Hello all. I'm new to this forum. Was looking for some input. My father was diagnosed with Anaplastic Astrocytoma in April of this year. He had a craniotomy removing about 95 percent of the tumor and then the 6 weeks of radiation and temodar. All went well. He developed fevers for weeks the end of Aug. No positive text results. Had his first maintenance cycle last month. Did ok. In between all of this he needed a shunt due to hydrocephalus. The other night he had taken his first temodar of the second cycle. I think he had a reaction--fever, chills, redness in face and itchy. Tonight he is taking a lesser dose to see if he had a reaction again. If so then Oncologist says Avastin is next step. I was wondering what side effects people have experienced. Is it painful? Does it knock you down? All questions he is asking! Any help would be appreciated!