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Pyelonephritis is a kidney infection, usually from bacteria that have spread from the bladder. Severe or recurrent infections may cause permanent kidney damage and lead to chronic kidney disease.
In rare cases, infection in the kidney may spread to the bloodstream. Infection of the bloodstream is a serious condition called sepsis. Acute renal failure, a temporary condition in which the kidneys stop working, can also result.
Sources
National Institute of Kidney and Urologic Diseases Information Clearinghouse