scared of Doxil

I will be 90 in a few months, DX in 2004 er + h- two years on tamoxofin, then bumps in same breast, met to chest wall, 5 yrs on femara, bumps cleared, fine till other bumps, rediation for 33 treatments,switched to Faslodex, twice a month, after 7or 8 minths count started going up (last year) switched to Xeloda for a few months but count kept going up, so have been advised to start Doxil. I have hesitated for a month. Side effects scare me. I am concerned about quality of life at this point, and wondering how this will affect me.

Second riddle...I just learned extensive mets to bone...Zometa recommended. I took it once several years ago (bone density showed osteopenia hips) but didn't continue because I had flu-like symptoms for several hours one day later: 102 fever, pain in muscles, trauma sites. It is supposed to be the best and I wonder if the befefit will far outweigh the monthly discomfort.

Any experience, observation, advice gratefully received.

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Buttonbx - god bless you 90 years old! I have no advice regarding Doxil, but I hear that the SE's from Xgeva are much easier than Zometa. Currently I am on Femara and Xgeva and have no side effects from Xgeva, my side effects are from Femara (hips and knees feels like I have Arthritis). You should ask your doc about Xgeva. I hope this is helpful.

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And I thought I was the oldest Inspirette, way to go buttonbx. (I'm only 76.)

I had no side effects from either Zometa or Doxil. Unfortuanately Doxil didn't work on my many tumors.

Good luck to you,
Jan

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God bless you 90 years old and still going strong.Just want to wish you Good Luck and will keep you in my prayers!!!!

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Thank you all very much. I hope there will be more answers.

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Forom your meds, it sounds as if you are Er=. Whar about Aremidex or Aromasin. Both hormaonal agents. I have been taking Aredia for bones for 51/2 years and seem to have no real side effects. Best to you.

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Biphosphonates in general can cause bone aches and flu symptoms. Xgeva is supposed to be much better, as far as side effects. Claritan taken just after the infused Zometa/Xgeva, is great for decreasing those side effects (sold over the counter). Doxil is a lipid-bound Adriamycin. It has less side effects than Adriamycin. I hope that the doxil gets rid of your BC.
Best regards.
Anita

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I will echo the suggestion to try Xgeva - just a shot in the arm once a month and does (for many) have fewer side effects. I have done both that and Zometa and had a MUCH easier time on Xgeva.
Re Doxil, I understand where you are coming from. Have you talked with your onc about other options like Halaven etc.? I would think that something that has the ability to adjust dose easily might be better side effects... don't know enough to really say tho.
I have heard from many over the years that more frequent, but lower dose, regimens are easier to tolerate and can be as effective.
Whatever you decide, I wish you the best. Don't be afraid to try the Xgeva. I have very widespread and painful bone mets and have found both Zometa and Xgeva to be helpful and worth the temp side effects.

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Thank you so much, nice people...I guess this question of mine will remain open (I am new here,)

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