I have just been put on the cocktail above for my supra-clavicle lymph node involvement. My doctor was doing this on a 21 day cycle with Ixempra and Avastin on day one and Xeloda starting day 1 through day 14. After my infusion on Friday I was ok until Sunday when I went down for the count pretty much 21 hours a day for 5 days. This was way more difficult on my body than TAC. I stopped taking the Xeloda last Friday but my doctor wants me to start it up again this Friday. He said is it not the Xeloda it is the Ixempra that gave me the total exhaustion. He wants to give me the cocktail on a weekly basis next round with Ixempra weekly, Avastin day one and Xeloda on 7 and off 7. Anyone ever done this cocktail this way and how did you handle it. I was not prepared for the evilness of it all this first round. Thanks in advance!