Initially, the tumor marker for my breast to bone cancer was CA27,29. Tamoxifen then anastrazole caused the CA27,29 to decrease from 250 to the 30's, where it plateaued. CEA started to rise, doubling every month for several months to a high of 1400 or so. My oncologist felt I was working on a second primary, but colo/endo didn't produce any concerns. Had lab this week and both the CA27,29 and CEA are on the rise...both up about 30 since last month. My oncologist said it was odd that the tumor marker went from CA27,29 to CEA when that happened and he's perplexed again that both are now on the rise. Has anyone here had that happen and what was the outcome?