Does Domperidone have side effects like Reglan???

Hello all,
My doc is putting me on Domperidone, but I am afraid because I've heard it's about as bad as Reglan, is this true? I didn't feel well on Reglan, and I'm afraid this is going to do the same. I'm also on amitripyline and they're about to put me on Zoloft too. Has anyone tried any or all of these drugs? Did they help/hurt you?

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The only side effect from Domperidone I ever had was headache. When I first started Reglan it made me drowsy, and I liked that since I have really bad insomnia. That only lasted for about three weeks though. Neither drug helped me at all.

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Domperidone and Reglan are both dopamine antagonists, but Domperidone is less likely to cause neurological side effects because it does not cross the blood-barrier as Reglan does. I know in my case, I took Reglan a few times, and I experienced extreme restlessness and uncomfortable anxiety such that I decided not to take it again. The only side effects I had on Domperidone, and this was mostly on the higher doses, was a small increase in breast size and slight lactation, but nothing too bothersome. Neither one helped me either, but I have heard from others whom they have helped. Each person reacts uniquely to each medication. I hope that you will react well to the Domperidone and that it will prove helpful to you along with the other medications. Best of wishes and many hugs.

Warm regards,
Bobbiejo

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I am on 20 mg 4x a day of Domperidone with the exception of dinner time when I take 30 mg. It has been a month and I havn't really noticed any side effects yet. If the only weight I can gain is in my breast then I won't have a problem with that!
In the morning I feel a lot better but still full and exhausted in the evening. I occasionally take Hyomax for spasms, Celebrex for "IBS" and Myralax in the evening.
Reglan made me extremely depressed and anxious and will never try that again.
I would give Domperidone a try and see what happens.
The doc I just saw in Seattle wants to try me on Erythromycin which sounds very unpleasant so I'm hoping Dom will work better with increased dose.
Sounds like we have a few things in common, let me know if you have any questions!

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I've been on Domperidone 20mg 4x/day for 3 years. I don't think it helps me out at all considering I have been hospitalized 12 times this year alone, for at least 6-10 days at a time. I hope you have better results. I know some people swear by it, so hopefully you will be one of those people. Good Luck

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Thanks for your responses everyone! Guess everyones different and we all have to try the whole list of meds!

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It can be used in patients with Parkinson's disease because, unlike metoclopramide domperidone does not cross the blood-brain barrier.Individual incidents of problems with the drug include cardiac arrest and arrhythmia, complications with other medications, as well as complications with improper intravenous use A recent paper suggests there may be increased risk of seizures to neonates of mothers taking oral domperidone

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it has helped my daugther 29 y to stay out of a hospital for a two week period. she has been admitted to hospital over 200 times in a year and half. she has the hardest case cleveland clinic has had. her stays avg. between 6- 20 admitts per month. this is the first drug that has made a change. what is it cost you for domperidone 10 mg we paid 78.00 usa for 10 pills.

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I have to go look in the PDR but yes it has side effects. It's not as mental for me as Reglan (which I think should be pulled from the shelves).

It does have extensive side-effects which I have to go look up because of the long list.

I have too many other problems and it made my heart tachy - 140; plus my blood pressure went down when I stopped taking it. I also had terrible muscle cramping.

I don't know what to do now. We are into fruit smoothies.

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I would suggest to everyone using Domperidone to get it from In House Pharmacy near New Zealand. They have the best price that I have found, by far. My GI doctor told me to use them. I get 600 pills (10 mg) for $77.00. (That's with a $3.00 discount for being a repeat customer - so first time customers will pay $80). You can get more pills, or less, at one time. You don't need a prescription. And I don't think they charged me for shipping. Their web site is inhousepharmacy.com. Phone # 1-877-271-6591. Call around 6pm Eastern time to reach someone there. If you get a machine, leave your name / number and they will call you back. They have great customer service.

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ablevac~ I recieved my pills from candrug.com I got 720 pills for 118.00 where did you get yours? Sounds expensive.

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GpGirl5~ Thanks for the tip, might use them next time, although candrug is pretty good too, and has great customer service as well. I'm getting some more medications from them as well, soooo much cheaper than going thru the U.S. for medicines..

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I have been using Domperidone for 5 years now. Have not had any side effects and I take it 3 times a day sometimes 4 if nausea is real bad before bed. Just make sure you take it at least 20 min before eating. Reglan was a NIGHTMARE. Reglan gave me severe tremors and put me in a depressed state. I use CanadaDrugs.com for the Domperidone. They were the cheapest around and very reputable to deal with. Never had any problems with my orders.

