caution and i agree that for one to feel peace and overall good health (mind and body) is to meet a charismatic who is truely devoted to God and does not seek monetary compensation for his work.

Sunil can you please give us some advice about Dr. Mehta because i want to advise the people who i know are considering paying him a large fee to come and correct their homes. I am truely worried about this, so any information advice that you can give would be a big help. I have been to Indian and I have friends there, but I have not heard of any thing about this man and I truely am concerned about the dark side as you mention.

May God Bless you and your family for sharing this important information with us, when people have been problems they turn to drastic measures but sometimes these measures can bring further hardships.

Barbara I will keep you and your husband in my prayers.

I look forward to hearing from both of you.

God Bless you all

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