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OK gang i have a really dumb question.. what is triple negative? I am hr/pr positive, but her2 negative. I also do NOT have the bc gene. what am i? duh
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TRIPLE NEGATIVE
- By lusianagal
- Posted July 23, 2009 at 1:21 pm · 3 replies
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- By chainsawz
- Posted July 23, 2009 at 1:27 pm
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That is not a dumb question - I really didn't understand until recently :> Triple negative is ER negative, PR negative and HER2 negative.
Here's a better explanation from the Triple Negative Breast Cancer Foundation: http://www.tnbcfoundation.org/index.html
These subtypes of breast cancer are generally diagnosed based upon the presence, or lack of, three "receptors" known to fuel most breast cancers: estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2). The most successful treatments for breast cancer target these receptors.
Unfortunately, none of these receptors are found in women with triple negative breast cancer. In other words, a triple negative breast cancer diagnosis means that the offending tumor is estrogen receptor-negative, progesterone receptor-negative and HER2-negative, thus giving rise to the name "triple negative breast cancer." On a positive note, this type of breast cancer is typically responsive to chemotherapy. Because of its triple negative status, however, triple negative tumors generally do not respond to receptor targeted treatments. Depending on the stage of its diagnosis, triple negative breast cancer can be particularly aggressive, and more likely to recur than other subtypes of breast cancer.
- By lusianagal
- Posted July 23, 2009 at 1:31 pm
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thank you !! thats why when i was first dx in 99 they told me if i had to have bc this was the one to have because you CAN control the estrogen and progesterone in a person. now it makes sense! thank you!
- By sr2603
- Posted July 24, 2009 at 8:43 am
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Chainswa gave a great description of triple negative luisan. I am triple negative with mets to both lungs for 18 months. Still doing well, apart from the usual chemo side effects. Aparently the good thing is this nasty cancer responds very well to chemo. There is also a new thing on the horizon called PARP I think - it apparently is having some amazing results. My oncologist is going to try and get me on some kind of trial with it if the current chemo fails. I am thinking positive though and expect the treatment to work.
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