Multiple system atrophy (MSA) is the current name for disorders once known individually as striatonigral degeneration, sporadic olivopontocerebellar atrophy, and the Shy-Drager syndrome. MSA is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure (such as lightheadedness or fainting spells, constipation, erectile failure in men, and urinary retention) combined with tremor and rigidity, slurred speech, or loss of muscle coordination. MSA affects both men and women, primarily in their 50s. It can progress swiftly or slowly, but people with MSA generally survive for 9 years after the appearance of symptoms. There is no remission from the disease.
Sources
National Institute of Neurological Disorders and Stroke
