Gastroparesis & Autoimmune Connection

I am new to this site and was wondering if anyone has any information on the connection of GP and autoimmune diseases. I have various markers which lead toward an autoimmune disease and was Dx. with GP about 9 years ago. I am progressively getting more symptoms and I go from Dr. to Dr. trying to find answers. Not to mention the Poly-pharmacy I have going on here. At this time, no one is willing to give my autoimmune disease a name. One doctor referred to it as a "zebra" so, that is what it is - - - we treat the symptoms but, never get down to the root cause and determine if it is fixable or not. I am set for another endoscopy Monday. Thoughts???

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Interesting. When I was diagnosed with GP 3 years ago, the first thing my gastroenterologist did was try to find the cause, and he sent me right to the rheumotologist. She did bloodwork, and found that I have a positive ANA, indicating some kind of auto-immune disease. (I do have Hashimoto's Thyroiditis). A few markers were positive (sjogren's syndrome, scleroderma, and a few others). However, I didn't (and still don't) have any symptoms of these diseases. My gastroenterologist also said to me a few times that it looks like I have a lupus-like profile -- but I don't actually have lupus. Maybe it's developing? He is looking for an answer for the GP in autoimmune diseases.

Now he wants me to go back to the rheumotologist again... but I don't really want to hear about all these diseases that I might have, or might develop, but I don't currently have symptoms for. Seems useless.

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I too have what they have titled an "autoimmune-like disorder" they won't give it a name, keep saying it will probably develop into a recognizable disorder in the future. For now, they don't really do anything for it, because they are afraid of making things worse. Go figure.

Have a history of autoimmune in my family, my mother had Guillen-barre syndrome when she was 18.

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My ANA has been positive (a few months ago it was 1:160), which might mean an auto immune disorder is developing.

Beyond GP and CIP I also have diffuse hairloss (chronic telogen effluvium) and a subfebrile body temperature + the parietal cells in my stomach were tested positive.

My doctor told me I might develop more disorders in future, which will make it easier to confirm the diagnose of an auto immune disease. No thank you!

When I was 14 years old, I suddenly started to suffer from idiopatic nodular panniculitis. It was a rare condition that suddenly disappeared after 9 years, without any visible scarring.

Further, my internal map is a bit of a mess. I have two left lungs instead of a left and a right one, I have multiple spleens, my stomach is situatied right near the back of my body, and so on ....

Anyway, I do believe I have an auto immune disorder. In the past I had 6 missed abortions. This must have something to do with it, I think.

Regards, Lice

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Thanks for sharing, Everyone! I too have a +ANA and am now starting with new symptoms. I have been to an immunologist, hematologist, etc. and no real results except for a new med here and there to treat the symptoms. They attempted twice to give me iron transfusions and I went into anaphalactsis both times now no one wants to try. I was told my next step is a blood transfusion - have any of you had to have that??I am praying I don't have to go that route. I am very sensitive and am afraid of anaphalactsis- that is a little too close to death for me. Do any of you recommend an aggressive GP/autoimmune specialist? My local physicians keep referring me out. I have been to Pittsburgh, Hopkins, etc.

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I always thought the person to see for autoimmune things was a Rheumotologist. Although, I do see my Endocrinologist for the Thyroiditis because it affects the endocrine system. I never heard of an autoimmune specialist, but if there is one I would say to let him/her check you out. Since you are having new symptoms, maybe they might know what it is.

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I too have rheumatoid arthritis which is an immune disorder and have had various allergies throughout my life. The RA was diagnosed 7 years ago, the GP last week but I think the RA has been there for the last 30 years. I lived a very stress filled life for many years that opens us up for immune disorders to take over. Not enough answers in medicine yet it looks like.

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Hi,
I was just getting ready to get off due to fatigue, but needed to say that there is definitely a connection. I have every one known to man practically. The GI problems are the start of a lot of it. I have so much info in my head I mustn't start or I'll be sorry - I'll never get off. I promise to write later. I have GP, Systemic Sclerosis, IC, MS, and many many other diseases.
Blessings, Jan

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Thanks for responding I would love to know more about the autoimmune connection with the GP. Wishing you the best!!!

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Besides having thyroiditis in 2002, I was diagnosed with autoimmune autonomic neuropathy. My old rheumatologist also kept a close eye on me thinking that I would develop another autoimmune disease, as one often leads to another. I was on IVIG for the neuropathy but had to stop it due to a severe reaction. I also have autoimmune urticaria and raynaud's phenomenon. I was recently diagnosed with Chilbain's disease which is also autoimmune. The GP and colonic inertia are thought to be the result of the neuropathy. It still does not explain my multiple anaphylactic shocks, asthma, eosinophilic enteritis, and all of the other allergic things I have.

Mimi

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This may be the most interesting, yet frustrating, part of having CIP, RA, uveitis and a host of lesser autoimmune disorders. While all my docs, all of them expert specialists, acknowledge that these links occur, it appears that there is little or no exploratory or investigative reserch or treatment options to show for it. As my GI doctor puts it, "there's no magic bullet." I'm not asking for that, but I sure would like to think that, with all the genetic marker research emerging, we could all receive focused attention. Another common reaction from my doctors is that, even if there are links between CIP, RA, MS, lupus, etc., it won't change the treatment options for any of these. After living with all this since 1974, I'd like to think there's hope that my kids and grandkids WILL have better treatment options in the future.

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