I don't come on here much, but I do read occasionally. I have been diagnosed with gastroparesis and maybe IBS-C (not officially diagnosed, but GI says maybe). Either way, constipation was a big problem for me, like for many of you. I was taking a LOT of Miralax and going every 5+ days, with a lot of bloating and pain. I know that's not as bad as some of you here, but still not pleasant.
My GI put me on Linzess (290 mcg). I have been taking it for about 3 weeks now. I also take 1 dose of Miralax in the evenings (just one!). So far, I have a BM almost every morning after I drink some water and eat a little something! It is always loose and watery, and usually VERY urgent - I would say I have 3-6x watery episodes over the course of an hour or two. Unfortunately, this means it's nearly impossible to leave the house in the morning. I'm not sure if this means I need a lower dose of the Linzess or maybe less Miralax - when I cut back on the Miralax I don't seem to go as much. I am going to experiment a little and see what happens, but I'm afraid to change too much since I am actually going. And because I'm taking way less Miralax than I used to, I have a lot fewer "unpleasant" feelings (cramping, bloating, etc. - that is still there but not as bad!).
I haven't had any other side effects from the Linzess. Other than the watery diarrhea, it has worked pretty well for me. I am always a little wary of taking a new drug, but I thought I would share a positive experience for those interested in taking this drug. I've also found that being able to go to the bathroom every day does seem to help my nausea (a little). My nausea seemed to get worse after not being able to go for several days.
Anyway, hope this helps! For reference purposes, the other drugs I take for my stomach issues are omeprazole 20mg (Prilosec), domperidone, and Zofran as needed.
Thanks all! I don't read much on this site because it tends to make me really depressed about my condition.