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shamrockmom~ thanks for your response. I used the same pharmacy for my domperidone. I have been on it for two days now and I'm getting pretty bad stomach cramping, hopefully it will go away after a while. I'm happy to hear you responed to the medication well :) Hopefully I will too

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Carebear169:

My wife has had severe gastroparesis for about 17 weeks as a result of pancreatic cancer surgery (Whipple). Her primary doc's were pretty clueless as to what to do. We went to Georgetown Univ Hospital, and they recommended trying domperidone and referred us to Canada Drugs Online also. They pills arrived and she has been taking it for three days. It has stopped the nausea and appears to be working. BUT, she has also had severe stomach cramping at night (only at night).

By the date of your posting, it would seem you are a few days ahead of us in this course. We are wondering if the cramping clears up any with time? Have you adjusted the dosage? Or have you discontinued any other medications?

We hate to stop taking it, since is the only med that actually works.

Good luck in your treatment.

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evans22182~ Yes, I am a few days ahead, well lets see my 3rd day into Domperidone was the hottest day of the year (and I just moved somewhere where they don't have AC), it was over 100, and I went to the hospital because of servere stomach cramping (think from Doomperidone) and Dehydration. I get my stomach cramping all throughout the day. I have called my doctor, but he has not returned my phone call as of yet. He told me to take 20mg 4 times a day, and I knew it was too much for me so I took it 2-3 times a day, and yesterday for the first time I took it 4 times. I am still getting muscle cramping, but it's not as severe it seems, but it's not taking away any nausea, or the feeling of fullness, but I know it could take some time to work. I have not discontinued any medications at this time, I'm just going to take everything for now and see what happens :) Let me know how your wife is doing?? And also, if she finds any tips! Thanks :)

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Is domperidone available in the US at this time?
I currently take Raglan and it gives me real problems with fatigue, depression and anxiety.

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LUBECKTECH~ It isn't available in the U.S., but you can find a doctor (gastroenerlogist) that can prescibe it to you, then you go to www.candrug.com and order your medication. I have been to 2 other doctors that told me I couldn't get it in the U.S. but it's not true, you need to go to a motility specialist to usually get the medication. Doctors I guess don't know it, but if they enroll in a special program they can prescibe it to you, I found my doctor on www.digestivedistress.com and I'm so glad I went to it because I would not have gotten the medication. Reglan is NOT a good medicine, you should get off of it right away! Reglan needs to be pulled from the shelves! Domperidone is not dangerous like Reglan is, doesn't cause Parkinsins like Reglan does, also through Canada Drug, ALL medications are cheaper, my Domperidone was $133, they gave me over 700 pills, which lasts 3 months. I have been starting to recieve ALL my medications from Canada Drug, because it's at least 3 times cheaper than the U.S. espically if you don't have insurance! I highly recommend them! They can also answer any questions you may have, the lady I have been speaking to is wonderful! I hope this helped some! Let me know if you need any more info! :) Oh yes, their phone # is (888) 488-3784

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I am going on 2 years of having the movement disorder myoclonus due to Domperidone. I am proof that it crosses the blood brain barrier. My neurologist at the Ohio Cleveland Clinic confirmed this. My gastroenterologist suggested I take the drug for my slow motility in stomach, I took it for one year. If you saw me move you would think twice of taking this medication. It is not easy to live with a movement disorder. My children have watched me move everyday for almost 2 years. It is depressing to have this disorder. Please do not believe that it does not cross the blood brain barrier nor that it is better than Reglan. My doctor told me to get my medication from an online pharmacy in Canada. I have nothing but regret from taking this medication. I hope this post saves others form developing a movement disorder.

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I'm on Domperidone for SIBO and have been for 3-4 months. My compounding pharmacist had such concern about putting me on a drug that used to be used to induce lactation that he wouldn't dispense it,
so I did quite a bit of research on it since he was so cautious.

My own research turned up nothing negative on it, except that it can induce lactation and BTW, there is someone on this website who is reluctantly lactating because of it.

I had my gynocologist research it because I've been on HRT for years and was concerned that it would multiply what I'm already taking, but she said it was okay after checking it out.

There are some contraindications and I think antidepressants is one of them, so you need to look into that.

I was very surprised that it had the clean report that it did. I felt sure my GI doc had prescribed something I would not want to take, but I'm taking it and tend to manage my condition a little better when I do.

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Just wanted to let you know about this web site where you can get Motilium which is the same thing for a lot less money. I can get 6 month supply 3 pills daily for around $78.00.
www.inhousedrugstore.com
Hope this helps my gastrologist told me about this web site his wife gets her Motilium from there also.
Faye / aka rejection

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